Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hey1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HEY1
- Mouse genes Hey1
- Rat genes Hey1
- Zfish genes hey1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hey1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HEY1	IDA		Human	PMID:15485867
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	HEY1	IDA		Human	PMID:21290414
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Hey1	IDA		Mouse	MGI:MGI:5285133\|PMID:21290414
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hey1	IDA		Mouse	MGI:MGI:5285519\|PMID:21259317
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hey1	IDA		Mouse	MGI:MGI:3603871\|PMID:16199874
Molecular Function	GO:0042802	identical protein binding	Hey1	IPI	PR:Q9WV93	Mouse	PMID:11076679
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:P43694	Human	PMID:15485867
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:Q9NQ87	Human	PMID:21454491
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:O75593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:Q15038	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:Q8NEK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:Q96CS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:Q99697-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY1	IPI	UniProtKB:Q9BYJ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Hey1	IPI	UniProtKB:Q62440\|UniProtKB:Q9DBX7	Mouse	MGI:MGI:5285519\|PMID:21259317
Molecular Function	GO:0005515	protein binding	Hey1	IPI	UniProtKB:P43694\|UniProtKB:Q92908	Mouse	MGI:MGI:3603871\|PMID:16199874
Molecular Function	GO:0005515	protein binding	Hey1	IPI	UniProtKB:Q9DA73	Mouse	MGI:MGI:3809308\|PMID:14648848
Molecular Function	GO:0005515	protein binding	Hey1	IPI	UniProtKB:Q15327	Mouse	MGI:MGI:5294529\|PMID:20599664
Molecular Function	GO:0005515	protein binding	Hey1	IPI	PR:Q60722	Mouse	PMID:11076679
Molecular Function	GO:0005515	protein binding	Hey1	IPI	PR:P15806	Mouse	PMID:11076679
Molecular Function	GO:0005515	protein binding	Hey1	IPI	PR:P20067	Mouse	PMID:20231428
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HEY1	IPI	UniProtKB:P27540	Human	PMID:10692439
Molecular Function	GO:0043565	sequence-specific DNA binding	Hey1	IDA		Mouse	PMID:22615585
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HEY1	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Hey1	IDA		Mouse	MGI:MGI:5285133\|PMID:21290414
Cellular Component	GO:0005634	nucleus	Hey1	IDA		Mouse	MGI:MGI:5285133\|PMID:21290414
Cellular Component	GO:0005634	nucleus	Hey1	IDA		Mouse	PMID:11486044
Cellular Component	GO:0005634	nucleus	Hey1	IDA		Rat	PMID:11741889\|RGD:70528
Biological Process	GO:0001525	angiogenesis	HEY1	IEP		Human	PMID:11866539
Biological Process	GO:0009948	anterior/posterior axis specification	Hey1	IGI	MGI:MGI:1341884	Mouse	PMID:15680351
Biological Process	GO:0003180	aortic valve morphogenesis	Hey1	IDA		Mouse	MGI:MGI:6158746\|PMID:22110751
Biological Process	GO:0060842	arterial endothelial cell differentiation	Hey1	IGI	UniProtKB:Q9QUS4	Mouse	MGI:MGI:3040159\|PMID:15107403
Biological Process	GO:0060840	artery development	Hey1	IGI	MGI:MGI:1341884	Mouse	PMID:15680351
Biological Process	GO:0003190	atrioventricular valve formation	Hey1	IMP		Mouse	MGI:MGI:3703467\|PMID:17259303
Biological Process	GO:0003181	atrioventricular valve morphogenesis	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0001568	blood vessel development	Hey1	IGI	MGI:MGI:1341884	Mouse	PMID:15680351
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	Hey1	IGI	MGI:MGI:1341884	Mouse	PMID:15107403
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0060411	cardiac septum morphogenesis	Hey1	IMP		Mouse	MGI:MGI:3703467\|PMID:17259303
Biological Process	GO:0003208	cardiac ventricle morphogenesis	Hey1	IMP		Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0001708	cell fate specification	hey1	IMP	ZFIN:ZDB-GENO-190218-6	Zfish	PMID:27027936
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Hey1	IEP		Rat	PMID:20666749\|RGD:5132633
Biological Process	GO:0072049	comma-shaped body morphogenesis	Hey1	IEP		Mouse	MGI:MGI:3576186\|PMID:15821257
Biological Process	GO:0035912	dorsal aorta morphogenesis	Hey1	IGI	UniProtKB:Q9QUS4	Mouse	MGI:MGI:3040159\|PMID:15107403
Biological Process	GO:0003203	endocardial cushion morphogenesis	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	Hey1	IGI	MGI:MGI:1341884	Mouse	PMID:15680351
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	Hey1	IGI	MGI:MGI:1860511	Mouse	PMID:17303760
Biological Process	GO:0090162	establishment of epithelial cell polarity	Hey1	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0090162	establishment of epithelial cell polarity	Hey1	IGI	MGI:MGI:104876	Mouse	PMID:21300049
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Hey1	IGI	MGI:MGI:104876	Mouse	PMID:21300049
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Hey1	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Hey1	IGI	UniProtKB:Q9QUS4	Mouse	MGI:MGI:3040159\|PMID:15107403
Biological Process	GO:0014031	mesenchymal cell development	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0070168	negative regulation of biomineral tissue development	Hey1	IDA		Mouse	MGI:MGI:6158746\|PMID:22110751
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HEY1	IDA		Human	PMID:15485867
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hey1	IMP		Mouse	MGI:MGI:3603871\|PMID:16199874
Biological Process	GO:0010629	negative regulation of gene expression	Hey1	IDA		Mouse	MGI:MGI:3604167\|PMID:16025100
Biological Process	GO:0010629	negative regulation of gene expression	Hey1	IMP		Mouse	PMID:22615585
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hey1	IMP		Mouse	MGI:MGI:4365702\|PMID:19631204
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	HEY1	IDA		Human	PMID:18239137
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY1	IMP		Human	PMID:11486045
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY1	IDA		Human	PMID:16043483
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY1	IDA		Human	PMID:21290414
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey1	IDA		Mouse	MGI:MGI:6158746\|PMID:22110751
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey1	IMP		Mouse	MGI:MGI:3703467\|PMID:17259303
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey1	IDA		Mouse	MGI:MGI:3604167\|PMID:16025100
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey1	IDA		Mouse	MGI:MGI:5285133\|PMID:21290414
Biological Process	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	HEY1	IDA		Human	PMID:18239137
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	HEY1	IDA		Human	PMID:18239137
Biological Process	GO:0061314	Notch signaling involved in heart development	Hey1	IMP		Mouse	MGI:MGI:3703467\|PMID:17259303
Biological Process	GO:0007219	Notch signaling pathway	HEY1	IDA		Human	PMID:10964718
Biological Process	GO:0007219	Notch signaling pathway	HEY1	IDA		Human	PMID:25985737
Biological Process	GO:0007219	Notch signaling pathway	Hey1	IDA		Mouse	MGI:MGI:1889175\|PMID:10964718
Biological Process	GO:0007219	Notch signaling pathway	Hey1	IDA		Rat	PMID:11741889\|RGD:70528
Biological Process	GO:0002076	osteoblast development	Hey1	IGI	MGI:MGI:99829	Mouse	PMID:18986983
Biological Process	GO:0003151	outflow tract morphogenesis	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Hey1	IGI	MGI:MGI:99829	Mouse	PMID:18986983
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Hey1	IGI	MGI:MGI:1321394	Mouse	PMID:18986983
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hey1	IMP		Mouse	MGI:MGI:3040159\|PMID:15107403
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hey1	IDA		Mouse	MGI:MGI:6158746\|PMID:22110751
Biological Process	GO:0003184	pulmonary valve morphogenesis	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Hey1	IGI	MGI:MGI:104876	Mouse	PMID:21300049
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Hey1	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	Hey1	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	Hey1	IGI	MGI:MGI:104876	Mouse	PMID:21300049
Biological Process	GO:2001212	regulation of vasculogenesis	Hey1	IGI	UniProtKB:Q9QUS4	Mouse	MGI:MGI:3040159\|PMID:15107403
Biological Process	GO:0072087	renal vesicle development	Hey1	IEP		Mouse	MGI:MGI:3576186\|PMID:15821257
Biological Process	GO:0072050	S-shaped body morphogenesis	Hey1	IEP		Mouse	MGI:MGI:3576186\|PMID:15821257
Biological Process	GO:0036304	umbilical cord morphogenesis	Hey1	IGI	UniProtKB:Q9QUS4	Mouse	MGI:MGI:3040159\|PMID:15107403
Biological Process	GO:0060675	ureteric bud morphogenesis	Hey1	IEP		Mouse	MGI:MGI:3576186\|PMID:15821257
Biological Process	GO:0001570	vasculogenesis	Hey1	IGI	MGI:MGI:1341884	Mouse	PMID:15107403
Biological Process	GO:0060412	ventricular septum morphogenesis	Hey1	IGI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:3783952\|PMID:17303760
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	Hey1	IGI	MGI:MGI:1341884	Mouse	PMID:15680351

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.