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Hey1
Gene Detail
 Symbol
Name
ID
Hey1
hairy/enhancer-of-split related with YRPW motif 1
MGI:1341800
Synonyms bHLHb31, CHF2, Herp2, hesr-1, Hesr1, HRT1
Feature Type protein coding gene
Genetic Map
Chromosome 3
2.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:8663362-8667039 bp, - strand
From Ensembl annotation of GRCm38

  3678 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hey1

Human
homologs
Human Homolog HEY1, hes-related family bHLH transcription factor with YRPW motif 1
NCBI Gene ID 23462
neXtProt AC  NX_Q9Y5J3
Human Synonyms  BHLHb31, CHF2, HERP2, HESR1, hHRT1, HRT-1, OAF1
Human Chr (Location)  8q21; chr8:79764010-79767863 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygous null mice are healthy and fertile with no major developmental defects.
 
Interactions
Hey1 interacts with 184 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process anterior/posterior axis specification, arterial endothelial cell differentiation, ...
Component cytoplasm, nucleus
Function DNA binding, microsatellite binding, ...
External Resources: FuncBase
Expression
Literature Summary: (137 records)
Data Summary: Results (370)    Tissues (210)    Images (89)
Theiler Stages: 2, 3, 4, 5, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 332
Northern blot 19
RT-PCR 19
cDNA source data(116)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(126) cDNA(117) Primer pair(5) Other(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000040289 (Evidence)
Entrez Gene15213 (Evidence)
UniGene29581
DFCITC1573072
DoTSDT.111049940, DT.491795, DT.94187348
NIA Mouse Gene IndexU023816
Consensus CDS ProjectCCDS17232.1
International Mouse Knockout Project StatusHey1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040289 Ensembl Gene Model | MGI Sequence Detail 3678 C57BL/6J ±  kb
transcript ENSMUST00000042412 Ensembl | MGI Sequence Detail 2203 Not Applicable 
polypeptide ENSMUSP00000038014 Ensembl | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
InterPro IPR018352 Orange subgroup
Protein Ontology PR:000008528 hairy/enhancer-of-split related with YRPW motif protein 1
References (Earliest) J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
(Latest) J:204446 Tateya T, et al., Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea. Development. 2013 Sep;140(18):3848-57
All references(179)
Other
accession IDs
MGI:2139670, MGI:2139691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory