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Hey1
Gene Detail
Symbol

Name
ID
Hey1
hairy/enhancer-of-split related with YRPW motif 1
MGI:1341800
Synonyms
bHLHb31, CHF2, Herp2, hesr-1, Hesr1, HRT1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
2.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:8663359-8667256 bp, - strand
From VEGA annotation of GRCm38

  3898 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HEY1
Gene Tree: Hey1

Human
homologs
HEY1, hes-related family bHLH transcription factor with YRPW motif 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23462
neXtProt AC: NX_Q9Y5J3

Human Synonyms: BHLHb31, CHF2, HERP2, HESR1, hHRT1, HRT-1, OAF1

Human Chr (Location): 8q21; chr8:79764010-79767863 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygous null mice are healthy and fertile with no major developmental defects.
 
Interactions
Hey1 interacts with 184 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process anterior/posterior axis specification, arterial endothelial cell differentiation, ...
Component cytoplasm, nucleus
Function DNA binding, microsatellite binding, ...
External Resources: FuncBase
Expression
Literature Summary: (158 records)
Data Summary: Results (363)    Tissues (205)    Images (89)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 332
Northern blot 19
RT-PCR 12
cDNA source data(116)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA HEY1 ; Xenbase hey1 ; ZFIN hey1    NEW 
Molecular
reagents
All nucleic(126) cDNA(117) Primer pair(5) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000051396 (Evidence)
Ensembl Gene Model ENSMUSG00000040289 (Evidence)
Entrez Gene 15213 (Evidence)
UniGene 29581
DFCI TC1573072
DoTS DT.111049940, DT.491795, DT.94187348
NIA Mouse Gene Index U023816
Consensus CDS Project CCDS17232.1
International Mouse Phenotyping Consortium Status Hey1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051396 VEGA Gene Model | MGI Sequence Detail 3898 C57BL/6J ±  kb
transcript OTTMUST00000129939 VEGA | MGI Sequence Detail 2423 Not Applicable 
polypeptide OTTMUSP00000069732 VEGA | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
Protein Ontology PR:000008528 hairy/enhancer-of-split related with YRPW motif protein 1
References
(Earliest) J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
(Latest) J:220807 Shamis Y, et al., Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9
All references(199)
Other
accession IDs
MGI:2139670, MGI:2139691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory