Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HDAC6
  • Mouse genes Hdac6
  • Rat genes
  • Zfish genes hdac6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hdac6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043014	alpha-tubulin binding	HDAC6	IDA		Human	PMID:19228685
Molecular Function	GO:0043014	alpha-tubulin binding	Hdac6	IDA		Mouse	PMID:22174839
Molecular Function	GO:0008013	beta-catenin binding	HDAC6	IPI	UniProtKB:P35222	Human	PMID:18356165
Molecular Function	GO:0048487	beta-tubulin binding	Hdac6	IDA		Mouse	PMID:12606581
Molecular Function	GO:0070840	dynein complex binding	HDAC6	IDA		Human	PMID:14675537
Molecular Function	GO:0004407	histone deacetylase activity	HDAC6	IDA		Human	PMID:10220385
Molecular Function	GO:0004407	histone deacetylase activity	HDAC6	IMP		Human	PMID:23322205
Molecular Function	GO:0004407	histone deacetylase activity	Hdac6	IMP		Mouse	MGI:MGI:5605128|PMID:24882211
Molecular Function	GO:0004407	histone deacetylase activity	Hdac6	IDA		Mouse	PMID:11689694
Molecular Function	GO:0004407	histone deacetylase activity	Hdac6	IDA		Mouse	PMID:9891014
Molecular Function	GO:0042826	histone deacetylase binding	HDAC6	IPI	UniProtKB:Q8IXJ6	Human	PMID:12620231
Molecular Function	GO:0051879	Hsp90 protein binding	HDAC6	IDA		Human	PMID:15916966
Molecular Function	GO:0008017	microtubule binding	HDAC6	IDA		Human	PMID:19228685
Molecular Function	GO:0008017	microtubule binding	Hdac6	IDA		Mouse	MGI:MGI:4820954|PMID:19893491
Molecular Function	GO:0051787	misfolded protein binding	HDAC6	EXP		Human	PMID:17785525
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	HDAC6	IDA		Human	PMID:14675537
Molecular Function	GO:0030955	potassium ion binding	hdac6	IDA		Zfish	PMID:27454931
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q9HCU9	Human	PMID:16919237
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O14965	Human	PMID:17604723
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P35638	Human	PMID:17872950
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P35222	Human	PMID:18356165
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O15205	Human	PMID:19033385
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O60260	Human	PMID:19036992
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:A8MTZ0	Human	PMID:19081074
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q62623	Human	PMID:19167333
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q9NQC7	Human	PMID:19893491
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P00533	Human	PMID:20029029
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O94811	Human	PMID:20308065
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P04610	Human	PMID:21220424
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q14247	Human	PMID:21220424
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P03409	Human	PMID:21532619
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q14247	Human	PMID:21847094
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q60598	Human	PMID:21847094
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P17252	Human	PMID:21952047
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P21146	Human	PMID:22193721
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q9NQ11	Human	PMID:22645275
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O43490	Human	PMID:23084749
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O43490-2	Human	PMID:23084749
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P35222	Human	PMID:23084749
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O75923	Human	PMID:24687993
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q9Y4F9	Human	PMID:24687993
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:O15205	Human	PMID:25422469
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q9Y4F9-2	Human	PMID:27556504
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q99836	Human	PMID:29281743
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HDAC6	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	UniProtKB:D3ZEY0	Mouse	MGI:MGI:5818095|PMID:27737934
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	UniProtKB:P31750	Mouse	MGI:MGI:5616268|PMID:24955524
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	UniProtKB:Q99N13	Mouse	MGI:MGI:6368062|PMID:25873389
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	UniProtKB:Q80TQ2	Mouse	MGI:MGI:4820954|PMID:19893491
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	UniProtKB:P21146	Mouse	MGI:MGI:5314482|PMID:22193721
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	PR:Q9ESD7	Mouse	PMID:22174839
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	PR:P27612	Mouse	PMID:11689694
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	PR:Q01853	Mouse	PMID:11689694
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	PR:Q810I2	Mouse	PMID:22792322
Molecular Function	GO:0005515	protein binding	Hdac6	IPI	PR:O55131	Mouse	PMID:24113571
Molecular Function	GO:0033558	protein lysine deacetylase activity	HDAC6	IDA		Human	PMID:28516954
Molecular Function	GO:0033558	protein lysine deacetylase activity	hdac6	IDA		Zfish	PMID:27454933
Molecular Function	GO:0033558	protein lysine deacetylase activity	hdac6	IDA		Zfish	PMID:28516954
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HDAC6	IDA		Human	PMID:24413532
Molecular Function	GO:0048156	tau protein binding	HDAC6	IDA		Human	PMID:18636984
Molecular Function	GO:0048156	tau protein binding	Hdac6	IPI	UniProtKB:P10637	Mouse	MGI:MGI:6119868|PMID:19457097
Molecular Function	GO:0001222	transcription corepressor binding	HDAC6	IPI	UniProtKB:Q96JN0	Human	PMID:12535528
Molecular Function	GO:0042903	tubulin deacetylase activity	HDAC6	IDA		Human	PMID:12620231
Molecular Function	GO:0042903	tubulin deacetylase activity	HDAC6	IDA		Human	PMID:19228685
Molecular Function	GO:0042903	tubulin deacetylase activity	HDAC6	IMP		Human	PMID:19457097
Molecular Function	GO:0042903	tubulin deacetylase activity	HDAC6	IDA		Human	PMID:20308065
Molecular Function	GO:0042903	tubulin deacetylase activity	Hdac6	IMP		Mouse	MGI:MGI:6119868|PMID:19457097
Molecular Function	GO:0042903	tubulin deacetylase activity	Hdac6	IGI	UniProtKB:Q5EG47,UniProtKB:Q8BRK8	Mouse	MGI:MGI:6148443|PMID:27430620
Molecular Function	GO:0042903	tubulin deacetylase activity	Hdac6	IDA		Mouse	MGI:MGI:4820954|PMID:19893491
Molecular Function	GO:0042903	tubulin deacetylase activity	Hdac6	IDA		Mouse	PMID:12606581
Molecular Function	GO:0042903	tubulin deacetylase activity	hdac6	IDA		Zfish	PMID:27454931
Molecular Function	GO:0043130	ubiquitin binding	Hdac6	IDA		Mouse	PMID:11689694
Molecular Function	GO:0043130	ubiquitin binding	Hdac6	IDA		Mouse	PMID:16810319
Molecular Function	GO:0031625	ubiquitin protein ligase binding	HDAC6	IPI	UniProtKB:O60260	Human	PMID:21753002
Molecular Function	GO:0008270	zinc ion binding	hdac6	IDA		Zfish	PMID:27454931
Molecular Function	GO:0008270	zinc ion binding	hdac6	IDA		Zfish	PMID:27454933
Cellular Component	GO:0016235	aggresome	HDAC6	IDA		Human	PMID:14675537
Cellular Component	GO:0030424	axon	Hdac6	IDA		Mouse	MGI:MGI:5567913|PMID:16933150
Cellular Component	GO:0005901	caveola	HDAC6	IDA		Human	PMID:18356165
Cellular Component	GO:0031252	cell leading edge	HDAC6	IDA		Human	PMID:12024216
Cellular Component	GO:0005813	centrosome	HDAC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0036064	ciliary basal body	HDAC6	IDA		Human	PMID:17604723
Cellular Component	GO:0005737	cytoplasm	HDAC6	IDA		Human	PMID:24687993
Cellular Component	GO:0005737	cytoplasm	Hdac6	IDA		Mouse	PMID:11689694
Cellular Component	GO:0005829	cytosol	HDAC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Hdac6	IDA		Mouse	MGI:MGI:4820954|PMID:19893491
Cellular Component	GO:0030425	dendrite	Hdac6	IDA		Mouse	MGI:MGI:5567913|PMID:16933150
Cellular Component	GO:0000118	histone deacetylase complex	HDAC6	IDA		Human	PMID:11948178
Cellular Component	GO:0016234	inclusion body	HDAC6	IDA		Human	PMID:16192271
Cellular Component	GO:0005874	microtubule	HDAC6	IDA		Human	PMID:12620231
Cellular Component	GO:0005875	microtubule associated complex	HDAC6	IDA		Human	PMID:19228685
Cellular Component	GO:0015630	microtubule cytoskeleton	Hdac6	IDA		Mouse	PMID:12606581
Cellular Component	GO:0043005	neuron projection	Hdac6	IDA		Mouse	PMID:24113571
Cellular Component	GO:0043025	neuronal cell body	Hdac6	IDA		Mouse	PMID:24113571
Cellular Component	GO:0005654	nucleoplasm	HDAC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Hdac6	IDA		Mouse	MGI:MGI:4820954|PMID:19893491
Cellular Component	GO:0043204	perikaryon	Hdac6	IDA		Mouse	MGI:MGI:5567913|PMID:16933150
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HDAC6	IDA		Human	PMID:12024216
Cellular Component	GO:0032991	protein-containing complex	Hdac6	IPI	UniProtKB:P38532	Mouse	PMID:17785525
Cellular Component	GO:0032991	protein-containing complex	Hdac6	IPI	PR:Q01853	Mouse	PMID:17785525
Biological Process	GO:0070842	aggresome assembly	HDAC6	IMP		Human	PMID:14675537
Biological Process	GO:0070842	aggresome assembly	Hdac6	IGI	MGI:MGI:99919	Mouse	PMID:16810319
Biological Process	GO:0001525	angiogenesis	hdac6	IMP	ZFIN:ZDB-MRPHLNO-111111-2	Zfish	PMID:21847094
Biological Process	GO:0001525	angiogenesis	hdac6	IGI	ZFIN:ZDB-GENE-040426-1610,ZFIN:ZDB-MRPHLNO-111111-1	Zfish	PMID:21847094
Biological Process	GO:0001525	angiogenesis	hdac6	IMP	ZFIN:ZDB-MRPHLNO-111111-1	Zfish	PMID:21847094
Biological Process	GO:0019896	axonal transport of mitochondrion	HDAC6	IGI	UniProtKB:O75506	Human	PMID:28105056
Biological Process	GO:0070301	cellular response to hydrogen peroxide	HDAC6	IMP		Human	PMID:18606987
Biological Process	GO:0071218	cellular response to misfolded protein	Hdac6	IMP	MGI:MGI:3776868	Mouse	PMID:17785525
Biological Process	GO:0035967	cellular response to topologically incorrect protein	HDAC6	IMP		Human	PMID:16192271
Biological Process	GO:0061523	cilium disassembly	HDAC6	IMP		Human	PMID:17604723
Biological Process	GO:0048668	collateral sprouting	Hdac6	IMP		Mouse	PMID:24113571
Biological Process	GO:0060216	definitive hemopoiesis	hdac6	IMP	ZFIN:ZDB-MRPHLNO-141229-18	Zfish	PMID:24240475
Biological Process	GO:0060997	dendritic spine morphogenesis	Hdac6	IMP		Mouse	PMID:24113571
Biological Process	GO:0040029	epigenetic regulation of gene expression	HDAC6	IMP		Human	PMID:24413532
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	hdac6	IMP		Zfish	PMID:24240475
Biological Process	GO:0016575	histone deacetylation	HDAC6	IDA		Human	PMID:10220385
Biological Process	GO:0070846	Hsp90 deacetylation	Hdac6	IMP	MGI:MGI:3776868	Mouse	PMID:17785525
Biological Process	GO:0006886	intracellular protein transport	HDAC6	IMP		Human	PMID:16192271
Biological Process	GO:0032418	lysosome localization	HDAC6	IMP		Human	PMID:16192271
Biological Process	GO:0051646	mitochondrion localization	Hdac6	IMP		Mouse	MGI:MGI:5616310|PMID:20457763
Biological Process	GO:0014902	myotube differentiation	Hdac6	IMP		Mouse	PMID:22174839
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	Hdac6	IDA		Mouse	PMID:12486003
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	HDAC6	IMP		Human	PMID:23962722
Biological Process	GO:0043242	negative regulation of protein-containing complex disassembly	HDAC6	IMP		Human	PMID:15916966
Biological Process	GO:0045861	negative regulation of proteolysis	HDAC6	IMP		Human	PMID:18356165
Biological Process	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	HDAC6	IGI	UniProtKB:Q9JK66,UniProtKB:Q9Z2V5	Human	PMID:20457763
Biological Process	GO:0034983	peptidyl-lysine deacetylation	HDAC6	IMP		Human	PMID:18356165
Biological Process	GO:0034983	peptidyl-lysine deacetylation	HDAC6	IMP		Human	PMID:18606987
Biological Process	GO:0034983	peptidyl-lysine deacetylation	HDAC6	IMP		Human	PMID:23962722
Biological Process	GO:0034983	peptidyl-lysine deacetylation	Hdac6	IMP		Mouse	MGI:MGI:6114855|PMID:23962722
Biological Process	GO:0070845	polyubiquitinated misfolded protein transport	HDAC6	IMP		Human	PMID:14675537
Biological Process	GO:0010634	positive regulation of epithelial cell migration	HDAC6	IMP		Human	PMID:12024216
Biological Process	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	HDAC6	IDA		Human	PMID:18606987
Biological Process	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	Hdac6	IGI	UniProtKB:Q9JK66	Mouse	MGI:MGI:5616310|PMID:20457763
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	HDAC6	IMP		Human	PMID:23962722
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Hdac6	IMP		Mouse	MGI:MGI:6114855|PMID:23962722
Biological Process	GO:2000273	positive regulation of signaling receptor activity	HDAC6	IMP		Human	PMID:15916966
Biological Process	GO:2000273	positive regulation of signaling receptor activity	HDAC6	IMP		Human	PMID:18316616
Biological Process	GO:0006476	protein deacetylation	HDAC6	IMP		Human	PMID:15916966
Biological Process	GO:0006476	protein deacetylation	HDAC6	IDA		Human	PMID:28516954
Biological Process	GO:0006476	protein deacetylation	Hdac6	IDA		Mouse	PMID:12486003
Biological Process	GO:0006476	protein deacetylation	hdac6	IGI	ZFIN:ZDB-GENE-040426-1610	Zfish	PMID:21847094
Biological Process	GO:0031648	protein destabilization	Hdac6	IMP		Mouse	MGI:MGI:5605128|PMID:24882211
Biological Process	GO:0000209	protein polyubiquitination	Hdac6	IDA		Mouse	PMID:11689694
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HDAC6	IMP		Human	PMID:14675537
Biological Process	GO:0032984	protein-containing complex disassembly	Hdac6	IGI	MGI:MGI:96238	Mouse	PMID:17785525
Biological Process	GO:0032984	protein-containing complex disassembly	Hdac6	IGI	MGI:MGI:99919	Mouse	PMID:17785525
Biological Process	GO:0070201	regulation of establishment of protein localization	Hdac6	IMP		Mouse	PMID:22792322
Biological Process	GO:0045598	regulation of fat cell differentiation	Hdac6	IMP		Mouse	PMID:23126280
Biological Process	GO:0016241	regulation of macroautophagy	HDAC6	IMP		Human	PMID:16192271
Biological Process	GO:0031647	regulation of protein stability	HDAC6	IMP		Human	PMID:23580651
Biological Process	GO:0070848	response to growth factor	HDAC6	IMP		Human	PMID:18356165
Biological Process	GO:0051788	response to misfolded protein	HDAC6	IMP		Human	PMID:14675537
Biological Process	GO:0007519	skeletal muscle tissue development	Hdac6	IMP		Mouse	PMID:22174839
Biological Process	GO:0090042	tubulin deacetylation	HDAC6	IDA		Human	PMID:19228685
Biological Process	GO:0090042	tubulin deacetylation	HDAC6	IDA		Human	PMID:20308065
Biological Process	GO:0090042	tubulin deacetylation	HDAC6	IDA		Human	PMID:23093407
Biological Process	GO:0090042	tubulin deacetylation	Hdac6	IDA		Mouse	MGI:MGI:4820954|PMID:19893491
Biological Process	GO:0090042	tubulin deacetylation	Hdac6	IMP		Mouse	PMID:12606581
Biological Process	GO:0090042	tubulin deacetylation	Hdac6	IMP	MGI:MGI:3776868	Mouse	PMID:16810319
Biological Process	GO:0090042	tubulin deacetylation	Hdac6	IMP	MGI:MGI:3776868	Mouse	PMID:17785525
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Hdac6	IMP	MGI:MGI:3776868	Mouse	PMID:16810319
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Hdac6	IGI	MGI:MGI:99919	Mouse	PMID:16810319
Biological Process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	Hdac6	IMP	MGI:MGI:3776868	Mouse	PMID:17785525

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern