Hdac6
Gene Detail

Symbol Name ID

Hdac6 histone deacetylase 6 MGI:1333752

Synonyms

mHDA2, Sfc6

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:7930120-7947889 bp, - strand From VEGA annotation of GRCm38   17770 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Hdac6

Human homologs

Human Homolog		HDAC6, histone deacetylase 6
NCBI Gene ID		10013
neXtProt AC		NX_Q9UBN7
Human Synonyms		HD6
Human Chr (Location)		Xp11.23; chrX:48660487-48683380 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(4)
 

Although mice homozygous for a knock-out allele exhibit global tubulin hyperacetylation, they are viable and fertile and display only a moderately impaired immune response and a minor increase in cancellous bone mineral density.

 

Gene Ontology (GO) classifications

All GO classifications: (88 annotations)

Process	aggresome assembly, cellular response to hydrogen peroxide, ...
Component	aggresome, caveola, ...
Function	actin binding, alpha-tubulin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (121)    Tissues (37)    Images (30)
Theiler Stages: 2, 3, 19, 23, 28

Assay Type	Results
RNA in situ	85
RT-PCR	36

cDNA source data(132)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(136) Genomic(2) cDNA(132) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017170 (Evidence)
Ensembl Gene Model	ENSMUSG00000031161 (Evidence)
Entrez Gene	15185 (Evidence)
UniGene	29854
DFCI	TC1575832, TC1588463, TC1702433
DoTS	DT.101310625, DT.530998, DT.99858495
NIA Mouse Gene Index	U039235
EC	3.5.1.98
Consensus CDS Project	CCDS40845.1
International Mouse Knockout Project Status	Hdac6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017170	VEGA Gene Model | MGI Sequence Detail	17770	C57BL/6J
transcript	OTTMUST00000041586	VEGA | MGI Sequence Detail	4069	Not Applicable
polypeptide	OTTMUSP00000018679	VEGA | MGI Sequence Detail	1149	Not Applicable

All sequences(69) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023801	Histone deacetylase domain
InterPro	IPR000286	Histone deacetylase superfamily
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001607	Zinc finger, UBP-type
Protein Ontology	PR:000008485	histone deacetylase 6

References

(Earliest) J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
(Latest) J:189648 Fusco C, et al., The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS One. 2012;7(7):e40440
All references(68)

Other accession IDs

MGI:1343096