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Hdac6 Gene Detail
Summary
  • Symbol
    Hdac6
  • Name
    histone deacetylase 6
  • Synonyms
    mHDA2, Sfc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333752
    NCBI Gene: 15185
  • Gene Overview
    MyGene.info: HDAC6
Location & Maps
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  • Genetic Map
    Chromosome X, 3.58 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
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  • Human Ortholog
    HDAC6, histone deacetylase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HDAC6, histone deacetylase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPBHM, HD6, JM21, PPP1R90
  • Links
    NCBI Gene ID: 10013
    neXtProt AC: NX_Q9UBN7

  • Chr Location
    Xp11.23; chrX:48801896-48824976 (+)  GRCh38.p2

Human Diseases
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  • Diseases
    1 with human HDAC6 associations

Human Disease Mouse Models
       Chondrodysplasia with Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, and Microphthalmia   OMIM: 300863
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    4
  • Targeted
    7
  • Incidental Mutations
    APF
Although mice homozygous for a knock-out allele exhibit global tubulin hyperacetylation, they are viable and fertile and display only a moderately impaired immune response and a minor increase in cancellous bone mineral density.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017170 VEGA Gene Model | MGI Sequence Detail 17770 C57BL/6J ±  kb
transcript OTTMUST00000041586 VEGA | MGI Sequence Detail 4069 Not Applicable  
polypeptide OTTMUSP00000018679 VEGA | MGI Sequence Detail 1149 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 136
    Genomic 2
    cDNA 132
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1343096
References
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  • Summaries
    All 88
    Developmental Gene Expression 9
    Gene Ontology 19
    Phenotypes 20
  • Earliest
    J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
  • Latest
    J:230670 Matthews GM, et al., Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood. 2015 Nov 19;126(21):2392-403

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory