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Hdac6
Gene Detail
 Symbol
Name
ID
Hdac6
histone deacetylase 6
MGI:1333752
Synonyms mHDA2, Sfc6
Feature Type protein coding gene
Genetic Map
Chromosome X
3.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:7930120-7947889 bp, - strand
From VEGA annotation of GRCm38

  17770 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31353  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Hdac6

Human
homologs
Human Homolog HDAC6, histone deacetylase 6
NCBI Gene ID 10013
neXtProt AC  NX_Q9UBN7
Human Synonyms  CPBHM, HD6, PPP1R90
Human Chr (Location)  Xp11.23; chrX:48801679-48824976 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HDAC6
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from APF )
 
Although mice homozygous for a knock-out allele exhibit global tubulin hyperacetylation, they are viable and fertile and display only a moderately impaired immune response and a minor increase in cancellous bone mineral density.
 
Interactions
Hdac6 interacts with 65 markers (Mir18, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (95 annotations)
Process aggresome assembly, cellular response to hydrogen peroxide, ...
Component aggresome, axon, ...
Function actin binding, alpha-tubulin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (121)    Tissues (37)    Images (30)
Theiler Stages: 2, 3, 19, 23, 28
Assay TypeResults
RNA in situ 85
RT-PCR 36
cDNA source data(132)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(136) Genomic(2) cDNA(132) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017170 (Evidence)
Ensembl Gene ModelENSMUSG00000031161 (Evidence)
Entrez Gene15185 (Evidence)
UniGene29854
DFCITC1575832, TC1588463, TC1702433
DoTSDT.101310625, DT.530998, DT.99858495
NIA Mouse Gene IndexU039235
EC3.5.1.98
Consensus CDS ProjectCCDS40845.1
International Mouse Knockout Project StatusHdac6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017170 VEGA Gene Model | MGI Sequence Detail 17770 C57BL/6J ±  kb
transcript OTTMUST00000041586 VEGA | MGI Sequence Detail 4069 Not Applicable 
polypeptide OTTMUSP00000018679 VEGA | MGI Sequence Detail 1149 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(6) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001607 Zinc finger, UBP-type
Protein Ontology PR:000008485 histone deacetylase 6
References (Earliest) J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
(Latest) J:207921 Chen PB, et al., Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013;2:e01557
All references(76)
Other
accession IDs
MGI:1343096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory