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Hdac6
Gene Detail
Symbol

Name
ID
Hdac6
histone deacetylase 6
MGI:1333752
Synonyms
mHDA2, Sfc6
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:7930120-7947889 bp, - strand
From VEGA annotation of GRCm38

  17770 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31353  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HDAC6
Gene Tree: Hdac6

Human
homologs
HDAC6, histone deacetylase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10013
neXtProt AC: NX_Q9UBN7

Human Synonyms: CPBHM, HD6, JM21, PPP1R90

Human Chr (Location): Xp11.23; chrX:48801896-48824976 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HDAC6

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from APF )
 
Although mice homozygous for a knock-out allele exhibit global tubulin hyperacetylation, they are viable and fertile and display only a moderately impaired immune response and a minor increase in cancellous bone mineral density.
 
Interactions
Hdac6 interacts with 65 markers (Mir18, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (98 annotations)
Process activation of mitophagy in response to mitochondrial depolarization, aggresome assembly, ...
Component aggresome, axon, ...
Function actin binding, alpha-tubulin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (121)    Tissues (37)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 85
RT-PCR 36
cDNA source data(132)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hdac6    NEW 
Molecular
reagents
All nucleic(136) Genomic(2) cDNA(132) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017170 (Evidence)
Ensembl Gene Model ENSMUSG00000031161 (Evidence)
Entrez Gene 15185 (Evidence)
UniGene 29854
DFCI TC1588463, TC1575832, TC1702433
DoTS DT.101310625, DT.99858495, DT.530998
NIA Mouse Gene Index U039235
EC 3.5.1.98
Consensus CDS Project CCDS40845.1
International Mouse Phenotyping Consortium Status Hdac6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017170 VEGA Gene Model | MGI Sequence Detail 17770 C57BL/6J ±  kb
transcript OTTMUST00000041586 VEGA | MGI Sequence Detail 4069 Not Applicable 
polypeptide OTTMUSP00000018679 VEGA | MGI Sequence Detail 1149 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001607 Zinc finger, UBP-type
Protein Ontology PR:000008485 histone deacetylase 6
References
(Earliest) J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
(Latest) J:218417 Lee JY, et al., MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria. J Cell Sci. 2014 Nov 15;127(22):4954-63
All references(81)
Other
accession IDs
MGI:1343096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory