About   Help   FAQ
Hdac6 Gene Detail
Summary
  • Symbol
    Hdac6
  • Name
    histone deacetylase 6
  • Synonyms
    mHDA2, Sfc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333752
    NCBI Gene: 15185
  • Gene Overview
    MyGene.info: HDAC6
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7930120-7947889 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333752
protein coding gene ChrX:7930116-7948016 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035535
protein coding gene ChrX:2556586-2576039 (-)
A/J MGP_AJ_G0035512
protein coding gene ChrX:2514370-2533277 (-)
AKR/J MGP_AKRJ_G0035445
protein coding gene ChrX:2634925-2654674 (-)
BALB/cJ MGP_BALBcJ_G0035509
protein coding gene ChrX:2542523-2560204 (-)
C3H/HeJ MGP_C3HHeJ_G0035217
protein coding gene ChrX:2605595-2623962 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036033
protein coding gene ChrX:2644266-2662254 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032908
protein coding gene ChrX:2075960-2093704 (-)
CAST/EiJ MGP_CASTEiJ_G0034518
protein coding gene ChrX:2495620-2516910 (-)
CBA/J MGP_CBAJ_G0035187
protein coding gene ChrX:2769249-2789347 (-)
DBA/2J MGP_DBA2J_G0035344
protein coding gene ChrX:2537639-2555428 (-)
FVB/NJ MGP_FVBNJ_G0035291
protein coding gene ChrX:2499322-2516965 (-)
LP/J MGP_LPJ_G0035421
protein coding gene ChrX:2579840-2597606 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035331
protein coding gene ChrX:2733019-2751638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036051
protein coding gene ChrX:2542649-2562396 (-)
PWK/PhJ MGP_PWKPhJ_G0034218
protein coding gene ChrX:2468643-2486527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034057
protein coding gene ChrX:2519849-2538599 (-)
WSB/EiJ MGP_WSBEiJ_G0034641
protein coding gene ChrX:2550674-2569511 (-)



Homology
more
  • Human Ortholog
    HDAC6, histone deacetylase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HDAC6, histone deacetylase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPBHM, HD6, JM21, PPP1R90
  • Links
    NCBI Gene ID: 10013
    neXtProt AC: NX_Q9UBN7
    UniProt: Q9UBN7

  • Chr Location
    Xp11.23; chrX:48801377-48824982 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Although mice homozygous for a knock-out allele exhibit global tubulin hyperacetylation, they are viable and fertile and display only a moderately impaired immune response and a minor increase in cancellous bone mineral density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031161 Ensembl Gene Model | MGI Sequence Detail 17770 C57BL/6J ±  kb
    transcript ENSMUST00000033501 Ensembl | MGI Sequence Detail 4142 Not Applicable  
    polypeptide ENSMUSP00000033501 Ensembl | MGI Sequence Detail 1149 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      Genomic 2
      cDNA 133
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1343096
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 13
      Gene Ontology 23
      Phenotypes 31
    • Earliest
      J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
    • Latest
      J:259704 Mo Z, et al., Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018 Mar 8;9(1):1007

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory