Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GHRL
  • Mouse genes Ghrl
  • Rat genes Ghrl
  • Zfish genes ghrl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ghrl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	Ghrl	IPI	UniProtKB:O08725	Rat	PMID:10604470|RGD:625505
Molecular Function	GO:0031768	ghrelin receptor binding	Ghrl	IMP		Rat	PMID:17109695|RGD:1624382
Molecular Function	GO:0016608	growth hormone-releasing hormone activity	Ghrl	IDA		Rat	PMID:10604470|RGD:625505
Molecular Function	GO:0016608	growth hormone-releasing hormone activity	Ghrl	IDA		Rat	PMID:17060681|RGD:1624396
Molecular Function	GO:0005179	hormone activity	Ghrl	IDA		Rat	PMID:17109695|RGD:1624382
Molecular Function	GO:0005515	protein binding	GHRL	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GHRL	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GHRL	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	GHRL	IMP		Human	PMID:15350694
Cellular Component	GO:0030424	axon	GHRL	IDA		Human	PMID:17113048
Cellular Component	GO:0005737	cytoplasm	Ghrl	IDA		Mouse	PMID:10930375
Cellular Component	GO:0005737	cytoplasm	Ghrl	IDA		Rat	PMID:15155262|RGD:12905047
Cellular Component	GO:0005576	extracellular region	GHRL	IDA		Human	PMID:17392603
Cellular Component	GO:0005576	extracellular region	Ghrl	IDA		Mouse	PMID:10930375
Cellular Component	GO:0005615	extracellular space	GHRL	IDA		Human	PMID:15039149
Cellular Component	GO:0005615	extracellular space	GHRL	IDA		Human	PMID:15531532
Cellular Component	GO:0098978	glutamatergic synapse	Ghrl	IDA		Rat	PMID:22516464|RGD:13702295
Cellular Component	GO:0098978	glutamatergic synapse	Ghrl	IMP		Rat	PMID:22516464|RGD:13702295
Cellular Component	GO:0098978	glutamatergic synapse	Ghrl	IDA		Rat	PMID:26153524|RGD:13702301
Cellular Component	GO:0098978	glutamatergic synapse	Ghrl	IMP		Rat	PMID:26153524|RGD:13702301
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ghrl	IDA		Rat	PMID:26153524|RGD:13702301
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ghrl	IMP		Rat	PMID:26153524|RGD:13702301
Biological Process	GO:0008154	actin polymerization or depolymerization	GHRL	IDA		Human	PMID:15232612
Biological Process	GO:0008343	adult feeding behavior	Ghrl	IDA		Mouse	MGI:MGI:3612647|PMID:16322794
Biological Process	GO:0043009	chordate embryonic development	ghrl	IMP	ZFIN:ZDB-MRPHLNO-090819-2	Zfish	PMID:19264876
Biological Process	GO:0043009	chordate embryonic development	ghrl	IMP	ZFIN:ZDB-MRPHLNO-090819-1	Zfish	PMID:19264876
Biological Process	GO:0046697	decidualization	GHRL	IDA		Human	PMID:17494105
Biological Process	GO:0016358	dendrite development	GHRL	IDA		Human	PMID:16491079
Biological Process	GO:0016358	dendrite development	Ghrl	IMP	MGI:MGI:3045041	Mouse	PMID:16491079
Biological Process	GO:0060079	excitatory postsynaptic potential	Ghrl	IMP	MGI:MGI:3045041	Mouse	PMID:16491079
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ghrl	IDA		Rat	PMID:10604470|RGD:625505
Biological Process	GO:0001696	gastric acid secretion	Ghrl	IDA		Rat	PMID:17705669|RGD:8553549
Biological Process	GO:0035483	gastric emptying	Ghrl	IDA		Rat	PMID:15890336|RGD:12907565
Biological Process	GO:0007507	heart development	ghrl	IMP	ZFIN:ZDB-MRPHLNO-090819-1	Zfish	PMID:19264876
Biological Process	GO:0043066	negative regulation of apoptotic process	GHRL	IDA		Human	PMID:15158140
Biological Process	GO:0043066	negative regulation of apoptotic process	Ghrl	IDA		Rat	PMID:17543279|RGD:6907130
Biological Process	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	GHRL	IDA		Human	PMID:18329818
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	GHRL	IDA		Human	PMID:15572208
Biological Process	GO:0050728	negative regulation of inflammatory response	GHRL	IDA		Human	PMID:15232612
Biological Process	GO:0046676	negative regulation of insulin secretion	Ghrl	IMP	MGI:MGI:3709886	Mouse	PMID:17130496
Biological Process	GO:0046676	negative regulation of insulin secretion	Ghrl	IDA		Rat	PMID:17130496|RGD:8553721
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	GHRL	IDA		Human	PMID:15232612
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Ghrl	IDA		Rat	PMID:19620309|RGD:12905041
Biological Process	GO:0032715	negative regulation of interleukin-6 production	GHRL	IDA		Human	PMID:15232612
Biological Process	GO:0040013	negative regulation of locomotion	Ghrl	IMP	MGI:MGI:3045041	Mouse	PMID:16322795
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	GHRL	IDA		Human	PMID:15232612
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Ghrl	IDA		Rat	PMID:19620309|RGD:12905041
Biological Process	GO:1904179	positive regulation of adipose tissue development	Ghrl	IDA		Rat	PMID:14551228|RGD:12904887
Biological Process	GO:0032100	positive regulation of appetite	Ghrl	IDA		Mouse	MGI:MGI:3612647|PMID:16322794
Biological Process	GO:0032100	positive regulation of appetite	Ghrl	IDA		Mouse	PMID:15070777
Biological Process	GO:0032100	positive regulation of appetite	Ghrl	IGI	MGI:MGI:2441906	Mouse	PMID:15070777
Biological Process	GO:0032100	positive regulation of appetite	Ghrl	IMP	MGI:MGI:3045041	Mouse	PMID:17060947
Biological Process	GO:0032100	positive regulation of appetite	Ghrl	IMP		Rat	PMID:15994217|RGD:12904962
Biological Process	GO:1903012	positive regulation of bone development	Ghrl	IDA		Rat	PMID:12960077|RGD:12905040
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	GHRL	IDA		Human	PMID:18329818
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Ghrl	IMP		Mouse	MGI:MGI:4355630|PMID:19666521
Biological Process	GO:0051461	positive regulation of corticotropin secretion	GHRL	IDA		Human	PMID:12566947
Biological Process	GO:0051464	positive regulation of cortisol secretion	GHRL	IDA		Human	PMID:12566947
Biological Process	GO:0051464	positive regulation of cortisol secretion	GHRL	IDA		Human	PMID:18329818
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Ghrl	IDA		Rat	PMID:11756331|RGD:8554453
Biological Process	GO:1904000	positive regulation of eating behavior	Ghrl	IDA		Rat	PMID:14551228|RGD:12904887
Biological Process	GO:2000253	positive regulation of feeding behavior	Ghrl	IDA		Rat	PMID:17033095|RGD:12910734
Biological Process	GO:1904346	positive regulation of gastric mucosal blood circulation	Ghrl	IDA		Rat	PMID:17033095|RGD:12910734
Biological Process	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	Ghrl	IDA		Rat	PMID:15890336|RGD:12907565
Biological Process	GO:0045927	positive regulation of growth	Ghrl	IDA		Rat	PMID:12960077|RGD:12905040
Biological Process	GO:0060124	positive regulation of growth hormone secretion	GHRL	IDA		Human	PMID:12566947
Biological Process	GO:0060124	positive regulation of growth hormone secretion	GHRL	IDA		Human	PMID:18329818
Biological Process	GO:0060124	positive regulation of growth hormone secretion	Ghrl	IDA		Rat	PMID:10604470|RGD:625505
Biological Process	GO:0040010	positive regulation of growth rate	Ghrl	IDA		Rat	PMID:17033095|RGD:12910734
Biological Process	GO:0032024	positive regulation of insulin secretion	Ghrl	IDA		Rat	PMID:11756331|RGD:8554453
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Ghrl	IDA		Rat	PMID:16647196|RGD:12905046
Biological Process	GO:0043410	positive regulation of MAPK cascade	GHRL	IMP		Human	PMID:15350694
Biological Process	GO:0032097	positive regulation of response to food	Ghrl	IDA		Rat	PMID:17065340|RGD:1624395
Biological Process	GO:0120058	positive regulation of small intestinal transit	Ghrl	IDA		Rat	PMID:21874246|RGD:12910732
Biological Process	GO:1904349	positive regulation of small intestine smooth muscle contraction	Ghrl	IDA		Rat	PMID:15890336|RGD:12907565
Biological Process	GO:1904349	positive regulation of small intestine smooth muscle contraction	Ghrl	IDA		Rat	PMID:21874246|RGD:12910732
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	Ghrl	IDA		Rat	PMID:21642627|RGD:12904963
Biological Process	GO:0051965	positive regulation of synapse assembly	GHRL	IDA		Human	PMID:16491079
Biological Process	GO:0051965	positive regulation of synapse assembly	Ghrl	IMP	MGI:MGI:3045041	Mouse	PMID:16491079
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	Ghrl	IDA		Rat	PMID:21642627|RGD:12904963
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ghrl	IDA		Rat	PMID:26153524|RGD:13702301
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ghrl	IMP		Rat	PMID:26153524|RGD:13702301
Biological Process	GO:0042127	regulation of cell population proliferation	GHRL	IDA		Human	PMID:15564328
Biological Process	GO:0042127	regulation of cell population proliferation	GHRL	IDA		Human	PMID:16394173
Biological Process	GO:1905333	regulation of gastric motility	Ghrl	IDA		Rat	PMID:23525979|RGD:12907567
Biological Process	GO:0099175	regulation of postsynapse organization	Ghrl	IDA		Rat	PMID:22516464|RGD:13702295
Biological Process	GO:0099175	regulation of postsynapse organization	Ghrl	IMP		Rat	PMID:22516464|RGD:13702295
Biological Process	GO:0032095	regulation of response to food	Ghrl	IDA		Rat	PMID:17065340|RGD:1624395
Biological Process	GO:0032095	regulation of response to food	ghrl	IDA		Zfish	PMID:19027742
Biological Process	GO:0051969	regulation of transmission of nerve impulse	Ghrl	IDA		Rat	PMID:23525979|RGD:12907567
Biological Process	GO:0051602	response to electrical stimulus	Ghrl	IEP		Rat	PMID:23525979|RGD:12907567
Biological Process	GO:0043627	response to estrogen	GHRL	IDA		Human	PMID:15292338
Biological Process	GO:0032094	response to food	ghrl	IDA		Zfish	PMID:26226634
Biological Process	GO:0009725	response to hormone	GHRL	IDA		Human	PMID:15232612
Biological Process	GO:0031667	response to nutrient levels	Ghrl	IEP		Rat	PMID:26512025|RGD:12904888
Biological Process	GO:0007416	synapse assembly	Ghrl	IMP	MGI:MGI:3045041	Mouse	PMID:16491079

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern