Ghrl
Gene Detail

Symbol Name ID

Ghrl ghrelin MGI:1930008

Synonyms

2210006E23Rik, Ghr, m46, MTLRP, MTLRPAP

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.84 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:113716119-113719880 bp, - strand From NCBI annotation of GRCm38   3762 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9487  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: motilin
Gene Tree: Ghrl

Human homologs

Human Homolog		GHRL, ghrelin/obestatin prepropeptide
NCBI Gene ID		51738
neXtProt AC		NX_Q9UBU3
Human Synonyms		MTLRP
Human Chr (Location)		3p26-p25; chr3:10327434-10334631 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GHRL

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for most disruptions in this gene display no phenotypic abnormalities on a regular diet and increased utilization of fat as an energy substrate on a high fat diet. Mice homozygous for one allele display age-dependent changes in stimulated food intake and metabolism.

 

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	actin polymerization or depolymerization, activation of MAPK activity, ...
Component	axon, cytoplasm, ...
Function	ghrelin receptor binding, G-protein coupled receptor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (52 records)
Data Summary: Results (111)    Tissues (98)    Images (14)
Theiler Stages: 22, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	95
Northern blot	12

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000064177 (Evidence)
Entrez Gene	58991 (Evidence)
UniGene	379095
DFCI	TC1585492, TC1591740, TC1720080
DoTS	DT.101158332, DT.103560034, DT.50316838
NIA Mouse Gene Index	U027740
PDB	2JSH, 2JSI, 2JSJ
Consensus CDS Project	CCDS20432.1
International Mouse Knockout Project Status	Ghrl

Sequences

Length	Strain/Species
genomic	58991	NCBI Gene Model | MGI Sequence Detail	3762	C57BL/6J
transcript	NM_021488	RefSeq | MGI Sequence Detail	527	C57BL/6
polypeptide	Q9EQX0	UniProt | EBI | MGI Sequence Detail	117	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006738	Motilin/ghrelin
InterPro	IPR006737	Motilin/ghrelin-associated peptide
InterPro	IPR005441	Preproghrelin peptide
Protein Ontology	PR:000007973	appetite-regulating hormone

Graphical View of Protein Domain Structure

References

(Earliest) J:63705 Tomasetto C, et al., Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology. 2000 Aug;119(2):395-405
(Latest) J:192421 Lamont EW, et al., Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm. Neuroscience. 2012 Aug 30;218:12-9
All references(132)

Other accession IDs

MGI:1914343