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Ghrl
Gene Detail
Symbol

Name
ID
Ghrl
ghrelin
MGI:1930008
Synonyms
2210006E23Rik, Ghr, m46, MTLRP, MTLRPAP
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.84 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:113716119-113719880 bp, - strand
From Ensembl annotation of GRCm38

  3762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9487  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: motilin
Gene Tree: Ghrl

Human
homologs
Human Homolog GHRL, ghrelin/obestatin prepropeptide
NCBI Gene ID 51738
neXtProt AC  NX_Q9UBU3
Human Synonyms  MTLRP
Human Chr (Location)  3p26-p25; chr3:10285750-10292947 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GHRL
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for most disruptions in this gene display no phenotypic abnormalities on a regular diet and increased utilization of fat as an energy substrate on a high fat diet. Mice homozygous for one allele display age-dependent changes in stimulated food intake and metabolism.
 
Interactions
Ghrl interacts with 22 markers (Mir20a, Mir96, Mir106b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process actin polymerization or depolymerization, activation of MAPK activity, ...
Component axon, cytoplasm, ...
Function ghrelin receptor binding, G-protein coupled receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (111)    Tissues (99)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 95
Northern blot 12
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000064177 (Evidence)
Entrez Gene58991 (Evidence)
UniGene379095
DFCITC1720080, TC1591740, TC1585492
DoTSDT.101158332, DT.103560034, DT.50316838
NIA Mouse Gene IndexU027740
PDB2JSJ, 2JSI, 2JSH
Consensus CDS ProjectCCDS20432.1
International Mouse Knockout Project StatusGhrl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064177 Ensembl Gene Model | MGI Sequence Detail 3762 C57BL/6J ±  kb
transcript ENSMUST00000064993 Ensembl | MGI Sequence Detail 527 Not Applicable 
polypeptide ENSMUSP00000069567 Ensembl | MGI Sequence Detail 117 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006738 Motilin/ghrelin
InterPro IPR006737 Motilin/ghrelin-associated peptide
InterPro IPR005441 Preproghrelin peptide
Protein Ontology PR:000007973 appetite-regulating hormone
References
(Earliest) J:63705 Tomasetto C, et al., Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology. 2000 Aug;119(2):395-405
(Latest) J:214261 Lin D, et al., Abnormal response to the anorexic effect of GHS-R inhibitors and exenatide in male Snord116 deletion mouse model for Prader-Willi syndrome. Endocrinology. 2014 Jul;155(7):2355-62
All references(151)
Other
accession IDs
MGI:1914343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory