About   Help   FAQ
Ghrl Gene Detail
Summary
  • Symbol
    Ghrl
  • Name
    ghrelin
  • Synonyms
    2210006E23Rik, Ghr, m46, MTLRP, MTLRPAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930008
    NCBI Gene: 58991
Location & Maps
more
  • Sequence Map
    Chr6:113716119-113719880 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3762 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GHRL, ghrelin/obestatin prepropeptide
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GHRL, ghrelin/obestatin prepropeptide
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MTLRP
  • Links
    NCBI Gene ID: 51738
    neXtProt AC: NX_Q9UBU3

  • Chr Location
    3p26-p25; chr3:10285750-10292947 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GHRL associations

Human Disease Mouse Models
       Obesity   OMIM: 601665
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Spontaneous
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    1 involving Ghrl
  • Incidental Mutations
Mice homozygous for most disruptions in this gene display no phenotypic abnormalities on a regular diet and increased utilization of fat as an energy substrate on a high fat diet. Mice homozygous for one allele display age-dependent changes in stimulatedfood intake and metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064177 Ensembl Gene Model | MGI Sequence Detail 3762 C57BL/6J ±  kb
transcript ENSMUST00000064993 Ensembl | MGI Sequence Detail 527 Not Applicable  
polypeptide ENSMUSP00000069567 Ensembl | MGI Sequence Detail 117 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 12
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914343
References
more
  • Summaries
    All 155
    Developmental Gene Expression 62
    Gene Ontology 14
    Phenotypes 45
  • Earliest
    J:63705 Tomasetto C, et al., Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology. 2000 Aug;119(2):395-405
  • Latest
    J:227422 Karpova T, et al., Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Biol Reprod. 2015 Oct;93(4):83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory