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Ghrl
Gene Detail
 Symbol
Name
ID
Ghrl
ghrelin
MGI:1930008
Synonyms 2210006E23Rik, Ghr, m46, MTLRP, MTLRPAP
Feature Type protein coding gene
Genetic Map
Chromosome 6
52.84 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:113716119-113719880 bp, - strand
From NCBI annotation of GRCm38

  3762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9487  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: motilin
Gene Tree: Ghrl

Human
homologs
Human Homolog GHRL, ghrelin/obestatin prepropeptide
NCBI Gene ID 51738
neXtProt AC  NX_Q9UBU3
Human Synonyms  MTLRP
Human Chr (Location)  3p26-p25; chr3:10285750-10292947 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GHRL
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for most disruptions in this gene display no phenotypic abnormalities on a regular diet and increased utilization of fat as an energy substrate on a high fat diet. Mice homozygous for one allele display age-dependent changes in stimulated food intake and metabolism.
 
Interactions
Ghrl interacts with 22 markers (Mir20a, Mir96, Mir106b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process actin polymerization or depolymerization, activation of MAPK activity, ...
Component axon, cytoplasm, ...
Function ghrelin receptor binding, G-protein coupled receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (56 records)
Data Summary: Results (111)    Tissues (98)    Images (14)
Theiler Stages: 22, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 95
Northern blot 12
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000064177 (Evidence)
Entrez Gene58991 (Evidence)
UniGene379095
DFCITC1585492, TC1591740, TC1720080
DoTSDT.101158332, DT.103560034, DT.50316838
NIA Mouse Gene IndexU027740
PDB2JSH, 2JSI, 2JSJ
Consensus CDS ProjectCCDS20432.1
International Mouse Knockout Project StatusGhrl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 58991 NCBI Gene Model | MGI Sequence Detail 3762 C57BL/6J ±  kb
transcript NM_021488 RefSeq | MGI Sequence Detail 558 NIH Swiss 
polypeptide Q9EQX0 UniProt | EBI | MGI Sequence Detail 117 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006738 Motilin/ghrelin
InterPro IPR006737 Motilin/ghrelin-associated peptide
InterPro IPR005441 Preproghrelin peptide
Protein Ontology PR:000007973 appetite-regulating hormone
Graphical View of Protein Domain Structure
References (Earliest) J:63705 Tomasetto C, et al., Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology. 2000 Aug;119(2):395-405
(Latest) J:210703 Li E, et al., Ghrelin stimulates proliferation, migration and differentiation of neural progenitors from the subventricular zone in the adult mice. Exp Neurol. 2014 Feb;252:75-84
All references(144)
Other
accession IDs
MGI:1914343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory