Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable ghrelin receptor binding activity; growth hormone-releasing hormone activity; and protein tyrosine kinase activator activity. Involved in adult feeding behavior; positive regulation of appetite; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including excitatory postsynaptic potential; negative regulation of insulin secretion; and positive regulation of synapse assembly. Located in cytoplasm and extracellular region. Is active in neuronal dense core vesicle lumen. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and skeleton. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide).