Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBXW7
  • Mouse genes Fbxw7
  • Rat genes Fbxw7
  • Zfish genes fbxw7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbxw7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030332	cyclin binding	FBXW7	IDA		Human	PMID:12628165
Molecular Function	GO:0030332	cyclin binding	FBXW7	IPI	UniProtKB:P24864	Human	PMID:17434132
Molecular Function	GO:0042802	identical protein binding	FBXW7	IPI	UniProtKB:Q969H0	Human	PMID:21620836
Molecular Function	GO:0042802	identical protein binding	FBXW7	IPI	UniProtKB:Q969H0	Human	PMID:23791182
Molecular Function	GO:0050816	phosphothreonine residue binding	FBXW7	IDA		Human	PMID:17434132
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P63208	Human	PMID:15070733
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P01106	Human	PMID:15103331
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P01106	Human	PMID:17157259
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P01106	Human	PMID:17314511
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P46531	Human	PMID:17909182
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q91LX9	Human	PMID:17909182
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P63208-1	Human	PMID:19412162
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P63208-1	Human	PMID:20596027
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P46531	Human	PMID:20823234
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q13616	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P63208	Human	PMID:21620836
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q9Z0Z7	Human	PMID:22307056
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P46531	Human	PMID:23022380
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q13616	Human	PMID:23108047
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q16204	Human	PMID:23108047
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P01106	Human	PMID:23791182
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P63208	Human	PMID:23791182
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:A1L167	Human	PMID:24000165
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q9H4H8	Human	PMID:24344117
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P46531	Human	PMID:25344755
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P46531	Human	PMID:27229929
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P20393	Human	PMID:27238018
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q3UV55	Human	PMID:27238018
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P05412	Human	PMID:27458189
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q8TB68	Human	PMID:27458189
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P04198	Human	PMID:27837025
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q8WUJ0	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P01106	Human	PMID:28007894
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P63208	Human	PMID:28007894
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q8WUJ0	Human	PMID:28007894
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:Q13616	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P62877,UniProtKB:P63208,UniProtKB:Q04721,UniProtKB:Q13616	Human	PMID:29149593
Molecular Function	GO:0005515	protein binding	FBXW7	IPI	UniProtKB:P01106	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Fbxw7	IPI	UniProtKB:Q61985:PRO_0000076448	Mouse	MGI:MGI:6107392|PMID:21953459
Molecular Function	GO:0005515	protein binding	Fbxw7	IPI	UniProtKB:O60260	Mouse	MGI:MGI:5543313|PMID:23858059
Molecular Function	GO:0005515	protein binding	Fbxw7	IPI	PR:Q61937	Mouse	PMID:18625840
Molecular Function	GO:0005515	protein binding	Fbxw7	IPI	PR:Q01705	Mouse	PMID:11425854
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	FBXW7	IDA		Human	PMID:12628165
Molecular Function	GO:0031625	ubiquitin protein ligase binding	FBXW7	IPI	UniProtKB:O60260	Human	PMID:12628165
Molecular Function	GO:0031625	ubiquitin protein ligase binding	FBXW7	IPI	UniProtKB:Q9WVS6	Human	PMID:12628165
Molecular Function	GO:0097027	ubiquitin-protein transferase activator activity	FBXW7	IDA		Human	PMID:12628165
Cellular Component	GO:0005737	cytoplasm	FBXW7	IDA		Human	PMID:23858059
Cellular Component	GO:0005783	endoplasmic reticulum	Fbxw7	IDA		Mouse	PMID:11735228
Cellular Component	GO:0005794	Golgi apparatus	Fbxw7	IDA		Mouse	PMID:11735228
Cellular Component	GO:0005739	mitochondrion	Fbxw7	IDA		Mouse	MGI:MGI:5543313|PMID:23858059
Cellular Component	GO:0005730	nucleolus	Fbxw7	IDA		Mouse	PMID:18625840
Cellular Component	GO:0005634	nucleus	Fbxw7	IDA		Mouse	MGI:MGI:4887523|PMID:20208556
Cellular Component	GO:0005634	nucleus	Fbxw7	IDA		Mouse	PMID:18625840
Cellular Component	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	FBXW7	IPI	UniProtKB:O60260	Human	PMID:12628165
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Fbxw7	IDA		Mouse	MGI:MGI:4887523|PMID:20208556
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	FBXW7	IDA		Human	PMID:12628165
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	FBXW7	IDA		Human	PMID:15103331
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	FBXW7	IDA		Human	PMID:17434132
Biological Process	GO:0001525	angiogenesis	fbxw7	IMP	ZFIN:ZDB-MRPHLNO-121101-1	Zfish	PMID:22848434
Biological Process	GO:0001525	angiogenesis	fbxw7	IGI	ZFIN:ZDB-MRPHLNO-141105-1,ZFIN:ZDB-MRPHLNO-141105-4	Zfish	PMID:23507969
Biological Process	GO:0001525	angiogenesis	fbxw7	IMP	ZFIN:ZDB-MRPHLNO-141105-1	Zfish	PMID:23507969
Biological Process	GO:0001525	angiogenesis	fbxw7	IMP	ZFIN:ZDB-MRPHLNO-121115-4	Zfish	PMID:22848434
Biological Process	GO:0001525	angiogenesis	fbxw7	IMP	ZFIN:ZDB-MRPHLNO-141105-3	Zfish	PMID:23507969
Biological Process	GO:0030324	lung development	Fbxw7	IMP	MGI:MGI:5007620	Mouse	PMID:21503901
Biological Process	GO:0010629	negative regulation of gene expression	FBXW7	IGI	RNAcentral:URS00001CC379_9606	Human	PMID:23823476
Biological Process	GO:0010629	negative regulation of gene expression	FBXW7	IMP		Human	PMID:23823476
Biological Process	GO:0031642	negative regulation of myelination	fbxw7	IMP	ZFIN:ZDB-GENO-160714-17	Zfish	PMID:26538655
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	fbxw7	IMP	ZFIN:ZDB-GENO-120820-1	Zfish	PMID:22554084
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	fbxw7	IMP	ZFIN:ZDB-MRPHLNO-120814-3	Zfish	PMID:22554084
Biological Process	GO:2001205	negative regulation of osteoclast development	FBXW7	IMP		Human	PMID:29149593
Biological Process	GO:2001205	negative regulation of osteoclast development	Fbxw7	IMP		Mouse	MGI:MGI:6106664|PMID:29149593
Biological Process	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	Fbxw7	IDA		Mouse	PMID:18625840
Biological Process	GO:0007219	Notch signaling pathway	Fbxw7	IDA		Mouse	PMID:11425854
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	FBXW7	IDA		Human	PMID:20208556
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FBXW7	IMP		Human	PMID:20208556
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	FBXW7	IDA		Human	PMID:23858059
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	Fbxw7	IMP		Mouse	MGI:MGI:5543313|PMID:23858059
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	FBXW7	IDA		Human	PMID:23858059
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	Fbxw7	IMP		Mouse	MGI:MGI:5543313|PMID:23858059
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	FBXW7	IMP		Human	PMID:24912190
Biological Process	GO:0031398	positive regulation of protein ubiquitination	FBXW7	IDA		Human	PMID:12628165
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	FBXW7	IDA		Human	PMID:20208556
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	FBXW7	IMP		Human	PMID:27238018
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Fbxw7	IMP		Mouse	MGI:MGI:6282935|PMID:27238018
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	FBXW7	IDA		Human	PMID:12628165
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	FBXW7	IMP		Human	PMID:35395208
Biological Process	GO:0031648	protein destabilization	Fbxw7	IDA		Mouse	PMID:18625840
Biological Process	GO:0050821	protein stabilization	FBXW7	IDA		Human	PMID:20208556
Biological Process	GO:0016567	protein ubiquitination	FBXW7	IDA		Human	PMID:12354302
Biological Process	GO:0016567	protein ubiquitination	FBXW7	IDA		Human	PMID:15103331
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	FBXW7	IMP		Human	PMID:24912190
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	Fbxw7	IMP		Mouse	MGI:MGI:5619435|PMID:23507969
Biological Process	GO:0042752	regulation of circadian rhythm	FBXW7	IMP		Human	PMID:27238018
Biological Process	GO:0042752	regulation of circadian rhythm	Fbxw7	IMP		Mouse	MGI:MGI:6282935|PMID:27238018
Biological Process	GO:0031641	regulation of myelination	fbxw7	IMP	ZFIN:ZDB-GENO-180802-25	Zfish	PMID:28855284
Biological Process	GO:0031641	regulation of myelination	fbxw7	IGI	ZFIN:ZDB-GENO-160715-2	Zfish	PMID:26538655
Biological Process	GO:0031641	regulation of myelination	fbxw7	IMP	ZFIN:ZDB-MRPHLNO-120814-3	Zfish	PMID:28855284
Biological Process	GO:0032006	regulation of TOR signaling	fbxw7	IGI	ZFIN:ZDB-GENO-160715-2	Zfish	PMID:26538655
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	FBXW7	IDA		Human	PMID:15103331
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	FBXW7	IDA		Human	PMID:17434132
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Fbxw7	IDA		Mouse	MGI:MGI:6107392|PMID:21953459
Biological Process	GO:0007062	sister chromatid cohesion	FBXW7	IMP		Human	PMID:15917200
Biological Process	GO:0001570	vasculogenesis	Fbxw7	IMP		Mouse	PMID:21503901

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern