| GO term: | SCF ubiquitin ligase complex |
| Synonym: | CDL1 complex |
| Synonym: | CRL1 complex |
| Synonym: | Cul1-RING ubiquitin ligase complex |
| Synonym: | cullin-RING ligase 1 |
| Synonym: | SCF complex |
| Synonym: | SCF complex substrate recognition subunit |
| Synonym: | Skp1/Cul1/F-box protein complex |
| GO id: | GO:0019005 |
| Definition: | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
| Number of paths to term: | 5 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
cellular_componentcellcell partintracellularintracellular partubiquitin ligase complexcullin-RING ubiquitin ligase complexanaphase-promoting complexCul2-RING ubiquitin ligase complexCul3-RING ubiquitin ligase complexCul4-RING ubiquitin ligase complex +Cul5-RING ubiquitin ligase complexCul7-RING ubiquitin ligase complexCul8-RING ubiquitin ligase complexSCF ubiquitin ligase complex [GO:0019005] (27 genes, 36 annotations)cytoplasmic SCF ubiquitin ligase complexnuclear SCF ubiquitin ligase complexcellular_componentcellcell partintracellular partubiquitin ligase complexcullin-RING ubiquitin ligase complexanaphase-promoting complexCul2-RING ubiquitin ligase complexCul3-RING ubiquitin ligase complexCul4-RING ubiquitin ligase complex +Cul5-RING ubiquitin ligase complexCul7-RING ubiquitin ligase complexCul8-RING ubiquitin ligase complexSCF ubiquitin ligase complex [GO:0019005] (27 genes, 36 annotations)cytoplasmic SCF ubiquitin ligase complexnuclear SCF ubiquitin ligase complexcellular_componentcell partintracellularintracellular partubiquitin ligase complexcullin-RING ubiquitin ligase complexanaphase-promoting complexCul2-RING ubiquitin ligase complexCul3-RING ubiquitin ligase complexCul4-RING ubiquitin ligase complex +Cul5-RING ubiquitin ligase complexCul7-RING ubiquitin ligase complexCul8-RING ubiquitin ligase complexSCF ubiquitin ligase complex [GO:0019005] (27 genes, 36 annotations)cytoplasmic SCF ubiquitin ligase complexnuclear SCF ubiquitin ligase complexcellular_componentcell partintracellular partubiquitin ligase complexcullin-RING ubiquitin ligase complexanaphase-promoting complexCul2-RING ubiquitin ligase complexCul3-RING ubiquitin ligase complexCul4-RING ubiquitin ligase complex +Cul5-RING ubiquitin ligase complexCul7-RING ubiquitin ligase complexCul8-RING ubiquitin ligase complexSCF ubiquitin ligase complex [GO:0019005] (27 genes, 36 annotations)cytoplasmic SCF ubiquitin ligase complexnuclear SCF ubiquitin ligase complexcellular_componentmacromolecular complexprotein complexubiquitin ligase complexcullin-RING ubiquitin ligase complexanaphase-promoting complexCul2-RING ubiquitin ligase complexCul3-RING ubiquitin ligase complexCul4-RING ubiquitin ligase complex +Cul5-RING ubiquitin ligase complexCul7-RING ubiquitin ligase complexCul8-RING ubiquitin ligase complexSCF ubiquitin ligase complex [GO:0019005] (27 genes, 36 annotations)cytoplasmic SCF ubiquitin ligase complexnuclear SCF ubiquitin ligase complexMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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