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Fbxw7
Gene Detail
Symbol

Name
ID
Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695
Synonyms
1110001A17Rik, AGO, Cdc4, Fbw7, Fbxo30, Fbxw6, SEL-10
Feature Type
protein coding gene
Genetic Map
Chromosome 3
37.70 cM, cytoband E3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:84815268-84979198 bp, + strand
From VEGA annotation of GRCm38

  163931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:117451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FBXW7
Gene Tree: Fbxw7

Human
homologs
FBXW7, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55294
neXtProt AC: NX_Q969H0

Human Synonyms: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, hAgo, hCdc4, SEL10, SEL-10

Human Chr (Location): 4q31.3; chr4:152321258-152536095 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(43) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this locus disrupts embryonic and extraembryonic vasculature, resulting in death by midgestation.
 
Phenotype Images(2)
Interactions
Fbxw7 interacts with 408 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cellular response to DNA damage stimulus, cellular response to UV, ...
Component cytoplasm, endoplasmic reticulum, ...
Function cyclin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (24)    Tissues (19)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
RT-PCR 10
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fbxw7 ; ZFIN fbxw7    NEW 
Molecular
reagents
All nucleic(16) Genomic(3) cDNA(12) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000022670 (Evidence)
Ensembl Gene Model ENSMUSG00000028086 (Evidence)
Entrez Gene 50754 (Evidence)
DFCI TC1578883, TC1597594, TC1607571
DoTS DT.101285744, DT.485701, DT.94396701
NIA Mouse Gene Index U003383
Consensus CDS Project CCDS17440.1, CCDS50940.1
International Mouse Phenotyping Consortium Status Fbxw7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022670 VEGA Gene Model | MGI Sequence Detail 163931 C57BL/6J ±  kb
transcript OTTMUST00000054321 VEGA | MGI Sequence Detail 4473 Not Applicable 
polypeptide OTTMUSP00000025916 VEGA | MGI Sequence Detail 710 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(740 from dbSNP Build 137)    SNPs within 2kb including multiple locations(742)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000007427 F-box/WD repeat-containing protein 7
References
(Earliest) J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
(Latest) J:220397 Yumimoto K, et al., F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest. 2015 Feb;125(2):621-35
All references(85)
Other
accession IDs
MGI:1915717

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory