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Fbxw7 Gene Detail
Summary
  • Symbol
    Fbxw7
  • Name
    F-box and WD-40 domain protein 7
  • Synonyms
    1110001A17Rik, AGO, Cdc4, Fbw7, Fbxo30, Fbxw6, SEL-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354695
    NCBI Gene: 50754
  • Gene Overview
    MyGene.info: FBXW7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:84815268-84979198 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      163931 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.70 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, hAgo, hCdc4, SEL10, SEL-10
  • Links
    NCBI Gene ID: 55294
    neXtProt AC: NX_Q969H0
    UniProt: Q969H0

  • Chr Location
    4q31.3; chr4:152321258-152536095 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 117451
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXW7
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    73 phenotypes from 11 alleles in 13 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus disrupts embryonic and extraembryonic vasculature, resulting in death by midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022670 VEGA Gene Model | MGI Sequence Detail 163931 C57BL/6J ±  kb
    transcript OTTMUST00000054321 VEGA | MGI Sequence Detail 4473 Not Applicable  
    polypeptide OTTMUSP00000025916 VEGA | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      721 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 3
      cDNA 12
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915717
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 11
      Phenotypes 47
    • Earliest
      J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
    • Latest
      J:261135 Zhao J, et al., Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A. Diabetes. 2018 May;67(5):818-830

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory