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Fbxw7 Gene Detail
Summary
  • Symbol
    Fbxw7
  • Name
    F-box and WD-40 domain protein 7
  • Synonyms
    1110001A17Rik, AGO, Cdc4, Fbw7, Fbxo30, Fbxw6, SEL-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354695
    NCBI Gene: 50754
  • Gene Overview
    MyGene.info: FBXW7
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:84815268-84979198 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.70 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    721 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354695
protein coding gene Chr3:84812162-84979198 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027347
protein coding gene Chr3:84782040-84952805 (+)
A/J MGP_AJ_G0027311
protein coding gene Chr3:81929393-82095004 (+)
AKR/J MGP_AKRJ_G0027277
protein coding gene Chr3:83871034-84043782 (+)
BALB/cJ MGP_BALBcJ_G0027320
protein coding gene Chr3:82007223-82171623 (+)
C3H/HeJ MGP_C3HHeJ_G0027064
protein coding gene Chr3:84182329-84350313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027766
protein coding gene Chr3:87918639-88093473 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025119
protein coding gene Chr3:77595038-77755817 (+)
CAST/EiJ MGP_CASTEiJ_G0026511
protein coding gene Chr3:84372592-84543353 (+)
CBA/J MGP_CBAJ_G0027039
protein coding gene Chr3:90870153-91059177 (+)
DBA/2J MGP_DBA2J_G0027175
protein coding gene Chr3:81438130-81606644 (+)
FVB/NJ MGP_FVBNJ_G0027143
protein coding gene Chr3:79716381-79884690 (+)
LP/J MGP_LPJ_G0027283
protein coding gene Chr3:85732123-85899662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027162
protein coding gene Chr3:97185188-97360614 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027824
protein coding gene Chr3:83673493-83848852 (+)
PWK/PhJ MGP_PWKPhJ_G0026245
protein coding gene Chr3:81225378-81391536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026061
protein coding gene Chr3:82851590-83021429 (+)
WSB/EiJ MGP_WSBEiJ_G0026589
protein coding gene Chr3:84040917-84211115 (+)



Homology
more
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, hAgo, hCdc4, SEL10, SEL-10
  • Links
    NCBI Gene ID: 55294
    neXtProt AC: NX_Q969H0
    UniProt: Q969H0

  • Chr Location
    4q31.3; chr4:152321258-152536095 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 117451
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXW7
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 11 alleles in 13 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus disrupts embryonic and extraembryonic vasculature, resulting in death by midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028086 Ensembl Gene Model | MGI Sequence Detail 163931 C57BL/6J ±  kb
    transcript ENSMUST00000107678 Ensembl | MGI Sequence Detail 4073 Not Applicable  
    polypeptide ENSMUSP00000103305 Ensembl | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 3
      cDNA 13
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915717
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 13
      Phenotypes 51
    • Earliest
      J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
    • Latest
      J:261891 Sakai E, et al., Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer. Cancer Res. 2018 Mar 1;78(5):1334-1346

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory