About   Help   FAQ
Fbxw7 Gene Detail
Summary
  • Symbol
    Fbxw7
  • Name
    F-box and WD-40 domain protein 7
  • Synonyms
    1110001A17Rik, AGO, Cdc4, Fbw7, Fbxo30, Fbxw6, SEL-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354695
    NCBI Gene: 50754
  • Gene Overview
    MyGene.info: FBXW7
Location & Maps
more
  • Sequence Map
    Chr3:84815268-84979198 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      163931 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.70 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
    Orthology source: HomoloGene
  • Synonyms
    AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, hAgo, hCdc4, SEL10, SEL-10
  • Links
    NCBI Gene ID: 55294
    neXtProt AC: NX_Q969H0

  • Chr Location
    4q31.3; chr4:152321258-152536095 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 117451
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FBXW7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 9 alleles in 11 genetic backgrounds
    10 phenotypes from multigenic genotypes
    2 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    57
  • Chemically induced (other)
    1
  • Gene trapped
    43
  • Radiation induced
    1
  • Targeted
    12
  • Genomic Mutations
    2 involving Fbxw7
  • Incidental Mutations
Homozygous inactivation of this locus disrupts embryonic and extraembryonic vasculature, resulting in death by midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022670 VEGA Gene Model | MGI Sequence Detail 163931 C57BL/6J ±  kb
transcript OTTMUST00000054321 VEGA | MGI Sequence Detail 4473 Not Applicable  
polypeptide OTTMUSP00000025916 VEGA | MGI Sequence Detail 710 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    721 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 3
    cDNA 12
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1915717
References
more
  • Summaries
    All 86
    Developmental Gene Expression 12
    Gene Ontology 9
    Phenotypes 40
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:226332 Maskey D, et al., Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. EMBO J. 2015 Oct 1;34(19):2424-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory