Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRHR2
  • Mouse genes Crhr2
  • Rat genes Crhr2
  • Zfish genes crhr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crhr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	Crhr2	IDA		Mouse	PMID:12032352
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	Crhr2	IDA		Mouse	PMID:15514029
Molecular Function	GO:0043404	corticotropin-releasing hormone receptor activity	Crhr2	IDA		Rat	PMID:12942143|RGD:1358326
Molecular Function	GO:0043404	corticotropin-releasing hormone receptor activity	Crhr2	IDA		Rat	PMID:19334530|RGD:5130955
Molecular Function	GO:0005179	hormone activity	Crhr2	IDA		Mouse	PMID:15514029
Molecular Function	GO:0017046	peptide hormone binding	Crhr2	IPI	RGD:620765	Rat	PMID:19334530|RGD:5130955
Molecular Function	GO:0005515	protein binding	CRHR2	IPI	UniProtKB:Q969E3	Human	PMID:11329063
Molecular Function	GO:0005515	protein binding	CRHR2	IPI	UniProtKB:Q96RP3	Human	PMID:11329063
Molecular Function	GO:0005515	protein binding	Crhr2	IPI	UniProtKB:P55090	Mouse	PMID:15514029
Molecular Function	GO:0005515	protein binding	Crhr2	IPI	PR:Q99ML8	Mouse	PMID:15514029
Cellular Component	GO:0030424	axon	Crhr2	IDA		Rat	PMID:16820012|RGD:5131267
Cellular Component	GO:0043679	axon terminus	Crhr2	IDA		Rat	PMID:21481539|RGD:5490967
Cellular Component	GO:0070852	cell body fiber	Crhr2	IDA		Rat	PMID:21277852|RGD:5491003
Cellular Component	GO:0030425	dendrite	Crhr2	IDA		Rat	PMID:16820012|RGD:5131267
Cellular Component	GO:0005794	Golgi apparatus	Crhr2	IDA		Rat	PMID:16820012|RGD:5131267
Cellular Component	GO:0043025	neuronal cell body	Crhr2	IDA		Rat	PMID:21277852|RGD:5491003
Cellular Component	GO:0043025	neuronal cell body	Crhr2	IDA		Rat	PMID:21481539|RGD:5490967
Cellular Component	GO:0043204	perikaryon	Crhr2	IDA		Rat	PMID:21453754|RGD:5490969
Cellular Component	GO:0005886	plasma membrane	CRHR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Crhr2	IDA		Rat	PMID:20682782|RGD:5491010
Cellular Component	GO:0005791	rough endoplasmic reticulum	Crhr2	IDA		Rat	PMID:16820012|RGD:5131267
Cellular Component	GO:0043196	varicosity	Crhr2	IDA		Rat	PMID:21481539|RGD:5490967
Biological Process	GO:0007015	actin filament organization	Crhr2	IMP		Rat	PMID:17194738|RGD:5131263
Biological Process	GO:0042423	catecholamine biosynthetic process	Crhr2	IMP		Rat	PMID:17194738|RGD:5131263
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Crhr2	IEP		Rat	PMID:21106875|RGD:5130944
Biological Process	GO:0021549	cerebellum development	Crhr2	IEP		Rat	PMID:16820012|RGD:5131267
Biological Process	GO:0030855	epithelial cell differentiation	Crhr2	IMP		Rat	PMID:20551459|RGD:5130947
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Crhr2	IDA		Mouse	PMID:15514029
Biological Process	GO:0035482	gastric motility	Crhr2	IMP		Rat	PMID:16012930|RGD:5131268
Biological Process	GO:0021854	hypothalamus development	Crhr2	IEP		Rat	PMID:20002962|RGD:5130950
Biological Process	GO:0060291	long-term synaptic potentiation	Crhr2	IMP		Rat	PMID:17004937|RGD:5131266
Biological Process	GO:0060291	long-term synaptic potentiation	Crhr2	IMP		Rat	PMID:19376201|RGD:5130954
Biological Process	GO:0016525	negative regulation of angiogenesis	Crhr2	IMP	MGI:MGI:2178545	Mouse	PMID:12032352
Biological Process	GO:0090281	negative regulation of calcium ion import	Crhr2	IMP		Rat	PMID:19439178|RGD:5130951
Biological Process	GO:2000293	negative regulation of defecation	Crhr2	IMP		Rat	PMID:21277852|RGD:5491003
Biological Process	GO:0032811	negative regulation of epinephrine secretion	Crhr2	IMP		Rat	PMID:17194738|RGD:5131263
Biological Process	GO:2000252	negative regulation of feeding behavior	Crhr2	IDA		Rat	PMID:17050037|RGD:5131264
Biological Process	GO:0046882	negative regulation of follicle-stimulating hormone secretion	Crhr2	IMP		Rat	PMID:19193717|RGD:2317015
Biological Process	GO:0010629	negative regulation of gene expression	Crhr2	IMP		Rat	PMID:19193717|RGD:2317015
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Crhr2	IMP		Rat	PMID:17360501|RGD:2306172
Biological Process	GO:0033685	negative regulation of luteinizing hormone secretion	Crhr2	IMP		Rat	PMID:19193717|RGD:2317015
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	Crhr2	IMP		Rat	PMID:17194738|RGD:5131263
Biological Process	GO:0045777	positive regulation of blood pressure	Crhr2	IMP		Rat	PMID:20060787|RGD:5130949
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Crhr2	IMP		Rat	PMID:16005543|RGD:5131269
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Crhr2	IDA		Rat	PMID:20682782|RGD:5491010
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Crhr2	IDA		Rat	PMID:21277852|RGD:5491003
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	Crhr2	IMP		Rat	PMID:16005543|RGD:5131269
Biological Process	GO:0010628	positive regulation of gene expression	Crhr2	IMP		Rat	PMID:19193717|RGD:2317015
Biological Process	GO:0010460	positive regulation of heart rate	Crhr2	IMP		Rat	PMID:20060787|RGD:5130949
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Crhr2	IMP		Rat	PMID:19211730|RGD:5130956
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Crhr2	IMP		Rat	PMID:19211730|RGD:5130956
Biological Process	GO:0014064	positive regulation of serotonin secretion	Crhr2	IMP		Rat	PMID:20655906|RGD:5130946
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Crhr2	IMP		Rat	PMID:19211730|RGD:5130956
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Crhr2	IMP		Rat	PMID:19439178|RGD:5130951
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Crhr2	IMP		Rat	PMID:21277852|RGD:5491003
Biological Process	GO:0019233	sensory perception of pain	Crhr2	IMP		Rat	PMID:19065825|RGD:5131254
Biological Process	GO:0048630	skeletal muscle tissue growth	Crhr2	IDA		Rat	PMID:21235761|RGD:5130936

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern