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Crhr2
Gene Detail
Symbol

Name
ID
Crhr2
corticotropin releasing hormone receptor 2
MGI:894312
Synonyms
CRF 2 receptor, Crfr2, CRF-R2, CRFR2alpha, CRFR2beta, CRH-R2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:55090049-55133016 bp, - strand
From VEGA annotation of GRCm38

  42968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRHR2
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Crhr2

Human
homologs
CRHR2, corticotropin releasing hormone receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1395
neXtProt AC: NX_Q13324

Human Synonyms: CRF2, CRFR2, CRF-RB, HM-CRF

Human Chr (Location): 7p14.3; chr7:30651843-30700103 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene may result in hypersensitivity to stress, increased anxiety-like behavior, abnormal homeostatic responses to challenges of increased dietary fat and cold, and cardiovascular abnormalities, including hypertension and decreased cardiac contractility.
 
Interactions
Crhr2 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (130)    Tissues (63)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 50
RT-PCR 80
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase crhr2    NEW 
Molecular
reagents
All nucleic(22) Genomic(4) cDNA(11) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035963 (Evidence)
Ensembl Gene Model ENSMUSG00000003476 (Evidence)
Entrez Gene 12922 (Evidence)
UniGene 236081
DFCI TC1588074, TC1592638
DoTS DT.110500434, DT.40175756, DT.55255294
NIA Mouse Gene Index U027347
PDB 1U34, 2JNC, 2JND
Consensus CDS Project CCDS20162.1
International Mouse Phenotyping Consortium Status Crhr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035963 VEGA Gene Model | MGI Sequence Detail 42968 C57BL/6J ±  kb
transcript OTTMUST00000092261 VEGA | MGI Sequence Detail 2695 Not Applicable 
polypeptide OTTMUSP00000050946 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(10) UniProt(6)
Polymorphisms
PCR(2) : SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003051 GPCR, family 2, corticotropin releasing factor receptor
InterPro IPR003053 GPCR, family 2, corticotropin releasing factor receptor, type 2
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000005870 corticotropin-releasing factor receptor 2
References
(Earliest) J:24160 Perrin M, et al., Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2969-73
(Latest) J:205938 Zorrilla EP, et al., Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. PLoS One. 2013;8(8):e63942
All references(81)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory