Crhr2
Gene Detail

Symbol Name ID

Crhr2 corticotropin releasing hormone receptor 2 MGI:894312

Synonyms

CRF 2 receptor, Crfr2, CRF-R2, CRFR2alpha, CRFR2beta, CRH-R2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

27.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:55090049-55133016 bp, - strand From VEGA annotation of GRCm38   42968 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Crhr2

Human homologs

Human Homolog		CRHR2, corticotropin releasing hormone receptor 2
NCBI Gene ID		1395
neXtProt AC		NX_Q13324
Human Synonyms		CRF2, CRFR2, CRF-RB, HM-CRF
Human Chr (Location)		7p14.3; chr7:30691559-30739719 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous inactivation of this gene may result in hypersensitivity to stress, increased anxiety-like behavior, abnormal homeostatic responses to challenges of increased dietary fat and cold, and cardiovascular abnormalities, including hypertension and decreased cardiac contractility.

 

Gene Ontology (GO) classifications

All GO classifications: (63 annotations)

Process	actin filament organization, catecholamine biosynthetic process, ...
Component	axon, axon terminus, ...
Function	corticotrophin-releasing factor receptor activity, corticotropin-releasing hormone receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (130)    Tissues (62)    Images (13)
Theiler Stages: 19, 20, 23, 26, 28

Assay Type	Results
RNA in situ	50
RT-PCR	80

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(4) cDNA(11) Primer pair(7)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000035963 (Evidence)
Ensembl Gene Model	ENSMUSG00000003476 (Evidence)
Entrez Gene	12922 (Evidence)
UniGene	236081
DFCI	TC1588074, TC1592638
DoTS	DT.110500434, DT.40175756, DT.55255294
NIA Mouse Gene Index	U027347
PDB	2JNC, 2JND, 1U34
Consensus CDS Project	CCDS20162.1
International Mouse Knockout Project Status	Crhr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035963	VEGA Gene Model | MGI Sequence Detail	42968	C57BL/6J
transcript	OTTMUST00000092261	VEGA | MGI Sequence Detail	2695	Not Applicable
polypeptide	OTTMUSP00000050946	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(48) RefSeq(2) UniProt(7)

Polymorphisms

PCR(2) : SNPs(303 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003051	GPCR, family 2, corticotropin releasing factor receptor
InterPro	IPR003053	GPCR, family 2, corticotropin releasing factor receptor, type 2
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000005870	corticotropin-releasing factor receptor 2

References

(Earliest) J:24160 Perrin M, et al., Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2969-73
(Latest) J:191829 Gerber AR, et al., Antiinflammatory treatment ameliorates HPA stress axis dysfunction in a mouse model of stress sensitivity. Endocrinology. 2012 Oct;153(10):4830-7
All references(80)