Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Clu

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CLU
- Mouse genes Clu
- Rat genes Clu
- Zfish genes clu
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clu

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	CLU	IDA		Human	PMID:22179788
Molecular Function	GO:0001540	amyloid-beta binding	CLU	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:23106396
Molecular Function	GO:0001540	amyloid-beta binding	CLU	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:9228033
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	CLU	IPI	UniProtKB:C0HL13	Human	PMID:9228033
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	CLU	IPI	UniProtKB:P98164	Human	PMID:9228033
Molecular Function	GO:0051787	misfolded protein binding	CLU	IDA		Human	PMID:11123922
Molecular Function	GO:0051787	misfolded protein binding	CLU	IPI	UniProtKB:P00450	Human	PMID:19996109
Molecular Function	GO:0051787	misfolded protein binding	CLU	IPI	UniProtKB:P02675	Human	PMID:19996109
Molecular Function	GO:0051787	misfolded protein binding	CLU	IPI	UniProtKB:P02768	Human	PMID:19996109
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:Q07812	Human	PMID:16113678
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:Q9NRI5	Human	PMID:17043677
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P30101	Human	PMID:17170699
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:O95925	Human	PMID:17567961
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P01100	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P37231	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:22179788
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:22528093
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P11021	Human	PMID:22689054
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:O00499	Human	PMID:25051234
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P18509	Human	PMID:25451228
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P30101	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P37840	Human	PMID:28887769
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P37840	Human	PMID:31270237
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:P37173	Human	PMID:8555189
Molecular Function	GO:0005515	protein binding	CLU	IPI	UniProtKB:Q04771	Human	PMID:8555189
Molecular Function	GO:0005515	protein binding	Clu	IPI	UniProtKB:P23475	Mouse	MGI:MGI:2653704\|PMID:12551933
Molecular Function	GO:0005515	protein binding	Clu	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Clu	IPI	UniProtKB:B0R5N9	Rat	PMID:11570883\|RGD:12792997
Molecular Function	GO:0005515	protein binding	Clu	IPI	RGD:1560377	Rat	PMID:16038898\|RGD:1582420
Molecular Function	GO:0005515	protein binding	Clu	IPI	RGD:3628	Rat	PMID:16038898\|RGD:1582420
Molecular Function	GO:0005515	protein binding	Clu	IPI	RGD:621532	Rat	PMID:16038898\|RGD:1582420
Molecular Function	GO:0005515	protein binding	Clu	IPI	RGD:737331	Rat	PMID:19664600\|RGD:9068416
Molecular Function	GO:0140597	protein carrier chaperone	CLU	IDA		Human	PMID:9228033
Molecular Function	GO:0044877	protein-containing complex binding	CLU	IPI	ComplexPortal:CPX-1180	Human	PMID:22179788
Molecular Function	GO:0044877	protein-containing complex binding	CLU	IPI	ComplexPortal:CPX-1180\|UniProtKB:P05067:PRO_0000000093	Human	PMID:23106396
Molecular Function	GO:0005102	signaling receptor binding	CLU	IPI	UniProtKB:Q9NZC2	Human	PMID:27477018
Molecular Function	GO:0048156	tau protein binding	CLU	IPI	UniProtKB:P10636	Human	PMID:25051234
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CLU	IDA		Human	PMID:20068069
Molecular Function	GO:0051082	unfolded protein binding	CLU	IMP		Human	PMID:25402950
Cellular Component	GO:0016235	aggresome	Clu	IDA		Rat	PMID:12799419\|RGD:1582417
Cellular Component	GO:0097440	apical dendrite	CLU	IDA		Human	PMID:9560017
Cellular Component	GO:0072562	blood microparticle	CLU	HDA		Human	PMID:22516433
Cellular Component	GO:0071944	cell periphery	CLU	IDA		Human	PMID:21803450
Cellular Component	GO:0009986	cell surface	CLU	IDA		Human	PMID:17567961
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CLU	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CLU	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CLU	HDA		Human	PMID:27559042
Cellular Component	GO:0005737	cytoplasm	CLU	IDA		Human	PMID:17689225
Cellular Component	GO:0005737	cytoplasm	CLU	IDA		Human	PMID:22689054
Cellular Component	GO:0005737	cytoplasm	CLU	IDA		Human	PMID:25051234
Cellular Component	GO:0005737	cytoplasm	CLU	IDA		Human	PMID:9560017
Cellular Component	GO:0005737	cytoplasm	Clu	IDA		Mouse	MGI:MGI:2653704\|PMID:12551933
Cellular Component	GO:0005737	cytoplasm	Clu	IDA		Rat	PMID:21762182\|RGD:9068406
Cellular Component	GO:0005856	cytoskeleton	CLU	IDA		Human	PMID:25051234
Cellular Component	GO:0005829	cytosol	CLU	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CLU	IDA		Human	PMID:22689054
Cellular Component	GO:0005829	cytosol	Clu	IDA		Mouse	MGI:MGI:6304543\|PMID:22197644
Cellular Component	GO:0005829	cytosol	Clu	IDA		Rat	PMID:16038898\|RGD:1582420
Cellular Component	GO:0070062	extracellular exosome	CLU	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CLU	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CLU	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	CLU	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	CLU	IDA		Human	PMID:11123922
Cellular Component	GO:0005615	extracellular space	CLU	IDA		Human	PMID:16113678
Cellular Component	GO:0005615	extracellular space	CLU	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	CLU	IDA		Human	PMID:17567961
Cellular Component	GO:0005615	extracellular space	CLU	IDA		Human	PMID:19996109
Cellular Component	GO:0005615	extracellular space	CLU	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Clu	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Clu	IDA		Rat	PMID:11570883\|RGD:12792997
Cellular Component	GO:0005615	extracellular space	Clu	IDA		Rat	PMID:22581811\|RGD:7245501
Cellular Component	GO:0030426	growth cone	Clu	IDA		Rat	PMID:16038898\|RGD:1582420
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CLU	IDA		Human	PMID:22689054
Cellular Component	GO:0016020	membrane	CLU	IDA		Human	PMID:25051234
Cellular Component	GO:0005743	mitochondrial inner membrane	CLU	IDA		Human	PMID:17689225
Cellular Component	GO:0005739	mitochondrion	CLU	IDA		Human	PMID:16113678
Cellular Component	GO:0005739	mitochondrion	CLU	IDA		Human	PMID:22689054
Cellular Component	GO:0005739	mitochondrion	Clu	IDA		Mouse	MGI:MGI:6304543\|PMID:22197644
Cellular Component	GO:0097418	neurofibrillary tangle	CLU	IDA		Human	PMID:15897157
Cellular Component	GO:0097418	neurofibrillary tangle	CLU	IDA		Human	PMID:9560017
Cellular Component	GO:0043005	neuron projection	Clu	IDA		Rat	PMID:16038898\|RGD:1582420
Cellular Component	GO:0005634	nucleus	CLU	IDA		Human	PMID:19137541
Cellular Component	GO:0005634	nucleus	CLU	IDA		Human	PMID:25051234
Cellular Component	GO:0005634	nucleus	Clu	IDA		Mouse	MGI:MGI:2653704\|PMID:12551933
Cellular Component	GO:0005634	nucleus	Clu	IDA		Rat	PMID:21762182\|RGD:9068406
Cellular Component	GO:0099020	perinuclear endoplasmic reticulum lumen	CLU	IDA		Human	PMID:22689054
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CLU	IDA		Human	PMID:20068069
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Clu	IDA		Rat	PMID:16038898\|RGD:1582420
Cellular Component	GO:0032991	protein-containing complex	CLU	IDA		Human	PMID:17567961
Cellular Component	GO:0032991	protein-containing complex	CLU	IDA		Human	PMID:9228033
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	CLU	IDA		Human	PMID:16682745
Cellular Component	GO:0045202	synapse	Clu	IDA		Mouse	PMID:16452087
Cellular Component	GO:0045202	synapse	Clu	EXP		Mouse	PMID:16452087
Biological Process	GO:0007568	aging	Clu	IEP		Rat	PMID:18546156\|RGD:9068430
Biological Process	GO:0000902	cell morphogenesis	CLU	IDA		Human	PMID:15857407
Biological Process	GO:0071363	cellular response to growth factor stimulus	Clu	IEP		Rat	PMID:16038898\|RGD:1582420
Biological Process	GO:0032286	central nervous system myelin maintenance	CLU	IMP		Human	PMID:21543606
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	CLU	IDA		Human	PMID:17412999
Biological Process	GO:0061077	chaperone-mediated protein folding	CLU	IDA		Human	PMID:11123922
Biological Process	GO:0031018	endocrine pancreas development	Clu	IMP		Rat	PMID:16411126\|RGD:1582421
Biological Process	GO:0044849	estrous cycle	Clu	IEP		Rat	PMID:11149574\|RGD:9068389
Biological Process	GO:0002434	immune complex clearance	Clu	IMP		Mouse	MGI:MGI:2159518\|PMID:11865066
Biological Process	GO:0001774	microglial cell activation	CLU	IDA		Human	PMID:15857407
Biological Process	GO:0061518	microglial cell proliferation	CLU	IDA		Human	PMID:15857407
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	CLU	IDA		Human	PMID:22179788
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	Clu	IMP		Mouse	MGI:MGI:3621689\|PMID:14741101
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	CLU	IDA		Human	PMID:12047389
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	CLU	IDA		Human	PMID:17412999
Biological Process	GO:0043066	negative regulation of apoptotic process	Clu	IMP		Rat	PMID:15591223\|RGD:1582419
Biological Process	GO:0060548	negative regulation of cell death	CLU	IMP		Human	PMID:21803450
Biological Process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	CLU	IMP		Human	PMID:16113678
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	CLU	IMP		Human	PMID:16113678
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	CLU	IDA		Human	PMID:22179788
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	CLU	IDA		Human	PMID:23106396
Biological Process	GO:1903573	negative regulation of response to endoplasmic reticulum stress	CLU	IMP		Human	PMID:21803450
Biological Process	GO:0048812	neuron projection morphogenesis	Clu	IMP		Rat	PMID:16038898\|RGD:1582420
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	Clu	IMP		Mouse	MGI:MGI:2384259\|PMID:12145324
Biological Process	GO:0043065	positive regulation of apoptotic process	Clu	IDA		Mouse	MGI:MGI:2653704\|PMID:12551933
Biological Process	GO:0045597	positive regulation of cell differentiation	Clu	IMP		Rat	PMID:16411126\|RGD:1582421
Biological Process	GO:0008284	positive regulation of cell population proliferation	Clu	IMP		Rat	PMID:15591223\|RGD:1582419
Biological Process	GO:0010628	positive regulation of gene expression	Clu	IGI	ComplexPortal:CPX-1120\|ComplexPortal:CPX-1134\|UniProtKB:P05067:PRO_0000000092\|UniProtKB:P05067:PRO_0000000093	Rat	PMID:23164821\|RGD:12903240
Biological Process	GO:1902998	positive regulation of neurofibrillary tangle assembly	CLU	IMP		Human	PMID:15897157
Biological Process	GO:1901216	positive regulation of neuron death	CLU	IDA		Human	PMID:15857407
Biological Process	GO:1901216	positive regulation of neuron death	CLU	IMP		Human	PMID:15897157
Biological Process	GO:1901216	positive regulation of neuron death	Clu	IMP		Mouse	MGI:MGI:2384259\|PMID:12145324
Biological Process	GO:1901216	positive regulation of neuron death	Clu	IGI	ComplexPortal:CPX-1120\|ComplexPortal:CPX-1134\|UniProtKB:P05067:PRO_0000000092\|UniProtKB:P05067:PRO_0000000093	Rat	PMID:23164821\|RGD:12903240
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	CLU	IMP		Human	PMID:20068069
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	CLU	IDA		Human	PMID:15857407
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	CLU	IMP		Human	PMID:20068069
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	CLU	IDA		Human	PMID:22179788
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	CLU	IGI	UniProtKB:C0HL13	Human	PMID:9228033
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	CLU	IMP		Human	PMID:15897157
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	CLU	IDA		Human	PMID:15857407
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	CLU	IMP		Human	PMID:20068069
Biological Process	GO:0017038	protein import	CLU	IDA		Human	PMID:24446231
Biological Process	GO:0050821	protein stabilization	CLU	IDA		Human	PMID:11123922
Biological Process	GO:0050821	protein stabilization	CLU	IDA		Human	PMID:12176985
Biological Process	GO:0050821	protein stabilization	Clu	IDA		Rat	PMID:11570883\|RGD:12792997
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	CLU	IDA		Human	PMID:9228033
Biological Process	GO:1900221	regulation of amyloid-beta clearance	CLU	IDA		Human	PMID:24446231
Biological Process	GO:0042127	regulation of cell population proliferation	CLU	IMP		Human	PMID:19137541
Biological Process	GO:0043523	regulation of neuron apoptotic process	clu	IMP	ZFIN:ZDB-MRPHLNO-151109-10	Zfish	PMID:25434681
Biological Process	GO:1901214	regulation of neuron death	CLU	IDA		Human	PMID:17412999
Biological Process	GO:1901214	regulation of neuron death	CLU	IMP		Human	PMID:9560017
Biological Process	GO:1902847	regulation of neuronal signal transduction	CLU	IMP		Human	PMID:21397462
Biological Process	GO:0009416	response to light stimulus	Clu	IEP		Rat	PMID:11803476\|RGD:9062370
Biological Process	GO:0051788	response to misfolded protein	CLU	IDA		Human	PMID:19996109
Biological Process	GO:0035864	response to potassium ion	Clu	IEP		Rat	PMID:12782389\|RGD:727237
Biological Process	GO:0009615	response to virus	CLU	IEP		Human	PMID:16548883
Biological Process	GO:0009611	response to wounding	Clu	IEP		Rat	PMID:12457227\|RGD:1582400

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.