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Clu
Gene Detail
 Symbol
Name
ID
Clu
clusterin
MGI:88423
Synonyms ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp2, Sgp-2, SP-40, Sugp-2, testosterone repressed prostate message-2
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr14:65968483-65981548 bp, + strand
From VEGA annotation of GRCm38

  13066 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: clusterin
Gene Tree: Clu

Human
homologs
Human Homolog CLU, clusterin
NCBI Gene ID 1191
neXtProt AC  NX_P10909
Human Synonyms  APOJ, APO-J, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP2, SGP-2, SP-40, TRPM2, TRPM-2
Human Chr (Location)  8p21-p12; chr8:27596917-27615031 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous inactivation of this gene leads to progressive renal glomerulopathy and increased severity of myosin-induced autoimmune myocarditis.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Clu interacts with 51 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process cell death, cell morphogenesis, ...
Component aggresome, apical dendrite, ...
Function misfolded protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (269)    Tissues (242)    Images (53)
Theiler Stages: 12, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 246
RT-PCR 23
cDNA source data(575)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(591) Genomic(4) cDNA(578) Primer pair(7) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000032654 (Evidence)
Ensembl Gene ModelENSMUSG00000022037 (Evidence)
Entrez Gene12759 (Evidence)
UniGene200608
DFCITC1573780, TC1661408, TC1735252
DoTSDT.101190629, DT.101316252, DT.101316259, DT.101713458, DT.91337342, DT.94226792
NIA Mouse Gene IndexU015783
Consensus CDS ProjectCCDS36957.1
International Mouse Knockout Project StatusClu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032654 VEGA Gene Model | MGI Sequence Detail 13066 C57BL/6J ±  kb
transcript OTTMUST00000081231 VEGA | MGI Sequence Detail 1811 Not Applicable 
polypeptide OTTMUSP00000043417 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(6) UniProt(10)
Polymorphisms RFLP(4) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016016 Clusterin
InterPro IPR016015 Clusterin, C-terminal
InterPro IPR000753 Clusterin-like
InterPro IPR016014 Clusterin, N-terminal
Protein Ontology PR:000005615 clusterin
References (Earliest) J:17167 Jenne DE, et al., Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7123-7
(Latest) J:208329 Nguan CY, et al., Promotion of cell proliferation by clusterin in the renal tissue repair phase after ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2014 Apr;306(7):F724-33
All references(133)
Other
accession IDs
MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory