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Clu Gene Detail
Summary
  • Symbol
    Clu
  • Name
    clusterin
  • Synonyms
    ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp2, Sgp-2, SP-40, Sugp-2, testosterone repressed prostate message-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88423
    NCBI Gene: 12759
  • Gene Overview
    MyGene.info: CLU
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:65968483-65981547 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88423
 protein coding gene Chr14:65968483-65981548 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021488
 protein coding gene Chr14:60610719-60623779 (+)
A/J MGP_AJ_G0021447
 protein coding gene Chr14:59192551-59205610 (+)
AKR/J MGP_AKRJ_G0021423
 protein coding gene Chr14:61245352-61258411 (+)
BALB/cJ MGP_BALBcJ_G0021453
 protein coding gene Chr14:59134321-59147380 (+)
C3H/HeJ MGP_C3HHeJ_G0021230
 protein coding gene Chr14:60922990-60938591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021892
 protein coding gene Chr14:63403013-63416071 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019432
 protein coding gene Chr14:57112529-57125546 (+)
CAST/EiJ MGP_CASTEiJ_G0020747
 protein coding gene Chr14:57401272-57415815 (+)
CBA/J MGP_CBAJ_G0021197
 protein coding gene Chr14:65319887-65332964 (+)
DBA/2J MGP_DBA2J_G0021320
 protein coding gene Chr14:58839524-58852580 (+)
FVB/NJ MGP_FVBNJ_G0021299
 protein coding gene Chr14:58249960-58263018 (+)
LP/J MGP_LPJ_G0021395
 protein coding gene Chr14:61650603-61665487 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021328
 protein coding gene Chr14:64396226-64412210 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021915
 protein coding gene Chr14:60446198-60459256 (+)
PWK/PhJ MGP_PWKPhJ_G0020491
 protein coding gene Chr14:55567043-55580304 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020324
 protein coding gene Chr14:56414688-56429135 (+)
WSB/EiJ MGP_WSBEiJ_G0020800
 protein coding gene Chr14:60738247-60753374 (+)



Homology
more
  • Human Ortholog
    CLU, clusterin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLU, clusterin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAG4, APOJ, APO-J, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP2, SGP-2, SP-40, TRPM2, TRPM-2
  • Links
    NCBI Gene ID: 1191
    neXtProt AC: NX_P10909
    UniProt: P10909

  • Chr Location
    8p21.1; chr8:27596917-27616717 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 1382
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLU
  • Protein SuperFamily
    clusterin
  • Gene Tree
    Clu
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to progressive renal glomerulopathy and increased severity of myosin-induced autoimmune myocarditis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    989
  • Tissues
    280
  • cDNA Data
    576
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022037 Ensembl Gene Model | MGI Sequence Detail 13065 C57BL/6J ±  kb
    transcript ENSMUST00000022616 Ensembl | MGI Sequence Detail 1810 Not Applicable  
    polypeptide ENSMUSP00000022616 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 592
      Genomic 4
      cDNA 578
      Primer pair 9
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 45
      Diseases 2
      Gene Ontology 12
      Phenotypes 47
    • Earliest
      J:17167 Jenne DE, et al., Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7123-7
    • Latest
      J:299018 Park JS, et al., Clusterin overexpression protects against western diet-induced obesity and NAFLD. Sci Rep. 2020 Oct 15;10(1):17484
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/19/2021
    MGI 6.16     		The Jackson Laboratory