Clu
Gene Detail

Symbol Name ID

Clu clusterin MGI:88423

Synonyms

ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp2, Sgp-2, SP-40, Sugp-2, testosterone repressed prostate message-2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr14:65968483-65981548 bp, + strand From VEGA annotation of GRCm38   13066 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Clu ± 2 cM)

Protein SuperFamily: clusterin
Gene Tree: Clu

Human ortholog

CLU clusterin NCBI Gene ID 1191
Human Synonyms: APOJ, APO-J, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP2, SGP-2, SP-40, TRPM2, TRPM-2
Human Chr8:27454451-27472327 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous inactivation of this gene leads to progressive renal glomerulopathy and increased severity of myosin-induced autoimmune myocarditis.

 
Human Diseases Modeled Using Mouse Clu (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	cell death, chaperone-mediated protein folding, ...
Component	aggresome, cytoplasm, ...
Function	misfolded protein binding, ubiquitin protein ligase binding

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (209)    Tissues (179)    Images (51)
Theiler Stages: 12, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	186
RT-PCR	23

cDNA source data(573)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(589) Genomic(4) cDNA(576) Primer pair(7) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000032654 (Evidence)
Ensembl Gene Model	ENSMUSG00000022037 (Evidence)
Entrez Gene	12759 (Evidence)
UniGene	200608
DFCI	TC1573780, TC1661408, TC1735252
DoTS	DT.101190629, DT.101316252, DT.101316259, DT.101713458, DT.91337342, DT.94226792
NIA Mouse Gene Index	U015783
Consensus CDS Project	CCDS36957.1
International Mouse Knockout Project Status	Clu

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032654	VEGA Gene Model | MGI Sequence Detail	13066	C57BL/6J
transcript	OTTMUST00000081231	VEGA | MGI Sequence Detail	1811	Not Applicable
polypeptide	OTTMUSP00000043417	VEGA | MGI Sequence Detail	448	Not Applicable

All sequences(76) RefSeq(2) UniProt(10)

Polymorphisms

RFLP(4) : SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016016	Clusterin
InterPro	IPR016015	Clusterin, C-terminal
InterPro	IPR000753	Clusterin-like
InterPro	IPR016014	Clusterin, N-terminal
Protein Ontology	PR:000005615	clusterin

References

(Earliest) J:17167 Jenne DE, et al., Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7123-7
(Latest) J:188148 Landin MA, et al., Gene Expression Profiling during Murine Tooth Development. Front Genet. 2012;3:139
All references(123)

Other accession IDs

MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170