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Clu Gene Detail
Summary
  • Symbol
    Clu
  • Name
    clusterin
  • Synonyms
    ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp2, Sgp-2, SP-40, Sugp-2, testosterone repressed prostate message-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88423
    NCBI Gene: 12759
  • Gene Overview
    MyGene.info: CLU
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr14:65968483-65981548 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13066 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    CLU, clusterin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLU, clusterin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAG4, APOJ, APO-J, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP2, SGP-2, SP-40, TRPM2, TRPM-2
  • Links
    NCBI Gene ID: 1191
    neXtProt AC: NX_P10909
    UniProt: P10909

  • Chr Location
    8p21.1; chr8:27596917-27616717 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 1382
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLU
  • Protein SuperFamily
    clusterin
  • Gene Tree
    Clu
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to progressive renal glomerulopathy and increased severity of myosin-induced autoimmune myocarditis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    269
  • Tissues
    242
  • cDNA Data
    575
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032654 VEGA Gene Model | MGI Sequence Detail 13066 C57BL/6J ±  kb
    transcript OTTMUST00000081231 VEGA | MGI Sequence Detail 1811 Not Applicable  
    polypeptide OTTMUSP00000043417 VEGA | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      41 from dbSNP Build 142
    • RFLP
      4
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 590
      Genomic 4
      cDNA 577
      Primer pair 7
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 37
      Diseases 2
      Gene Ontology 6
      Phenotypes 41
    • Earliest
      J:17167 Jenne DE, et al., Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7123-7
    • Latest
      J:259186 Heng X, et al., Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory