Clu
Gene Detail

Symbol Name ID

Clu clusterin MGI:88423

Synonyms

ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp2, Sgp-2, SP-40, Sugp-2, testosterone repressed prostate message-2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr14:65968483-65981548 bp, + strand From VEGA annotation of GRCm38   13066 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: clusterin
Gene Tree: Clu

Human homologs

Human Homolog		CLU, clusterin
NCBI Gene ID		1191
neXtProt AC		NX_P10909
Human Synonyms		APOJ, APO-J, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP2, SGP-2, SP-40, TRPM2, TRPM-2
Human Chr (Location)		8p21-p12; chr8:27596917-27615031 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from APF )
 

Homozygous inactivation of this gene leads to progressive renal glomerulopathy and increased severity of myosin-induced autoimmune myocarditis.

 
Alleles Annotated to Human Diseases(1)   

Interactions

Clu interacts with 51 markers (Mir9-1, Mir9-2, Mir9-3, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	cell death, cell morphogenesis, ...
Component	aggresome, apical dendrite, ...
Function	misfolded protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)

Data Summary: Results (269)    Tissues (239)    Images (53)
Theiler Stages: 12, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	246
RT-PCR	23

cDNA source data(575)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular reagents

All nucleic(591) Genomic(4) cDNA(578) Primer pair(7) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000032654 (Evidence)
Ensembl Gene Model	ENSMUSG00000022037 (Evidence)
Entrez Gene	12759 (Evidence)
UniGene	200608
DFCI	TC1573780, TC1661408, TC1735252
DoTS	DT.101190629, DT.101316252, DT.101316259, DT.101713458, DT.91337342, DT.94226792
NIA Mouse Gene Index	U015783
Consensus CDS Project	CCDS36957.1
International Mouse Knockout Project Status	Clu

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032654	VEGA Gene Model | MGI Sequence Detail	13066	C57BL/6J
transcript	OTTMUST00000081231	VEGA | MGI Sequence Detail	1811	Not Applicable
polypeptide	OTTMUSP00000043417	VEGA | MGI Sequence Detail	448	Not Applicable

All sequences(80) RefSeq(6) UniProt(10)

Polymorphisms

RFLP(4) : SNPs within 2kb(41 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR016016	Clusterin
InterPro	IPR016015	Clusterin, C-terminal
InterPro	IPR000753	Clusterin-like
InterPro	IPR016014	Clusterin, N-terminal
Protein Ontology	PR:000005615	clusterin

References

(Earliest) J:17167 Jenne DE, et al., Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7123-7
(Latest) J:208329 Nguan CY, et al., Promotion of cell proliferation by clusterin in the renal tissue repair phase after ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2014 Apr;306(7):F724-33
All references(134)

Other accession IDs

MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170