Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Clock

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CLOCK
- Mouse genes Clock
- Rat genes Clock
- Zfish genes clocka,clockb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clock

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	Clock	IDA		Mouse	MGI:MGI:5568183\|PMID:24610784
Molecular Function	GO:0003677	DNA binding	CLOCK	IDA		Human	PMID:11441146
Molecular Function	GO:0003677	DNA binding	clocka	IDA		Zfish	PMID:15591021
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Clock	IDA		Mouse	MGI:MGI:5306311\|PMID:15560782
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Clock	IDA		Mouse	MGI:MGI:5442460\|PMID:22653727
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Clock	IDA		Mouse	PMID:12024206
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Clock	IDA		Mouse	MGI:MGI:5297789\|PMID:15147242
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	clocka	IDA		Zfish	ZFIN:ZDB-PUB-170709-3
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	clocka	IDA		Zfish	PMID:28687631
Molecular Function	GO:0070888	E-box binding	CLOCK	IDA		Human	PMID:18411297
Molecular Function	GO:0070888	E-box binding	CLOCK	IDA		Human	PMID:23785138
Molecular Function	GO:0070888	E-box binding	Clock	IDA		Mouse	MGI:MGI:4837055\|PMID:20430893
Molecular Function	GO:0070888	E-box binding	Clock	IDA		Mouse	MGI:MGI:4410413\|PMID:19605937
Molecular Function	GO:0070888	E-box binding	Clock	IDA		Mouse	MGI:MGI:6282958\|PMID:30012868
Molecular Function	GO:0070888	E-box binding	Clock	IDA		Mouse	MGI:MGI:4820700\|PMID:20106950
Molecular Function	GO:0070888	E-box binding	Clock	IDA		Mouse	MGI:MGI:5553247\|PMID:12738229
Molecular Function	GO:0004402	histone acetyltransferase activity	CLOCK	IMP		Human	PMID:21980503
Molecular Function	GO:0004402	histone acetyltransferase activity	CLOCK	IMP		Human	PMID:28985504
Molecular Function	GO:0004402	histone acetyltransferase activity	Clock	IMP		Mouse	MGI:MGI:3843754\|PMID:19141540
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:O00327	Human	PMID:11018023
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:Q09472	Human	PMID:14645221
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:Q92793	Human	PMID:14645221
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:Q92831	Human	PMID:14645221
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:Q02363	Human	PMID:20861012
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:P29375	Human	PMID:21960634
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:P04150	Human	PMID:21980503
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:O00327	Human	PMID:28388406
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:O00327-8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:Q8WYA1-3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:Q8TC59	Human	PMID:28903391
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:O00327\|UniProtKB:P00966\|UniProtKB:P12268\|UniProtKB:Q16795	Human	PMID:28985504
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:P41235	Human	PMID:30530698
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:O00327	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:O00327-8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLOCK	IPI	UniProtKB:Q8WYA1-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q8R0W1	Mouse	MGI:MGI:5532917\|PMID:17310242
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q569Z6\|UniProtKB:Q925J9	Mouse	MGI:MGI:5511073\|PMID:24043798
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O54943\|UniProtKB:P97784	Mouse	MGI:MGI:3829113\|PMID:18430226
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O54943\|UniProtKB:P97784\|UniProtKB:Q9WTL8	Mouse	MGI:MGI:5489023\|PMID:23555304
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P30154\|UniProtKB:P36873\|UniProtKB:P51449\|UniProtKB:P62136\|UniProtKB:P62140\|UniProtKB:P67870\|UniProtKB:Q14738\|UniProtKB:Q14995\|UniProtKB:Q92753\|UniProtKB:Q9JMK2	Mouse	MGI:MGI:5489023\|PMID:23555304
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q8K4B0	Mouse	MGI:MGI:5582861\|PMID:24089055
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5294528\|PMID:20840750
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q8CDG1	Mouse	MGI:MGI:6285118\|PMID:28903391
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5431019\|PMID:22441692
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q3UXZ9	Mouse	MGI:MGI:5288521\|PMID:21960634
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8-4	Mouse	MGI:MGI:5918767\|PMID:25961797
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O54943\|UniProtKB:P97784\|UniProtKB:Q923E4\|UniProtKB:Q9WTL8	Mouse	MGI:MGI:3807721\|PMID:18662546
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O54943	Mouse	MGI:MGI:5014424\|PMID:21680841
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q923E4\|UniProtKB:Q9WTL8	Mouse	MGI:MGI:3807720\|PMID:18662547
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P97784	Mouse	MGI:MGI:5918767\|PMID:25961797
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P97784\|UniProtKB:Q9R194	Mouse	MGI:MGI:3027197\|PMID:14701732
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q7TPV4	Mouse	MGI:MGI:5009503\|PMID:19129230
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P41134\|UniProtKB:Q02363\|UniProtKB:Q02535	Mouse	MGI:MGI:5574297\|PMID:20861012
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8-4	Mouse	MGI:MGI:5442460\|PMID:22653727
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O35973\|UniProtKB:O54943\|UniProtKB:P97784\|UniProtKB:Q61188\|UniProtKB:Q9R194	Mouse	MGI:MGI:3694308\|PMID:16717091
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5607228\|PMID:21113167
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q03164	Mouse	MGI:MGI:5607228\|PMID:21113167
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8-2	Mouse	MGI:MGI:3771941\|PMID:18075593
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P97784\|UniProtKB:Q9WTL8	Mouse	MGI:MGI:3771941\|PMID:18075593
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P55200	Mouse	MGI:MGI:5607228\|PMID:21113167
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P97784\|UniProtKB:Q9WTL8	Mouse	MGI:MGI:3652692\|PMID:16777965
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:1276614\|PMID:9704006
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:4455093\|PMID:20211142
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q61026	Mouse	MGI:MGI:5607392\|PMID:24529706
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5568139\|PMID:24737000
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5700567\|PMID:26562092
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P63073\|UniProtKB:Q61496\|UniProtKB:Q9JMB7	Mouse	MGI:MGI:5447260\|PMID:22900038
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O35973	Mouse	MGI:MGI:5543956\|PMID:24154698
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5508740\|PMID:17347670
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:6383282\|PMID:28388406
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q3U1J4	Mouse	MGI:MGI:5919179\|PMID:26323038
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P20444	Mouse	MGI:MGI:5508740\|PMID:17347670
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5919179\|PMID:26323038
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O54943\|UniProtKB:P97784	Mouse	MGI:MGI:5567903\|PMID:21613214
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q04207	Mouse	MGI:MGI:5447078\|PMID:22895791
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5500838\|PMID:23735699
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:O54943\|UniProtKB:Q9WTL8	Mouse	MGI:MGI:4881368\|PMID:20832105
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P04150	Mouse	MGI:MGI:3843754\|PMID:19141540
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:P16460	Mouse	MGI:MGI:6103563\|PMID:28985504
Molecular Function	GO:0005515	protein binding	Clock	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:5442460\|PMID:22653727
Molecular Function	GO:0005515	protein binding	Clock	IPI	PR:P45481	Mouse	PMID:16606840
Molecular Function	GO:0005515	protein binding	clockb	IPI	UniProtKB:A4QN37	Zfish	PMID:17785416
Molecular Function	GO:0005515	protein binding	clocka	IPI	RefSeq:NP_571653	Zfish	PMID:10760301
Molecular Function	GO:0005515	protein binding	clocka	IPI	UniProtKB:Q9I879	Zfish	PMID:17785416
Molecular Function	GO:0005515	protein binding	clocka	IPI	UniProtKB:A4QN37	Zfish	PMID:17785416
Molecular Function	GO:0005515	protein binding	clocka	IPI	RefSeq:NP_571652	Zfish	PMID:10760301
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	CLOCK	IDA		Human	PMID:18411297
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:3843127\|PMID:19299583
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5582861\|PMID:24089055
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5511073\|PMID:24043798
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5297789\|PMID:15147242
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5545849\|PMID:24385426
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5574290\|PMID:22894897
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5607228\|PMID:21113167
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5613453\|PMID:24051492
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5292598\|PMID:21768648
Molecular Function	GO:0043565	sequence-specific DNA binding	Clock	IDA		Mouse	MGI:MGI:5567903\|PMID:21613214
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	CLOCK	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	clocka	IDA		Zfish	ZFIN:ZDB-PUB-170709-3
Cellular Component	GO:0000785	chromatin	clocka	IDA		Zfish	PMID:28687631
Cellular Component	GO:0033391	chromatoid body	Clock	IDA		Mouse	MGI:MGI:5447260\|PMID:22900038
Cellular Component	GO:0005694	chromosome	CLOCK	IDA		Human	PMID:21659603
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	CLOCK	IPI		Human	PMID:10864977
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	CLOCK	IPI		Human	PMID:23229515
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	Clock	IPI		Mouse	MGI:MGI:5918767\|PMID:25961797
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	Clock	IPI		Mouse	MGI:MGI:5442460\|PMID:22653727
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	clocka	IDA		Zfish	PMID:29447387
Cellular Component	GO:0005737	cytoplasm	Clock	IDA		Mouse	MGI:MGI:5607219\|PMID:22208286
Cellular Component	GO:0005737	cytoplasm	Clock	IDA		Mouse	MGI:MGI:5574297\|PMID:20861012
Cellular Component	GO:0005737	cytoplasm	Clock	IDA		Mouse	PMID:12897057
Cellular Component	GO:0005829	cytosol	CLOCK	IDA		Human	PMID:28985504
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CLOCK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	Clock	IDA		Rat	PMID:16208722\|RGD:10401943
Cellular Component	GO:0005654	nucleoplasm	CLOCK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CLOCK	IDA		Human	PMID:12738229
Cellular Component	GO:0005634	nucleus	CLOCK	IDA		Human	PMID:14645221
Cellular Component	GO:0005634	nucleus	CLOCK	IDA		Human	PMID:23229515
Cellular Component	GO:0005634	nucleus	CLOCK	IDA		Human	PMID:28985504
Cellular Component	GO:0005634	nucleus	Clock	IDA		Mouse	MGI:MGI:5442460\|PMID:22653727
Cellular Component	GO:0005634	nucleus	Clock	IDA		Mouse	MGI:MGI:5918767\|PMID:25961797
Cellular Component	GO:0005634	nucleus	Clock	IDA		Mouse	MGI:MGI:5574297\|PMID:20861012
Cellular Component	GO:0005634	nucleus	Clock	IDA		Mouse	MGI:MGI:5532917\|PMID:17310242
Cellular Component	GO:0005634	nucleus	Clock	IDA		Mouse	MGI:MGI:3807721\|PMID:18662546
Cellular Component	GO:0005634	nucleus	Clock	IDA		Mouse	PMID:12897057
Cellular Component	GO:0005634	nucleus	Clock	IDA		Rat	PMID:22356123\|RGD:8661632
Cellular Component	GO:0005726	perichromatin fibrils	Clock	IDA		Rat	PMID:16208722\|RGD:10401943
Cellular Component	GO:0032991	protein-containing complex	clocka	IDA		Zfish	PMID:15591021
Cellular Component	GO:0005791	rough endoplasmic reticulum	Clock	IDA		Rat	PMID:16208722\|RGD:10401943
Cellular Component	GO:0005667	transcription regulator complex	Clock	IDA		Mouse	MGI:MGI:5442460\|PMID:22653727
Cellular Component	GO:0005667	transcription regulator complex	Clock	IDA		Mouse	PMID:16606840
Cellular Component	GO:0005667	transcription regulator complex	clocka	IDA		Zfish	PMID:15591021
Biological Process	GO:0071479	cellular response to ionizing radiation	CLOCK	IDA		Human	PMID:21659603
Biological Process	GO:0032922	circadian regulation of gene expression	CLOCK	IDA		Human	PMID:10864977
Biological Process	GO:0032922	circadian regulation of gene expression	CLOCK	IMP		Human	PMID:21980503
Biological Process	GO:0032922	circadian regulation of gene expression	CLOCK	IDA		Human	PMID:23229515
Biological Process	GO:0032922	circadian regulation of gene expression	CLOCK	IDA		Human	PMID:24005054
Biological Process	GO:0032922	circadian regulation of gene expression	CLOCK	IMP		Human	PMID:28985504
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:3843127\|PMID:19299583
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:2683983\|PMID:14672706
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:6282958\|PMID:30012868
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:5503234\|PMID:23785138
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:5442460\|PMID:22653727
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:4837055\|PMID:20430893
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:5297789\|PMID:15147242
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:5292598\|PMID:21768648
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:3794495\|PMID:18316400
Biological Process	GO:0032922	circadian regulation of gene expression	Clock	IMP		Mouse	MGI:MGI:3843754\|PMID:19141540
Biological Process	GO:0032922	circadian regulation of gene expression	clocka	IMP	ZFIN:ZDB-MRPHLNO-050119-1	Zfish	PMID:23468616
Biological Process	GO:0032922	circadian regulation of gene expression	clocka	IMP	ZFIN:ZDB-MRPHLNO-050119-1	Zfish	PMID:18687681
Biological Process	GO:0007623	circadian rhythm	Clock	IEP		Mouse	MGI:MGI:5559671\|PMID:14645221
Biological Process	GO:0007623	circadian rhythm	Clock	IMP	MGI:MGI:1861634	Mouse	PMID:8171325
Biological Process	GO:0007623	circadian rhythm	Clock	IMP	MGI:MGI:1861634	Mouse	PMID:12024206
Biological Process	GO:0007623	circadian rhythm	Clock	IDA		Mouse	PMID:12897057
Biological Process	GO:0007623	circadian rhythm	Clock	IEP		Rat	PMID:10471199\|RGD:10401879
Biological Process	GO:0007623	circadian rhythm	clockb	IGI	ZFIN:ZDB-MRPHLNO-050119-4,ZFIN:ZDB-MRPHLNO-050420-2,ZFIN:ZDB-MRPHLNO-050420-3,ZFIN:ZDB-MRPHLNO-050420-4	Zfish	PMID:15657039
Biological Process	GO:0007623	circadian rhythm	clocka	IGI	ZFIN:ZDB-MRPHLNO-050119-4,ZFIN:ZDB-MRPHLNO-050420-2,ZFIN:ZDB-MRPHLNO-050420-4,ZFIN:ZDB-MRPHLNO-050420-5	Zfish	PMID:15657039
Biological Process	GO:0007623	circadian rhythm	clocka	IMP	ZFIN:ZDB-GENO-081009-7	Zfish	PMID:18569451
Biological Process	GO:0000077	DNA damage checkpoint signaling	CLOCK	IMP		Human	PMID:21659603
Biological Process	GO:0009649	entrainment of circadian clock	Clock	IEP		Rat	PMID:10095082\|RGD:632379
Biological Process	GO:0007565	female pregnancy	Clock	IEP		Rat	PMID:21771885\|RGD:10401948
Biological Process	GO:0007498	mesoderm development	clocka	IGI	ZFIN:ZDB-GENE-000509-3	Zfish	PMID:28687631
Biological Process	GO:0007498	mesoderm development	clocka	IGI	ZFIN:ZDB-GENE-990415-256	Zfish	PMID:28687631
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5567887\|PMID:24378737
Biological Process	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	Clock	IDA		Mouse	MGI:MGI:5567887\|PMID:24378737
Biological Process	GO:0009648	photoperiodism	clockb	IEP		Zfish	PMID:12354100
Biological Process	GO:0009648	photoperiodism	clocka	IEP		Zfish	PMID:11517315
Biological Process	GO:0009648	photoperiodism	clocka	IDA		Zfish	PMID:10716448
Biological Process	GO:0009648	photoperiodism	clocka	IEP		Zfish	PMID:12354100
Biological Process	GO:0042753	positive regulation of circadian rhythm	CLOCK	IDA		Human	PMID:12738229
Biological Process	GO:0042753	positive regulation of circadian rhythm	CLOCK	IDA		Human	PMID:23229515
Biological Process	GO:0042753	positive regulation of circadian rhythm	Clock	IMP		Mouse	MGI:MGI:5442460\|PMID:22653727
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CLOCK	IDA		Human	PMID:10864977
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CLOCK	IDA		Human	PMID:23229515
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CLOCK	IDA		Human	PMID:23785138
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:4410413\|PMID:19605937
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:2388855\|PMID:12397359
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5918767\|PMID:25961797
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5568140\|PMID:24736997
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5553247\|PMID:12738229
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5442460\|PMID:22653727
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:3843127\|PMID:19299583
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5292598\|PMID:21768648
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IMP		Mouse	MGI:MGI:4837055\|PMID:20430893
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:3794495\|PMID:18316400
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5582861\|PMID:24089055
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Clock	IDA		Rat	PMID:22356123\|RGD:8661632
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	clocka	IMP		Zfish	PMID:15591021
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	clocka	IGI	ZFIN:ZDB-GENE-000509-1	Zfish	PMID:15591021
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	clocka	IMP		Zfish	PMID:18800057
Biological Process	GO:0010628	positive regulation of gene expression	clocka	IGI	ZFIN:ZDB-GENE-030408-1	Zfish	PMID:27171500
Biological Process	GO:0050729	positive regulation of inflammatory response	Clock	IMP		Mouse	MGI:MGI:5574290\|PMID:22894897
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Clock	IMP		Mouse	MGI:MGI:5447078\|PMID:22895791
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Clock	IDA		Mouse	MGI:MGI:5297789\|PMID:15147242
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Clock	IDA		Mouse	MGI:MGI:2683983\|PMID:14672706
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Clock	IDA		Mouse	MGI:MGI:5430897\|PMID:15193144
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Clock	IDA		Mouse	PMID:19217292
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Clock	IGI	MGI:MGI:1096381	Mouse	PMID:16606840
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	clocka	IDA		Zfish	ZFIN:ZDB-PUB-170709-3
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	clocka	IMP	ZFIN:ZDB-MRPHLNO-050119-1	Zfish	ZFIN:ZDB-PUB-170709-3
Biological Process	GO:0060215	primitive hemopoiesis	clocka	IGI	ZFIN:ZDB-GENE-000509-3	Zfish	PMID:28687631
Biological Process	GO:0060215	primitive hemopoiesis	clocka	IGI	ZFIN:ZDB-GENE-990415-256	Zfish	PMID:28687631
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Clock	IDA		Mouse	MGI:MGI:5495336\|PMID:23395176
Biological Process	GO:0006473	protein acetylation	CLOCK	IDA		Human	PMID:28985504
Biological Process	GO:0006473	protein acetylation	Clock	IDA		Mouse	MGI:MGI:6103563\|PMID:28985504
Biological Process	GO:0042752	regulation of circadian rhythm	Clock	IMP		Mouse	MGI:MGI:6282958\|PMID:30012868
Biological Process	GO:0006355	regulation of DNA-templated transcription	Clock	IDA		Mouse	MGI:MGI:5442460\|PMID:22653727
Biological Process	GO:0006355	regulation of DNA-templated transcription	Clock	IDA		Mouse	PMID:12024206
Biological Process	GO:0010468	regulation of gene expression	clocka	IGI	ZFIN:ZDB-GENE-010426-3,ZFIN:ZDB-GENE-030408-1	Zfish	PMID:27171500
Biological Process	GO:0042634	regulation of hair cycle	CLOCK	IMP		Human	PMID:24005054
Biological Process	GO:0050796	regulation of insulin secretion	Clock	IMP		Mouse	MGI:MGI:4819446\|PMID:20562852
Biological Process	GO:2000074	regulation of type B pancreatic cell development	Clock	IMP		Mouse	MGI:MGI:4819446\|PMID:20562852
Biological Process	GO:0009416	response to light stimulus	Clock	IEP		Rat	PMID:10471199\|RGD:10401879
Biological Process	GO:0009416	response to light stimulus	clockb	IGI	ZFIN:ZDB-MRPHLNO-050119-4,ZFIN:ZDB-MRPHLNO-050420-2,ZFIN:ZDB-MRPHLNO-050420-3,ZFIN:ZDB-MRPHLNO-050420-4	Zfish	PMID:15657039
Biological Process	GO:0009416	response to light stimulus	clocka	IDA		Zfish	PMID:16176122
Biological Process	GO:0009416	response to light stimulus	clocka	IGI	ZFIN:ZDB-MRPHLNO-050119-4,ZFIN:ZDB-MRPHLNO-050420-2,ZFIN:ZDB-MRPHLNO-050420-4,ZFIN:ZDB-MRPHLNO-050420-5	Zfish	PMID:15657039
Biological Process	GO:0051775	response to redox state	CLOCK	IDA		Human	PMID:11441146
Biological Process	GO:0009266	response to temperature stimulus	clocka	IDA		Zfish	PMID:16176122
Biological Process	GO:0007283	spermatogenesis	Clock	IMP		Mouse	MGI:MGI:5447260\|PMID:22900038

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.