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Clock Gene Detail
Summary
  • Symbol
    Clock
  • Name
    circadian locomotor output cycles kaput
  • Synonyms
    5330400M04Rik, bHLHe8, KAT13D, mKIAA0334
  • Feature Type
    protein coding gene
  • IDs
    MGI:99698
    NCBI Gene: 12753
  • Gene Overview
    MyGene.info: CLOCK
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76209868-76304792 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.63 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99698
protein coding gene Chr5:76209868-76305000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029642
protein coding gene Chr5:76386417-76476727 (-)
A/J MGP_AJ_G0029610
protein coding gene Chr5:73462202-73554581 (-)
AKR/J MGP_AKRJ_G0029558
protein coding gene Chr5:75850793-75950769 (-)
BALB/cJ MGP_BALBcJ_G0029619
protein coding gene Chr5:74206978-74302693 (-)
C3H/HeJ MGP_C3HHeJ_G0029342
protein coding gene Chr5:76240312-76333710 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030073
protein coding gene Chr5:79449078-79538913 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027314
protein coding gene Chr5:69125168-69207568 (-)
CAST/EiJ MGP_CASTEiJ_G0028750
protein coding gene Chr5:75421467-75513468 (-)
CBA/J MGP_CBAJ_G0029311
protein coding gene Chr5:82035080-82141119 (-)
DBA/2J MGP_DBA2J_G0029456
protein coding gene Chr5:73543181-73630621 (-)
FVB/NJ MGP_FVBNJ_G0029417
protein coding gene Chr5:72717872-72813599 (-)
LP/J MGP_LPJ_G0029543
protein coding gene Chr5:76827213-76917066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029445
protein coding gene Chr5:85220191-85323286 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030106
protein coding gene Chr5:75417920-75507215 (-)
PWK/PhJ MGP_PWKPhJ_G0028473
protein coding gene Chr5:72546476-72636805 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028308
protein coding gene Chr5:74782742-74865298 (-)
WSB/EiJ MGP_WSBEiJ_G0028830
protein coding gene Chr5:75725726-75814236 (-)



Homology
more
  • Human Ortholog
    CLOCK, clock circadian regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLOCK, clock circadian regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe8, KAT13D
  • Links
    NCBI Gene ID: 9575
    neXtProt AC: NX_O15516
    UniProt: O15516

  • Chr Location
    4q12; chr4:55427901-55547138 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3603
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLOCK
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Clock mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 6 alleles in 15 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029238 Ensembl Gene Model | MGI Sequence Detail 94925 C57BL/6J ±  kb
    transcript ENSMUST00000202651 Ensembl | MGI Sequence Detail 9744 Not Applicable  
    polypeptide ENSMUSP00000143939 Ensembl | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 10
      cDNA 25
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16483, MGI:2442107
    References
    more
    • Summaries
      All 297
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 67
      Phenotypes 158
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:263802 Luciano AK, et al., CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. J Biol Chem. 2018 Jun 8;293(23):9126-9136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    01/15/2019
    MGI 6.13
    The Jackson Laboratory