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Clock Gene Detail
Summary
  • Symbol
    Clock
  • Name
    circadian locomotor output cycles kaput
  • Synonyms
    5330400M04Rik, bHLHe8, KAT13D, mKIAA0334
  • Feature Type
    protein coding gene
  • IDs
    MGI:99698
    NCBI Gene: 12753
  • Gene Overview
    MyGene.info: CLOCK
Location & Maps
more
  • Sequence Map
    Chr5:76209868-76304792 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94925 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.63 cM
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    CLOCK, clock circadian regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLOCK, clock circadian regulator
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe8, KAT13D
  • Links
    NCBI Gene ID: 9575
    neXtProt AC: NX_O15516

  • Chr Location
    4q12; chr4:55427901-55546909 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3603
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CLOCK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    76 phenotypes from 5 alleles in 14 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    62
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    51
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    3
  • Genomic Mutations
    3 involving Clock
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056120 VEGA Gene Model | MGI Sequence Detail 94925 C57BL/6J ±  kb
transcript OTTMUST00000138780 VEGA | MGI Sequence Detail 9744 Not Applicable  
polypeptide OTTMUSP00000072919 VEGA | MGI Sequence Detail 855 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    245 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 38
    Genomic 10
    cDNA 24
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16483, MGI:2442107
References
more
  • Summaries
    All 229
    Developmental Gene Expression 10
    Gene Ontology 60
    Phenotypes 132
  • Earliest
    J:18005 Vitaterna MH, et al., Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science. 1994 Apr 29;264(5159):719-25
  • Latest
    J:232340 Landgraf D, et al., NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators. PLoS Genet. 2016 Feb;12(2):e1005882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory