About   Help   FAQ
Clock
Gene Detail
 Symbol
Name
ID
Clock
circadian locomotor output cycles kaput
MGI:99698
Synonyms 5330400M04Rik, bHLHe8, KAT13D, mKIAA0334
Feature Type protein coding gene
Genetic Map
Chromosome 5
40.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr5:76212177-76304548 bp, - strand
From NCBI annotation of GRCm38

  92372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Clock

Human
homologs
Human Homolog CLOCK, clock circadian regulator
NCBI Gene ID 9575
neXtProt AC  NX_O15516
Human Synonyms  bHLHe8, KAT13D
Human Chr (Location)  4q12; chr4:55427901-55546909 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Chemically induced (ENU)(1) Gene trapped(50) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.
 
Interactions
Clock interacts with 476 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process cellular response to DNA damage stimulus, cellular response to ionizing radiation, ...
Component chromatoid body, chromosome, ...
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (175)    Tissues (156)    Images (22)
Theiler Stages: 1, 2, 3, 4, 5, 17, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 138
RT-PCR 33
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(10) cDNA(24) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000029238 (Evidence)
Entrez Gene12753 (Evidence)
DoTSDT.101230942, DT.528388, DT.55142600, DT.97357726, DT.99839908, DT.99839909
NIA Mouse Gene IndexU026318
EC2.3.1.48
PDB4F3L
Consensus CDS ProjectCCDS19360.1
International Mouse Knockout Project StatusClock
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12753 NCBI Gene Model | MGI Sequence Detail 92372 C57BL/6J ±  kb
transcript NM_007715 RefSeq | MGI Sequence Detail 9801 C57BL/6 
polypeptide O08785 UniProt | EBI | MGI Sequence Detail 855 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(16) UniProt(6)
Polymorphisms SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001067 Nuclear translocator
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000005597 circadian locomoter output cycles protein kaput
Graphical View of Protein Domain Structure
References (Earliest) J:18005 Vitaterna MH, et al., Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science. 1994 Apr 29;264(5159):719-25
(Latest) J:210850 Matsunaga N, et al., 24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks. J Invest Dermatol. 2014 Jun;134(6):1636-44
All references(209)
Other
accession IDs
MGD-MRK-16483, MGI:2442107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory