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Clock Gene Detail
Summary
  • Symbol
    Clock
  • Name
    clock circadian regulator
  • Synonyms
    5330400M04Rik, bHLHe8, KAT13D, mKIAA0334
  • Feature Type
    protein coding gene
  • IDs
    MGI:99698
    NCBI Gene: 12753
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76357715-76452639 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 40.63 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1460 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99698
 protein coding gene Chr5:76357715-76452675 (-)
129S1/SvImJ ENSMUSG00200000884
 protein coding gene Chr5:72048143-72142828 (-)
A/J ENSMUSG00195010311
 protein coding gene Chr5:71344917-71439588 (-)
AKR/J ENSMUSG00220014706
 protein coding gene Chr5:71458083-71552763 (-)
BALB/cJ ENSMUSG00180023006
 protein coding gene Chr5:71119604-71214538 (-)
C3H/HeJ ENSMUSG00175004209
 protein coding gene Chr5:73163445-73258358 (-)
C57BL/6NJ ENSMUSG00215000438
 protein coding gene Chr5:71934188-72029118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027314
 protein coding gene Chr5:69125168-69207568 (-)
CAST/EiJ ENSTCUG00005013598
 protein coding gene Chr5:70909942-71000218 (-)
CBA/J ENSMUSG00210000442
 protein coding gene Chr5:72101436-72196362 (-)
DBA/2J ENSMUSG00185016304
 protein coding gene Chr5:73931382-74026309 (-)
FVB/NJ ENSMUSG00205017765
 protein coding gene Chr5:70867937-70962612 (-)
JF1/MsJ ENSUMUG00000004744
 protein coding gene Chr5:78413268-78495829 (-)
LP/J ENSMUSG00230021019
 protein coding gene Chr5:78622142-78716827 (-)
NOD/ShiLtJ ENSMUSG00190007677
 protein coding gene Chr5:71051759-71146748 (-)
NZO/HlLtJ ENSMUSG00225033023
 protein coding gene Chr5:83668857-83763778 (-)
PWK/PhJ ENSLUMG00010007262
 protein coding gene Chr5:71005596-71089226 (-)
SPRET/EiJ ENSMSPG00010008887
 protein coding gene Chr5:72997293-73078119 (-)
WSB/EiJ ENSIUOG00005018010
 protein coding gene Chr5:73881346-73976249 (-)



Homology
more
  • Human Ortholog
    CLOCK, clock circadian regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLOCK, clock circadian regulator
  • Synonyms
    bHLHe8, KAT13D
  • Links
    NCBI Gene ID: 9575
    UniProt: O15516

  • Chr Location
    4q12; chr4:55427903-55547491 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Clock mouse models; 2 with human CLOCK associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 7 alleles in 16 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    231 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    144
  • GO References
    83
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1000
  • Tissues
    205
  • cDNA Data
    25
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029238 Ensembl Gene Model | MGI Sequence Detail 94925 C57BL/6J ±  kb
    transcript ENSMUST00000075159 Ensembl | MGI Sequence Detail 7478 Not Applicable  
    polypeptide ENSMUSP00000074656 Ensembl | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 10
      cDNA 25
      Primer pair 7
      Other 1
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16483, MGI:2442107
    References
    more
    • Summaries
      All 494
      Developmental Gene Expression 21
      Diseases 3
      Gene Ontology 83
      Phenotypes 231
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:377727 Zhang Y, et al., Circadian Clock Dysfunction Exacerbate Autistic-Like Behaviour and Wnt/beta-Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin. J Cell Mol Med. 2026 Jan;30(1):e70991
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory