Clock
Gene Detail

Symbol Name ID

Clock circadian locomotor output cycles kaput MGI:99698

Synonyms

5330400M04Rik, bHLHe8, KAT13D, mKIAA0334

Feature Type

protein coding gene

Genetic Map

Chromosome 5

40.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr5:76212177-76304548 bp, - strand From NCBI annotation of GRCm38   92372 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Clock

Human homologs

Human Homolog		CLOCK, clock circadian regulator
NCBI Gene ID		9575
neXtProt AC		NX_O15516
Human Synonyms		bHLHe8, KAT13D
Human Chr (Location)		4q12; chr4:56294068-56413076 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(54) : Targeted(3) Gene trapped(50) Chemically induced(1)
 

Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	cellular response to ionizing radiation, circadian regulation of gene expression, ...
Component	chromosome, cytoplasm, ...
Function	DNA binding, E-box binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (175)    Tissues (156)    Images (22)
Theiler Stages: 1, 2, 3, 4, 5, 17, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	138
RT-PCR	33

cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(10) cDNA(23) Primer pair(4)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000029238 (Evidence)
Entrez Gene	12753 (Evidence)
DoTS	DT.101230942, DT.528388, DT.55142600, DT.97357726, DT.99839908, DT.99839909
NIA Mouse Gene Index	U026318
EC	2.3.1.48
PDB	4F3L
Consensus CDS Project	CCDS19360.1
International Mouse Knockout Project Status	Clock

Sequences

Length	Strain/Species
genomic	12753	NCBI Gene Model | MGI Sequence Detail	92372	C57BL/6J
transcript	NM_007715	RefSeq | MGI Sequence Detail	7478	C57BL/6
polypeptide	O08785	UniProt | EBI | MGI Sequence Detail	855	Not Applicable

All sequences(38) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(199 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR001067	Nuclear translocator
InterPro	IPR001610	PAC motif
InterPro	IPR000014	PAS domain
InterPro	IPR013767	PAS fold
InterPro	IPR013655	PAS fold-3
Protein Ontology	PR:000005597	circadian locomoter output cycles protein kaput

Graphical View of Protein Domain Structure

References

(Earliest) J:18005 Vitaterna MH, et al., Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science. 1994 Apr 29;264(5159):719-25
(Latest) J:193829 Masri S, et al., Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44
All references(172)

Other accession IDs

MGD-MRK-16483, MGI:2442107