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Clock
Gene Detail
Symbol

Name
ID
Clock
circadian locomotor output cycles kaput
MGI:99698
Synonyms
5330400M04Rik, bHLHe8, KAT13D, mKIAA0334
Feature Type
protein coding gene
Genetic Map
Chromosome 5
40.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr5:76209868-76304792 bp, - strand
From VEGA annotation of GRCm38

  94925 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLOCK
Gene Tree: Clock

Human
homologs
CLOCK, clock circadian regulator
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9575
neXtProt AC: NX_O15516

Human Synonyms: bHLHe8, KAT13D

Human Chr (Location): 4q12; chr4:55427901-55546909 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Chemically induced (ENU)(1) Gene trapped(50) Targeted(4) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.
 
Interactions
Clock interacts with 475 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process cellular response to DNA damage stimulus, cellular response to ionizing radiation, ...
Component chromatoid body, chromosome, ...
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (162)    Tissues (152)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 138
RT-PCR 20
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CLOCK ; Xenbase clock ; ZFIN clocka, clockb    NEW 
Molecular
reagents
All nucleic(38) Genomic(10) cDNA(24) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000056120 (Evidence)
Ensembl Gene Model ENSMUSG00000029238 (Evidence)
Entrez Gene 12753 (Evidence)
DoTS DT.101230942, DT.528388, DT.55142600, DT.97357726, DT.99839908, DT.99839909
NIA Mouse Gene Index U026318
EC 2.3.1.48
PDB 4F3L
Consensus CDS Project CCDS19360.1
International Mouse Phenotyping Consortium Status Clock
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056120 VEGA Gene Model | MGI Sequence Detail 94925 C57BL/6J ±  kb
transcript OTTMUST00000138780 VEGA | MGI Sequence Detail 9744 Not Applicable 
polypeptide OTTMUSP00000072919 VEGA | MGI Sequence Detail 855 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(18) UniProt(6)
Polymorphisms
SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001067 Nuclear translocator
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000005597 circadian locomoter output cycles protein kaput
References
(Earliest) J:18005 Vitaterna MH, et al., Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science. 1994 Apr 29;264(5159):719-25
(Latest) J:221601 Kobayashi Y, et al., Clock genes control cortical critical period timing. Neuron. 2015 Apr 8;86(1):264-75
All references(226)
Other
accession IDs
MGD-MRK-16483, MGI:2442107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory