Clock Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Clock
clock circadian regulator
MGI:99698

97 phenotypes from 7 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Clock^{em1(IMPC)Ccpcz}/Clock^{em1(IMPC)Ccpcz} C57BL/6NCrl-Clock^{em1(IMPC)Ccpcz}/Ccpcz	abnormal skin morphology	J:211773
	abnormal thymus morphology	J:211773
	abnormal tooth morphology	J:211773
	decreased CD8-positive, naive alpha-beta T cell number	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating total protein level	J:211773
	decreased effector memory T-helper cell number	J:211773
	decreased heart rate	J:211773
	decreased lung compliance	J:211773
	decreased red blood cell distribution width	J:211773
	decreased spleen weight	J:211773
	enlarged thymus	J:211773
	increased CD4-positive, alpha-beta T cell number	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased circulating triglyceride level	J:211773
	increased eosinophil cell number	J:211773
	increased leukocyte cell number	J:211773
	increased lung elastance	J:211773
	increased lymphocyte cell number	J:211773
	increased T-helper cell number	J:211773
Clock^m1Btlr/Clock^m1Btlr C57BL/6J-Clock^m1Btlr	increased body weight	J:264640
Clock^m1Jt/Clock⁺ B6(C)-Clock^m1Jt	prolonged circadian behavior period	J:198519
Clock^m1Jt/Clock⁺ C57BL/6-Clock^m1Jt	abnormal behavior	J:101849
	abnormal circadian behavior phase	J:98343
	abnormal sleep duration	J:65198
	abnormal sleep pattern	J:65198
	increased exploration in new environment	J:101849
	increased vertical activity	J:101849
	prolonged circadian behavior period	J:18005, J:198519
Clock^m1Jt/Clock⁺ involves: C57BL/6	abnormal circulating protein level	J:155089
Clock^m1Jt/Clock⁺ involves: C57BL/6	abnormal response to injury	J:155089
Clock^m1Jt/Clock^m1Jt C57BL/6-Clock^m1Jt	abnormal basal metabolism	J:98343
	abnormal behavior	J:101849
	abnormal circadian behavior	J:65198
	abnormal circadian behavior persistence	J:18005
	abnormal circadian behavior phase	J:98343
	abnormal circadian regulation of heart rate	J:125921
	abnormal circadian regulation of systemic arterial blood pressure	J:125921
	abnormal circadian sleep/wake cycle	J:65198
	abnormal eating behavior	J:98343
	abnormal food intake	J:98343
	abnormal hepatocyte physiology	J:98343
	abnormal locomotor circadian rhythm	J:98343
	abnormal sleep duration	J:65198
	abnormal sleep pattern	J:65198
	decreased circulating corticosterone level	J:98343
	decreased energy expenditure	J:98343
	decreased heart rate	J:125921
	hepatic steatosis	J:98343
	hyperactivity	J:98343, J:101849
	increased body weight	J:98343
	increased circulating cholesterol level	J:98343
	increased circulating glucose level	J:98343
	increased circulating leptin level	J:98343
	increased circulating triglyceride level	J:98343
	increased exploration in new environment	J:101849
	increased fat cell size	J:98343
	increased percent body fat/body weight	J:98343
	increased susceptibility to diet-induced obesity	J:98343
	increased vertical activity	J:101849
	prolonged circadian behavior period	J:18005
Clock^m1Jt/Clock^m1Jt C57BL/6J-Clock^m1Jt/J	abnormal enterocyte physiology	J:153782
	abnormal intestinal absorption	J:153782
	abnormal intestinal lipid absorption	J:153782
	increased intestinal glucose absorption	J:153782
Clock^m1Jt/Clock^m1Jt involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR	decreased physiological sensitivity to xenobiotic	J:128504
Clock^m1Jt/Clock^m1Jt involves: BALB/cJ * C57BL/6	arrhythmic circadian behavior persistence	J:18005
	normal nervous system phenotype	J:18005
	prolonged circadian behavior period	J:18005
Clock^m1Jt/Clock^m1Jt involves: BALB/cJ * C57BL/6 * C57BL/6J	abnormal medium spiny neuron morphology	J:166742
	abnormal nervous system electrophysiology	J:166742
	abnormal nucleus accumbens morphology	J:166742
Clock^m1Jt/Clock^m1Jt involves: C57BL/6	abnormal circadian behavior	J:40363
	abnormal circadian behavior phase	J:99868
	abnormal glucose homeostasis	J:131694
	abnormal lipid homeostasis	J:131694
	abnormal luteinizing hormone level	J:92343
	abnormal parturition	J:92343
	abnormal pregnancy	J:92343
	abnormal response to new environment	J:99868
	abnormal single cell response	J:99868
	decreased circulating estradiol level	J:92343
	decreased circulating luteinizing hormone level	J:92343
	decreased circulating progesterone level	J:92343
	decreased physiological sensitivity to xenobiotic	J:92343
	enhanced behavioral response to cocaine	J:99868
	hyperactivity	J:99868
	impaired gluconeogenesis	J:131694
	increased circulating estradiol level	J:92343
	increased circulating progesterone level	J:92343
	increased insulin sensitivity	J:131694
	increased vertical activity	J:99868
	prolonged circadian behavior period	J:40363
	prolonged estrous cycle	J:92343
	prolonged estrus	J:92343
	normal reproductive system phenotype	J:92343
	short proestrus	J:92343
Clock^m1Jt/Clock^m1Jt involves: C57BL/6 * C57BL/6J	abnormal hair cycle	J:151782
Clock^m1Jt/Clock^m1Jt involves: C57BL/6 * C57BL/6J	abnormal hair cycle anagen phase	J:151782
Clock^m1Jt/Clock^m1Jt involves: C57BL/6 * C57BL/6J * Jcl:ICR	abnormal circadian behavior	J:125037
	abnormal circadian behavior phase	J:125037
Clock^m1Jt/Clock^m1Jt involves: C57BL/6 * Jcl:ICR	abnormal circadian behavior	J:103663, J:116792
	abnormal circadian sleep/wake cycle	J:103663, J:116792
	abnormal circadian temperature homeostasis	J:103663, J:116792
	abnormal sleep duration	J:103663
	abnormal sleep pattern	J:103663
	abnormal spatial learning	J:116792
	normal behavior/neurological phenotype	J:116792
	hyperactivity	J:116792
	increased vertical activity	J:116792
Clock^m1Jt/Clock^m1Jt involves: C57BL/6J	abnormal pancreas physiology	J:162641
	abnormal pancreatic islet morphology	J:162641
	decreased insulin secretion	J:162641
	hyperglycemia	J:162641
	impaired glucose tolerance	J:162641
	increased insulin sensitivity	J:162641
	increased pancreatic islet cell apoptosis	J:162641
	insulin resistance	J:162641
	small pancreatic islets	J:162641
Clock^tm1.1Rep/Clock^tm1.1Rep involves: 129S4/SvJae * C57BL/6J	abnormal circadian behavior phase	J:109634
	advanced circadian behavior phase	J:109634
Clock^tm1Jt/Clock^tm1Jt B6.Cg-Clock^tm1Jt	no abnormal phenotype detected	J:101977
Tg(Scg2-tTA)1Jt/0 Tg(tetO-Clock)1Jt/0 involves: C57BL/6J * CD-1	shortened circadian behavior period	J:120326
Tg(Scg2-tTA)1Jt/0 Tg(tetO-Clock^m1Jt)CL57Jt/0 involves: C57BL/6J * CD-1	abnormal circadian behavior phase	J:120326
	abnormal locomotor circadian rhythm	J:120326
	delayed circadian behavior phase	J:120326
	prolonged circadian behavior period	J:120326

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23