Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Capn2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CAPN2
- Mouse genes Capn2
- Rat genes Capn2
- Zfish genes capn2a,capn2b,capn2l
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Capn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Capn2	IDA		Rat	PMID:14976200\|RGD:1578398
Molecular Function	GO:0005509	calcium ion binding	Capn2	IDA		Rat	PMID:17402852\|RGD:2303056
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	CAPN2	IDA		Human	PMID:12150984
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn2	IDA		Mouse	MGI:MGI:5432966\|PMID:22711986
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn2	IDA		Mouse	PMID:22555453
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn2	IDA		Rat	PMID:7982961\|RGD:634695
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn2	IDA		Rat	PMID:14976200\|RGD:1578398
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn2	IDA		Rat	PMID:17402852\|RGD:2303056
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn2	IDA		Rat	PMID:17429681\|RGD:1626249
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn2	IDA		Rat	PMID:22711986\|RGD:8553623
Molecular Function	GO:0008092	cytoskeletal protein binding	Capn2	IDA		Rat	PMID:17429681\|RGD:1626249
Molecular Function	GO:0019899	enzyme binding	Capn2	IPI	RGD:619993	Rat	PMID:20850499\|RGD:13703063
Molecular Function	GO:0008233	peptidase activity	Capn2	IDA		Mouse	PMID:21849499
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P04632	Human	PMID:10639123
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P04632	Human	PMID:18519038
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:Q8IUH5	Human	PMID:24705354
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P04632	Human	PMID:28319173
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:O60356	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P07237	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P60201-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN2	IPI	UniProtKB:Q9P1I4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Capn2	IPI	UniProtKB:Q64537	Rat	PMID:15476820\|RGD:11041056
Molecular Function	GO:0005515	protein binding	Capn2	IPI	UniProtKB:P27321	Rat	PMID:17543955\|RGD:8553978
Molecular Function	GO:0005515	protein binding	Capn2	IPI	UniProtKB:G5EFH4	Rat	PMID:17889653\|RGD:8553611
Molecular Function	GO:0005515	protein binding	Capn2	IPI	UniProtKB:P27321	Rat	PMID:19020622\|RGD:5683624
Molecular Function	GO:0005515	protein binding	Capn2	IPI	UniProtKB:Q64537	Rat	PMID:19020622\|RGD:5683624
Molecular Function	GO:0005515	protein binding	Capn2	IPI	UniProtKB:P27321	Rat	PMID:19020623\|RGD:11531696
Molecular Function	GO:0005515	protein binding	Capn2	IPI	UniProtKB:Q64537	Rat	PMID:19020623\|RGD:11531696
Molecular Function	GO:0005515	protein binding	Capn2	IPI	RGD:1311806	Rat	PMID:19833151\|RGD:13792654
Molecular Function	GO:0044877	protein-containing complex binding	Capn2	IPI	RGD:2270	Rat	PMID:7982961\|RGD:634695
Cellular Component	GO:0110158	calpain complex	CAPN2	IPI		Human	PMID:10639123
Cellular Component	GO:0042995	cell projection	Capn2	IDA		Rat	PMID:12404510\|RGD:13792667
Cellular Component	GO:0000785	chromatin	Capn2	IDA		Mouse	PMID:18415939
Cellular Component	GO:0005737	cytoplasm	Capn2	IDA		Mouse	PMID:18415939
Cellular Component	GO:0005737	cytoplasm	Capn2	IDA		Rat	PMID:22711986\|RGD:8553623
Cellular Component	GO:0005829	cytosol	CAPN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CAPN2	IDA		Human	PMID:12150984
Cellular Component	GO:0005829	cytosol	CAPN2	IDA		Human	PMID:14559243
Cellular Component	GO:0005829	cytosol	Capn2	IDA		Mouse	PMID:22555453
Cellular Component	GO:0005829	cytosol	Capn2	IDA		Rat	PMID:17182728\|RGD:2303057
Cellular Component	GO:0005829	cytosol	Capn2	IDA		Rat	PMID:19833151\|RGD:13792654
Cellular Component	GO:0030425	dendrite	Capn2	IDA		Rat	PMID:22711986\|RGD:8553623
Cellular Component	GO:0005783	endoplasmic reticulum	CAPN2	IDA		Human	PMID:14559243
Cellular Component	GO:0009897	external side of plasma membrane	Capn2	IDA		Rat	PMID:9299163\|RGD:13792660
Cellular Component	GO:0070062	extracellular exosome	CAPN2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CAPN2	HDA		Human	PMID:19199708
Cellular Component	GO:0005925	focal adhesion	CAPN2	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Capn2	IDA		Rat	PMID:24271063\|RGD:13792616
Cellular Component	GO:0005794	Golgi apparatus	CAPN2	IDA		Human	PMID:14559243
Cellular Component	GO:0005764	lysosome	Capn2	IDA		Mouse	PMID:22555453
Cellular Component	GO:0016020	membrane	Capn2	IDA		Rat	PMID:9469158\|RGD:13792664
Cellular Component	GO:0045121	membrane raft	CAPN2	IDA		Human	PMID:12150984
Cellular Component	GO:0045121	membrane raft	CAPN2	IDA		Human	PMID:14559243
Cellular Component	GO:0005758	mitochondrial intermembrane space	Capn2	IDA		Rat	PMID:19833151\|RGD:13792654
Cellular Component	GO:0043025	neuronal cell body	Capn2	IDA		Rat	PMID:12404510\|RGD:13792667
Cellular Component	GO:0005634	nucleus	Capn2	IDA		Mouse	PMID:18415939
Cellular Component	GO:0005634	nucleus	Capn2	IDA		Rat	PMID:25820375\|RGD:13792650
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	CAPN2	IDA		Human	PMID:14559243
Cellular Component	GO:0005886	plasma membrane	CAPN2	IDA		Human	PMID:12150984
Cellular Component	GO:0031143	pseudopodium	CAPN2	IDA		Human	PMID:14559243
Biological Process	GO:0048266	behavioral response to pain	Capn2	IDA		Rat	PMID:25150005\|RGD:13792585
Biological Process	GO:0001824	blastocyst development	Capn2	IMP	MGI:MGI:3628453	Mouse	PMID:16433929
Biological Process	GO:0071230	cellular response to amino acid stimulus	Capn2	IDA		Mouse	MGI:MGI:5432966\|PMID:22711986
Biological Process	GO:0071230	cellular response to amino acid stimulus	Capn2	IDA		Rat	PMID:22711986\|RGD:8553623
Biological Process	GO:0035458	cellular response to interferon-beta	Capn2	IEP		Rat	PMID:23390485\|RGD:13792657
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Capn2	IEP		Rat	PMID:23390485\|RGD:13792657
Biological Process	GO:0007565	female pregnancy	Capn2	IEP		Rat	PMID:24271063\|RGD:13792616
Biological Process	GO:0007520	myoblast fusion	Capn2	IMP		Mouse	PMID:10949052
Biological Process	GO:0007520	myoblast fusion	Capn2	IMP		Mouse	PMID:14618389
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Capn2	IMP		Rat	PMID:21268078\|RGD:13792651
Biological Process	GO:1901741	positive regulation of myoblast fusion	Capn2	IMP		Rat	PMID:7657725\|RGD:13792659
Biological Process	GO:1901216	positive regulation of neuron death	Capn2	IMP		Rat	PMID:19141074\|RGD:13792555
Biological Process	GO:2001247	positive regulation of phosphatidylcholine biosynthetic process	Capn2	IMP		Rat	PMID:9481489\|RGD:13792658
Biological Process	GO:0016540	protein autoprocessing	Capn2	IDA		Rat	PMID:17182728\|RGD:2303057
Biological Process	GO:0030163	protein catabolic process	Capn2	IDA		Rat	PMID:17402852\|RGD:2303056
Biological Process	GO:0030163	protein catabolic process	Capn2	IDA		Rat	PMID:17429681\|RGD:1626249
Biological Process	GO:0006508	proteolysis	Capn2	IDA		Mouse	MGI:MGI:5432966\|PMID:22711986
Biological Process	GO:0006508	proteolysis	Capn2	IDA		Rat	PMID:22711986\|RGD:8553623
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CAPN2	IDA		Human	PMID:12150984
Biological Process	GO:0032675	regulation of interleukin-6 production	Capn2	IMP		Rat	PMID:25150005\|RGD:13792585
Biological Process	GO:0042542	response to hydrogen peroxide	Capn2	IEP		Rat	PMID:15101113\|RGD:13792670
Biological Process	GO:0001666	response to hypoxia	Capn2	IEP		Rat	PMID:15979593\|RGD:1578397
Biological Process	GO:0009612	response to mechanical stimulus	Capn2	IEP		Rat	PMID:17182728\|RGD:2303057

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.