About   Help   FAQ
Capn2 Gene Detail
Summary
  • Symbol
    Capn2
  • Name
    calpain 2
  • Synonyms
    Capa2, Capa-2, m-calpain
  • Feature Type
    protein coding gene
  • IDs
    MGI:88264
    NCBI Gene: 12334
  • Gene Overview
    MyGene.info: CAPN2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182467259-182517483 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    917 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88264
protein coding gene Chr1:182467259-182517608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016895
protein coding gene Chr1:189097610-189151059 (-)
A/J MGP_AJ_G0016874
protein coding gene Chr1:181390308-181441443 (-)
AKR/J MGP_AKRJ_G0016839
protein coding gene Chr1:186765703-186815144 (-)
BALB/cJ MGP_BALBcJ_G0016832
protein coding gene Chr1:182023582-182073899 (-)
C3H/HeJ MGP_C3HHeJ_G0016656
protein coding gene Chr1:187582392-187632462 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017295
protein coding gene Chr1:195197873-195249742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015002
protein coding gene Chr1:172460485-172511865 (-)
CAST/EiJ MGP_CASTEiJ_G0016238
protein coding gene Chr1:186925861-186980702 (-)
CBA/J MGP_CBAJ_G0016630
protein coding gene Chr1:202442205-202496305 (-)
DBA/2J MGP_DBA2J_G0016736
protein coding gene Chr1:180167584-180217095 (-)
FVB/NJ MGP_FVBNJ_G0016732
protein coding gene Chr1:178304419-178354948 (-)
LP/J MGP_LPJ_G0016811
protein coding gene Chr1:190291343-190341729 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016764
protein coding gene Chr1:209448523-209499676 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017332
protein coding gene Chr1:186593762-186646078 (-)
PWK/PhJ MGP_PWKPhJ_G0016026
protein coding gene Chr1:179355333-179408492 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015802
protein coding gene Chr1:185553932-185605041 (-)
WSB/EiJ MGP_WSBEiJ_G0016301
protein coding gene Chr1:186787594-186841148 (-)



Homology
more
  • Human Ortholog
    CAPN2, calpain 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPN2, calpain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANP2, CANPL2, CANPml, mCANP
  • Links
    NCBI Gene ID: 824
    neXtProt AC: NX_P17655
    UniProt: P17655

  • Chr Location
    1q41; chr1:223701593-223776018 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1326
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CAPN2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12334 NCBI Gene Model | MGI Sequence Detail 50225 C57BL/6J ±  kb
    transcript NM_009794 RefSeq | MGI Sequence Detail 3330 C57BL/6  
    polypeptide O08529 UniProt | EBI | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 178
      cDNA 175
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1751, MGD-MRK-1755, MGI:2138213
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 11
      Gene Ontology 15
      Phenotypes 4
    • Earliest
      J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
    • Latest
      J:255903 Seinfeld J, et al., Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice. eNeuro. 2016 Jul-Aug;3(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory