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Capn2 Gene Detail
Summary
  • Symbol
    Capn2
  • Name
    calpain 2
  • Synonyms
    Capa2, Capa-2, m-calpain
  • Feature Type
    protein coding gene
  • IDs
    MGI:88264
    NCBI Gene: 12334
  • Gene Overview
    MyGene.info: CAPN2
Location & Maps
more
  • Sequence Map
    Chr1:182467260-182517608 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50349 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.93 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAPN2, calpain 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPN2, calpain 2
    Orthology source: HomoloGene
  • Synonyms
    CANP2, CANPL2, CANPml, mCANP
  • Links
    NCBI Gene ID: 824
    neXtProt AC: NX_P17655

  • Chr Location
    1q41-q42; chr1:223701593-223776018 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1326
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: CAPN2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050407 VEGA Gene Model | MGI Sequence Detail 50349 C57BL/6J ±  kb
transcript OTTMUST00000127918 VEGA | MGI Sequence Detail 3225 Not Applicable  
polypeptide OTTMUSP00000068918 VEGA | MGI Sequence Detail 700 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    917 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 177
    cDNA 174
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1751, MGD-MRK-1755, MGI:2138213
References
more
  • Summaries
    All 54
    Developmental Gene Expression 11
    Gene Ontology 12
    Phenotypes 3
  • Earliest
    J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
  • Latest
    J:207406 Piatkov KI, et al., Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E817-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory