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Capn2
Gene Detail
Symbol

Name
ID
Capn2
calpain 2
MGI:88264
Synonyms
Capa2, Capa-2, m-calpain
Feature Type
protein coding gene
Genetic Map
Chromosome 1
84.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:182467260-182517608 bp, - strand
From VEGA annotation of GRCm38

  50349 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1326  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CAPN2
Gene Tree: Capn2

Human
homologs
CAPN2, calpain 2, (m/II) large subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 824
neXtProt AC: NX_P17655

Human Synonyms: CANP2, CANPL2, CANPml, mCANP

Human Chr (Location): 1q41-q42; chr1:223701593-223776018 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure.
 
Interactions
Capn2 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process blastocyst development, cellular response to amino acid stimulus, ...
Component chromatin, cytoplasm, ...
Function calcium-dependent cysteine-type endopeptidase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (69)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 26
RNA in situ 12
Western blot 9
RT-PCR 22
cDNA source data(171)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase capn2.2 ; ZFIN capn2a, capn2b    NEW 
Molecular
reagents
All nucleic(177) cDNA(174) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050407 (Evidence)
Ensembl Gene Model ENSMUSG00000026509 (Evidence)
Entrez Gene 12334 (Evidence)
UniGene 19306
DFCI TC1571878, TC1702620
DoTS DT.97342626, DT.87072955, DT.110949256
EC 3.4.22.53
Consensus CDS Project CCDS35813.1
International Mouse Phenotyping Consortium Status Capn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050407 VEGA Gene Model | MGI Sequence Detail 50349 C57BL/6J ±  kb
transcript OTTMUST00000127918 VEGA | MGI Sequence Detail 3225 Not Applicable 
polypeptide OTTMUSP00000068918 VEGA | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(1016 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
InterPro IPR022683 Peptidase C2, calpain, domain III
InterPro IPR022684 Peptidase C2, calpain family
InterPro IPR022682 Peptidase C2, calpain, large subunit, domain III
Protein Ontology PR:000005015 calpain-2 catalytic subunit
References
(Earliest) J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
(Latest) J:207406 Piatkov KI, et al., Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E817-26
All references(56)
Other
accession IDs
MGD-MRK-1751, MGD-MRK-1755, MGI:2138213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory