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Capn2
Gene Detail
 Symbol
Name
ID
Capn2
calpain 2
MGI:88264
Synonyms Capa2, Capa-2, m-calpain
Feature Type protein coding gene
Genetic Map
Chromosome 1
84.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:182467259-182517483 bp, - strand
From NCBI annotation of GRCm38

  50225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1326  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Capn2

Human
homologs
Human Homolog CAPN2, calpain 2, (m/II) large subunit
NCBI Gene ID 824
neXtProt AC  NX_P17655
Human Synonyms  CANP2, CANPL2, CANPml, mCANP
Human Chr (Location)  1q41-q42; chr1:223701593-223776018 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure.
 
Interactions
Capn2 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process blastocyst development, cellular response to amino acid stimulus, ...
Component chromatin, cytoplasm, ...
Function calcium-dependent cysteine-type endopeptidase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (62)    Tissues (25)    Images (8)
Theiler Stages: 17, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 26
RNA in situ 12
Western blot 9
RT-PCR 15
cDNA source data(171)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(175) cDNA(174) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026509 (Evidence)
Entrez Gene12334 (Evidence)
UniGene19306
DFCITC1571878, TC1702620
DoTSDT.110949256, DT.87072955, DT.97342626
EC3.4.22.53
Consensus CDS ProjectCCDS35813.1
International Mouse Knockout Project StatusCapn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12334 NCBI Gene Model | MGI Sequence Detail 50225 C57BL/6J ±  kb
transcript NM_009794 RefSeq | MGI Sequence Detail 3205 C57BL/6 
polypeptide O08529 UniProt | EBI | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(1016 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
InterPro IPR022683 Peptidase C2, calpain, domain III
InterPro IPR022684 Peptidase C2, calpain family
InterPro IPR022682 Peptidase C2, calpain, large subunit, domain III
Protein Ontology PR:000005015 calpain-2 catalytic subunit
Graphical View of Protein Domain Structure
References (Earliest) J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(55)
Other
accession IDs
MGD-MRK-1751, MGD-MRK-1755, MGI:2138213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory