Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ASCL2
  • Mouse genes Ascl2
  • Rat genes Ascl2
  • Zfish genes ascl1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ascl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Ascl2	IDA		Rat	PMID:12196582|RGD:625617
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ASCL2	IDA		Human	PMID:14561729
Molecular Function	GO:0070888	E-box binding	ASCL2	IDA		Human	PMID:14561729
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ASCL2	IDA		Human	PMID:14561729
Molecular Function	GO:0043565	sequence-specific DNA binding	Ascl2	IDA		Mouse	PMID:9676199
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ASCL2	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	ASCL2	IDA		Human	PMID:12917334
Cellular Component	GO:0005737	cytoplasm	Ascl2	IDA		Mouse	PMID:23372768
Cellular Component	GO:0005634	nucleus	ASCL2	IDA		Human	PMID:11440538
Cellular Component	GO:0005634	nucleus	Ascl2	IDA		Mouse	PMID:19269367
Cellular Component	GO:0005634	nucleus	Ascl2	IDA		Mouse	PMID:23372768
Cellular Component	GO:0005634	nucleus	Ascl2	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Ascl2	IDA		Rat	PMID:12196582|RGD:625617
Biological Process	GO:0007420	brain development	ascl1b	IEP		Zfish	PMID:12524185
Biological Process	GO:0030154	cell differentiation	Ascl2	IMP	MGI:MGI:2153832	Mouse	PMID:8090202
Biological Process	GO:0043009	chordate embryonic development	ascl1b	IEP		Zfish	PMID:12524185
Biological Process	GO:0031018	endocrine pancreas development	ascl1b	IMP	ZFIN:ZDB-MRPHLNO-050308-14,ZFIN:ZDB-MRPHLNO-140811-4	Zfish	PMID:23835295
Biological Process	GO:0031018	endocrine pancreas development	ascl1b	IMP	ZFIN:ZDB-MRPHLNO-050308-14	Zfish	PMID:23835295
Biological Process	GO:0021575	hindbrain morphogenesis	ascl1b	IGI	ZFIN:ZDB-GENE-990415-174	Zfish	PMID:15659486|ZFIN:ZDB-PUB-050125-4
Biological Process	GO:0021575	hindbrain morphogenesis	ascl1b	IGI	ZFIN:ZDB-GENE-980526-90	Zfish	PMID:15659486|ZFIN:ZDB-PUB-050125-4
Biological Process	GO:0021575	hindbrain morphogenesis	ascl1b	IMP		Zfish	PMID:15659486|ZFIN:ZDB-PUB-050125-4
Biological Process	GO:0001701	in utero embryonic development	Ascl2	IMP	MGI:MGI:2153832	Mouse	PMID:8090202
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	Ascl2	IDA		Rat	PMID:12196582|RGD:625617
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ASCL2	IDA		Human	PMID:14561729
Biological Process	GO:0001890	placenta development	Ascl2	IMP	MGI:MGI:2155757	Mouse	PMID:21238448
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Ascl2	IDA		Mouse	PMID:19796622
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Ascl2	IGI	MGI:MGI:98510	Mouse	PMID:9676199
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Ascl2	IGI	MGI:MGI:98330	Mouse	PMID:9676199
Biological Process	GO:0001666	response to hypoxia	ASCL2	IEP		Human	PMID:14561729
Biological Process	GO:0035019	somatic stem cell population maintenance	Ascl2	IMP	MGI:MGI:3846671	Mouse	PMID:19269367
Biological Process	GO:0060708	spongiotrophoblast differentiation	Ascl2	IMP	MGI:MGI:2153832	Mouse	PMID:9331331
Biological Process	GO:0060712	spongiotrophoblast layer development	ASCL2	IEP		Human	PMID:12917334

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern