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Ascl2 Gene Detail
Summary
  • Symbol
    Ascl2
  • Name
    achaete-scute family bHLH transcription factor 2
  • Synonyms
    2410083I15Rik, bHLHa45, Mash2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96920
    NCBI Gene: 17173
  • Gene Overview
    MyGene.info: ASCL2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:142966829-142969264 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2436 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.08 cM
  • Mapping Data
    19 experiments
Homology
more
  • Human Ortholog
    ASCL2, achaete-scute family bHLH transcription factor 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ASCL2, achaete-scute family bHLH transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASH2, bHLHa45, HASH2, MASH2
  • Links
    NCBI Gene ID: 430
    neXtProt AC: NX_Q99929
    UniProt: Q99929

  • Chr Location
    11p15.5; chr11:2268498-2270952 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or heterozygous for a maternally inherited allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018799 VEGA Gene Model | MGI Sequence Detail 2436 C57BL/6J ±  kb
    transcript OTTMUST00000045263 VEGA | MGI Sequence Detail 1605 Not Applicable  
    polypeptide OTTMUSP00000020359 VEGA | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      228 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 71
      Genomic 30
      cDNA 18
      Primer pair 13
      Other 10

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12120, MGI:1920948
    References
    more
    • Summaries
      All 190
      Developmental Gene Expression 126
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:252754 Woods L, et al., Decidualisation and placentation defects are a major cause of age-related reproductive decline. Nat Commun. 2017 Sep 05;8(1):352

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory