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Ascl2 Gene Detail
Summary
  • Symbol
    Ascl2
  • Name
    achaete-scute family bHLH transcription factor 2
  • Synonyms
    2410083I15Rik, bHLHa45, Mash2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96920
    NCBI Gene: 17173
  • Gene Overview
    MyGene.info: ASCL2
Location & Maps
more
  • Sequence Map
    Chr7:142966829-142969264 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2436 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.08 cM
  • Mapping Data
    19 experiments
Homology
more
  • Human Ortholog
    ASCL2, achaete-scute family bHLH transcription factor 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ASCL2, achaete-scute family bHLH transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASH2, bHLHa45, HASH2, MASH2
  • Links
    NCBI Gene ID: 430
    neXtProt AC: NX_Q99929

  • Chr Location
    11p15.5; chr11:2268498-2270952 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Targeted
    9
  • Transgenic
    1
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele or heterozygous for a maternally inherited allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018799 VEGA Gene Model | MGI Sequence Detail 2436 C57BL/6J ±  kb
transcript OTTMUST00000045263 VEGA | MGI Sequence Detail 1605 Not Applicable  
polypeptide OTTMUSP00000020359 VEGA | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    228 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004363 achaete-scute homolog 2
  • InterPro Domains
    IPR015660 Achaete-scute transcription factor-related
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 69
    Genomic 30
    cDNA 17
    Primer pair 13
    Other 9

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12120, MGI:1920948
References
more
  • Summaries
    All 171
    Developmental Gene Expression 114
    Gene Ontology 12
    Phenotypes 17
  • Earliest
    J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
  • Latest
    J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 May 14;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory