Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADAMTS5
  • Mouse genes Adamts5
  • Rat genes Adamts5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adamts5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	Adamts5	IMP		Mouse	MGI:MGI:6508502|PMID:23233679
Molecular Function	GO:0050840	extracellular matrix binding	Adamts5	IDA		Mouse	PMID:24220035
Molecular Function	GO:0008201	heparin binding	Adamts5	IDA		Mouse	PMID:24220035
Molecular Function	GO:0042802	identical protein binding	ADAMTS5	IPI	UniProtKB:Q9UNA0	Human	PMID:26668318
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAMTS5	IDA		Human	PMID:25122765
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAMTS5	IDA		Human	PMID:26668318
Molecular Function	GO:0008237	metallopeptidase activity	ADAMTS5	IDA		Human	PMID:21370305
Molecular Function	GO:0008237	metallopeptidase activity	ADAMTS5	IDA		Human	PMID:33719441
Molecular Function	GO:0008237	metallopeptidase activity	Adamts5	IDA		Mouse	MGI:MGI:7327242|PMID:33719441
Molecular Function	GO:0008233	peptidase activity	ADAMTS5	IDA		Human	PMID:23845380
Molecular Function	GO:0005515	protein binding	ADAMTS5	IPI	UniProtKB:P13608	Human	PMID:22406378
Molecular Function	GO:0005515	protein binding	ADAMTS5	IPI	UniProtKB:P13611-2	Human	PMID:25122765
Molecular Function	GO:0005515	protein binding	ADAMTS5	IPI	UniProtKB:Q8WVF2	Human	PMID:29720262
Cellular Component	GO:0005615	extracellular space	Adamts5	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Adamts5	IDA		Mouse	PMID:24220035
Biological Process	GO:0003180	aortic valve morphogenesis	Adamts5	IMP		Mouse	MGI:MGI:5693221|PMID:23531444
Biological Process	GO:0042742	defense response to bacterium	Adamts5	IGI	MGI:MGI:1339949	Mouse	PMID:23684986
Biological Process	GO:0003203	endocardial cushion morphogenesis	Adamts5	IGI	UniProtKB:Q62432	Mouse	MGI:MGI:5693221|PMID:23531444
Biological Process	GO:0022617	extracellular matrix disassembly	Adamts5	IMP		Mouse	MGI:MGI:6508502|PMID:23233679
Biological Process	GO:0007520	myoblast fusion	Adamts5	IMP		Mouse	MGI:MGI:6508502|PMID:23233679
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Adamts5	IMP		Mouse	MGI:MGI:6162387|PMID:28702327
Biological Process	GO:0003184	pulmonary valve morphogenesis	Adamts5	IMP		Mouse	MGI:MGI:5693221|PMID:23531444
Biological Process	GO:0044691	tooth eruption	Adamts5	IEP		Rat	PMID:16200461|RGD:9684848

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern