Adamts5
Gene Detail

Symbol Name ID

Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) MGI:1346321

Synonyms

9530092O11Rik, ADAM-TS5

Feature Type

protein coding gene

Genetic Map

Chromosome 16

48.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:85858170-85901125 bp, - strand From Ensembl annotation of GRCm38   42956 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Adamts5 ± 2 cM)

Gene Tree: Adamts5

Human ortholog

ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 NCBI Gene ID 11096
Human Synonyms: ADAMTS11, ADAM-TS 11, ADAMTS-11, ADAM-TS5, ADAM-TS 5, ADAMTS-5, ADMP-2
Human Chr21:28290231-28339439 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(8) : Targeted(7) Gene trapped(1)
 

Mice homozygous for one null allele exhibit a significant reduction in cartilage degradation after induction of osteoarthritis whereas those homozygous for another show no affect.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	metabolic process, proteolysis
Component	extracellular matrix, extracellular region, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (377)    Tissues (274)    Images (113)
Theiler Stages: 10, 11, 13, 15, 17, 18, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	202
In situ reporter (knock in)	111
Northern blot	4
RT-PCR	60

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(21) Primer pair(5) Other(1)
Microarray probesets(10)

Other database links

Ensembl Gene Model	ENSMUSG00000022894 (Evidence)
Entrez Gene	23794 (Evidence)
DFCI	TC1584498, TC1598269, TC1618555
DoTS	DT.91284377
NIA Mouse Gene Index	U017330, U037244
EC	3.4.24.-
Consensus CDS Project	CCDS28288.1
International Mouse Knockout Project Status	Adamts5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022894	Ensembl Gene Model | MGI Sequence Detail	42956	C57BL/6J
transcript	ENSMUST00000023611	Ensembl | MGI Sequence Detail	8091	Not Applicable
polypeptide	ENSMUSP00000023611	Ensembl | MGI Sequence Detail	930	Not Applicable

All sequences(35) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(201 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010294	ADAM-TS Spacer 1
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR013273	Peptidase M12B, ADAM-TS
InterPro	IPR013276	Peptidase M12B, ADAM-TS5
InterPro	IPR002870	Peptidase M12B, propeptide
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000003734	A disintegrin and metalloproteinase with thrombospondin motifs 5

References

(Earliest) J:56831 Abbaszade I, et al., Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem. 1999 Aug 13;274(33):23443-50
(Latest) J:188489 Nissinen L, et al., ADAMTS5: A New Player in the Vascular Field. Am J Pathol. 2012 Sep;181(3):743-5
All references(60)

Other accession IDs

MGI:1925767, MGI:2146445