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Adamts5 Gene Detail
Summary
  • Symbol
    Adamts5
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
  • Synonyms
    9530092O11Rik, ADAM-TS5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346321
    NCBI Gene: 23794
  • Gene Overview
    MyGene.info: ADAMTS5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:85858170-85901125 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42956 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 48.34 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAMTS11, ADAM-TS 11, ADAMTS-11, ADAM-TS5, ADAM-TS 5, ADAMTS-5, ADMP-2
  • Links
    NCBI Gene ID: 11096
    neXtProt AC: NX_Q9UNA0
    UniProt: Q9UNA0

  • Chr Location
    21q21.3; chr21:26917912-26967120 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 6 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit a significant reduction in cartilage degradation after induction of osteoarthritis whereas those homozygous for another show no affect.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022894 Ensembl Gene Model | MGI Sequence Detail 42956 C57BL/6J ±  kb
    transcript ENSMUST00000023611 Ensembl | MGI Sequence Detail 8091 Not Applicable  
    polypeptide ENSMUSP00000023611 Ensembl | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      247 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 22
      Primer pair 5
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1925767, MGI:2146445
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 26
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:56831 Abbaszade I, et al., Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem. 1999 Aug 13;274(33):23443-50
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory