Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Semg1tm2Kemi mutation
(1 available);
any
Semg1 mutation
(30 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
Membrane disruption of intrauterine sperm in Semg1tm1Kemi/Semg1tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1tm2Kemi/Semg1tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
cellular
 |
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
|
reproductive system
|
|
• intrauterine death of sperm
|
|
|
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
|
|
|
• ejaculated sperm have already undergone the acrosomal reaction inside the uterus
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Semg1tm1Kemi mutation
(1 available);
any
Semg1 mutation
(30 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
Membrane disruption of intrauterine sperm in Semg1tm1Kemi/Semg1tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1tm2Kemi/Semg1tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
reproductive system
|
|
• intrauterine death of sperm
|
|
|
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
|
|
|
• ejaculated sperm have already undergone the acrosomal reaction inside the uterus
|
cellular
|
|
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrbptm1Tba mutation
(0 available);
any
Acrbp mutation
(19 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
reproductive system
|
|
• 6 h after mating with superovulated wild-type females, a significantly lower number of sperm is present in oviduct regions R1, R2, R3 and R7 (where R1 and R2 correspond to the lower isthmus and R7 corresponds to the ampulla) relative to controls
|
|
|
• 6 h after mating with superovulated wild-type females, fertilizing sperm present in oviduct region R7 (ampulla) shows a decreased number of sperm type-a (present on the oocyte zona pellucida [ZP] or already fertilized with the oocyte)
• no sperm containing EGFP in the acrosome is observed in R7, as observed in controls
|
|
|
• male subfertility may be due to incompleteness of the acrosome reaction rather than the reduced number of sperm migrated into the oviduct
|
|
|
• 6 h after mating with superovulated wild-type females, fertilizing sperm present in oviduct region R7 (ampulla) shows increased numbers of sperm type-b (localized within a 100-um distance from the zona pellucida [ZP]) and sperm type-c (present in the cumulus mass but absent within the 100-um distance from the ZP), indicating a reduction in the ability of sperm to recognize unfertilized oocytes in the cumulus mass
|
cellular
|
|
• 6 h after mating with superovulated wild-type females, a significantly lower number of sperm is present in oviduct regions R1, R2, R3 and R7 (where R1 and R2 correspond to the lower isthmus and R7 corresponds to the ampulla) relative to controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc9a8tm1d(KOMP)Wtsi mutation
(0 available);
any
Slc9a8 mutation
(108 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
reproductive system
|
|
• mature spermatozoa show abnormal mitochondrial distribution: mitochondria are found in sperm heads instead of forming a sheath around the initial part of the sperm tail
|
|
|
• mature spermatozoa isolated from the caudae epididymides lack acrosomes
|
cellular
|
|
• mature spermatozoa show abnormal mitochondrial distribution: mitochondria are found in sperm heads instead of forming a sheath around the initial part of the sperm tail
|
|
|
• mature spermatozoa isolated from the caudae epididymides lack acrosomes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcl2em1Ncvc mutation
(0 available);
any
Pdcl2 mutation
(21 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
reproductive system
|
|
• spermatozoa do not have clear and continuous signaling throughout the entire length of the flagellar midpiece, indicating an issue with flagella formation during spermatogenesis
|
cellular
|
|
• spermatozoa do not have clear and continuous signaling throughout the entire length of the flagellar midpiece, indicating an issue with flagella formation during spermatogenesis
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc23em1Mngx mutation
(0 available);
any
Lrrc23 mutation
(27 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
reproductive system
|
|
• in a uterotubal junction penetration assay, spermatozoa exhibit an inability to pass through the uterotubual junction
|
cellular
|
|
• in a uterotubal junction penetration assay, spermatozoa exhibit an inability to pass through the uterotubual junction
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Armc12em1Osb mutation
(2 available);
any
Armc12 mutation
(24 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
cellular
|
|
• sperm do not pass through the uterotubual junction
|
reproductive system
|
|
• sperm do not pass through the uterotubual junction
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nell2em1Osb mutation
(2 available);
any
Nell2 mutation
(45 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
cellular
reproductive system
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gk2em1Osb mutation
(2 available);
any
Gk2 mutation
(20 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation
(0 available)
|
|
|
reproductive system
|
|
• impaired passage of sperm through uterotubal junction
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
reproductive system
|
N |
|
Analysis Tools