Zdhhc19^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zdhhc19^em1Osb
• Name: zinc finger, DHHC domain containing 19; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:8221393
• Synonyms: Zdhhc19^-
• Gene: Zdhhc19 Location: Chr16:32315059-32326032 bp, + strand Genetic Position: Chr16, 22.76 cM
• Alliance: Zdhhc19^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR-targeting deleted 10,075 bp, as confirmed by Sanger sequencing. Immunoblot analysis demonstrated the absence of protein in the testes and cauda epididymal spermatozoa of homozygous mutant males. (J:366950)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc19 Mutation: 106 strains or lines available

References

• Original: J:366950 Kaneda Y, et al., TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2417943122
• All: 1 reference(s)