Fbxo24^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxo24^em1Osb
• Name: F-box protein 24; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:8347505
• Gene: Fbxo24 Location: Chr5:137610767-137623340 bp, - strand Genetic Position: Chr5, 76.59 cM, cytoband G1
• Alliance: Fbxo24^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9-mediated targeting deleted 11,575 bp to generate a null allele. The deletion was verified by Sanger sequencing. (J:366671)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo24 Mutation: 82 strains or lines available

References

• Original: J:366671 Kaneda Y, et al., FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility. Elife. 2024 Aug 20;13
• All: 1 reference(s)