Slc35g3^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc35g3^em1Osb
• Name: solute carrier family 35, member G3; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:8325060
• Gene: Slc35g3 Location: Chr11:69650710-69652670 bp, - strand Genetic Position: Chr11, 42.86 cM, cytoband B4
• Alliance: Slc35g3^em1Osb page

Mutation origin

• Strain of Origin: C57BL/6 x DBA/2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1804 bp deletion encompassing the entire coding region. Western blot analysis confirmed the absence of protein is testes and immunofluorescence confirmed absence in the Golgi. (J:383099)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc35g3 Mutation: 20 strains or lines available

References

• Original: J:383099 Mashiko D, et al., SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice. Elife. 2025 Nov 12;14
• All: 1 reference(s)