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Phenotype Image Detail
Image
Caption SVS2-mediated protection of intrauterine sperm from membrane disruption. (A) Transmission electron microscopic (TEM) images of sperm from Semg1tm1Kemi/Semg1tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1tm2Kemi/Semg1tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 mice. Diagram at far left indicates the orientation of sectioned heads of sperm. (Left) Sperm with SVS2; (Center) sperm with SVS2; (Right) sperm without SVS2. (Left, Center, and Right) Right upper and middle images are enlarged views of boxes in the left images, and diagrams are depicted in the right lower images. PM, plasma membrane; N, nucleus; NM, nuclear membrane. (Scale bars: 1 um.) (Center, Inset) A fluorescent image of the sperm reacted with anti-SVS2 pAb. (Scale bar, 5 um.)
Copyright This image is from Kawano N, Proc Natl Acad Sci U S A 2014 Mar 18;111(11):4145-50. Copyright 2014 National Academy of Sciences, U.S.A. J:207389
Associated
Alleles
Symbol Name
Semg1tm1Kemi semenogelin 1; targeted mutation 1, Kenji Miyado
Semg1tm2Kemi semenogelin 1; targeted mutation 2, Kenji Miyado
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb transgene insertion RBGS002, Research Institute for Microbial Diseases, Osaka University
Associated
Genotypes
Allelic Composition Genetic Background
Semg1tm1Kemi/Semg1tm1Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: 129 * C57BL/6 * C57BL/6N * DBA/2
Semg1tm2Kemi/Semg1tm2Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: 129 * C57BL/6 * C57BL/6N * DBA/2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory