Tex50^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tex50^em1Osb
• Name: testis expressed 50; endonuclease-mediated mutation 1, Osaka University
• MGI ID: MGI:8318857
• Gene: Tex50 Location: Chr1:160984413-160986883 bp, - strand Genetic Position: Chr1, 69.75 cM, cytoband H1
• Alliance: Tex50^em1Osb page

Mutation origin

• Strain of Origin: C57BL/6 x DBA/2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 2,315 bp deletion, including the 5' UTR, all of the protein-coding sequences in exons 1 and 2 and the intron. (J:382376)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tex50 Mutation: 6 strains or lines available

References

• Original: J:382376 Haga S, et al., Testis expressed 50 is essential for maintaining sperm acrosome integrity during epididymal transit. Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2507930122
• All: 1 reference(s)