About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tex50em1Osb
endonuclease-mediated mutation 1, Osaka University
MGI:8318857
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tex50em1Osb/Tex50em1Osb involves: C57BL/6 * DBA/2 MGI:8318860
cx2
 		Tex50em1Osb/Tex50em1Osb
Tg(CAG-EGFP,Acr-EGFP)2Osb/0 		involves: C57BL/6 * C57BL/6NSlc * DBA/2 MGI:8318861
cx3
 		Tex50em1Osb/Tex50em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6 * DBA/2 MGI:8318906


Genotype
MGI:8318860
hm1
Allelic
Composition		 Tex50em1Osb/Tex50em1Osb
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex50em1Osb mutation (0 available); any Tex50 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm flagellum morphology ( J:382376 )
• cauda epididymal spermatozoa exhibit malformation of the tail structure
• all cauda epididymal spermatozoa display irregular flagellar bending
coiled sperm flagellum ( J:382376 )
• cauda epididymal spermatozoa exhibit coiling of the sperm tail around the head
abnormal acrosome morphology ( J:382376 )
• cauda epididymal spermatozoa exhibit abnormal and underdeveloped acrosome
globozoospermia ( J:382376 )
• all cauda epididymal spermatozoa have abnormally shaped heads, missing the hook shape
asthenozoospermia ( J:382376 )
• spermatozoa are immotile
male infertility ( J:382376 )
• males are infertile, despite forming copulary plugs
• however, testicular weight and spermatogenesis are normal

cellular
abnormal sperm flagellum morphology ( J:382376 )
• cauda epididymal spermatozoa exhibit malformation of the tail structure
• all cauda epididymal spermatozoa display irregular flagellar bending
coiled sperm flagellum ( J:382376 )
• cauda epididymal spermatozoa exhibit coiling of the sperm tail around the head
abnormal acrosome morphology ( J:382376 )
• cauda epididymal spermatozoa exhibit abnormal and underdeveloped acrosome
globozoospermia ( J:382376 )
• all cauda epididymal spermatozoa have abnormally shaped heads, missing the hook shape
asthenozoospermia ( J:382376 )
• spermatozoa are immotile




Genotype
MGI:8318861
cx2
Allelic
Composition		 Tex50em1Osb/Tex50em1Osb
Tg(CAG-EGFP,Acr-EGFP)2Osb/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NSlc * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex50em1Osb mutation (0 available); any Tex50 mutation (6 available)
Tg(CAG-EGFP,Acr-EGFP)2Osb mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:382376 )
• massive abnormalities in epididymal spermatozoa, however no abnormalities in the testicular spermatozoa
• in both the round spermatid and testicular spermatozoa stages, no structural differences in spermiogenesis are seen
globozoospermia ( J:382376 )
• globozoospermia occurs after the testicular spermatozoa moves from the testis to the caput epididymis

cellular
teratozoospermia ( J:382376 )
• massive abnormalities in epididymal spermatozoa, however no abnormalities in the testicular spermatozoa
• in both the round spermatid and testicular spermatozoa stages, no structural differences in spermiogenesis are seen
globozoospermia ( J:382376 )
• globozoospermia occurs after the testicular spermatozoa moves from the testis to the caput epididymis




Genotype
MGI:8318906
cx3
Allelic
Composition		 Tex50em1Osb/Tex50em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex50em1Osb mutation (0 available); any Tex50 mutation (6 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm flagellum morphology ( J:382376 )
• cauda epididymal spermatozoa do not have proper flagella formation
• however, testicular spermatozoa have no visual abnormalities of the flagella
globozoospermia ( J:382376 )
• loss of the acrosome and sperm midpiece occurs between the migration of spermatozoa from the testes to the epididymis
absent acrosome ( J:382376 )
• acrosome is no longer present in cauda epididymal spermatozoa
• however, testicular spermatozoa have no visual abnormalities of the acrosome

cellular
abnormal sperm flagellum morphology ( J:382376 )
• cauda epididymal spermatozoa do not have proper flagella formation
• however, testicular spermatozoa have no visual abnormalities of the flagella
globozoospermia ( J:382376 )
• loss of the acrosome and sperm midpiece occurs between the migration of spermatozoa from the testes to the epididymis
absent acrosome ( J:382376 )
• acrosome is no longer present in cauda epididymal spermatozoa
• however, testicular spermatozoa have no visual abnormalities of the acrosome




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory