All Phenotypes Tg(Thy1-EGFP)MJrs MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Thy1-EGFP)MJrs
transgene insertion M, Joshua R Sanes
MGI:3766828

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cul3^tm1Jdsr/Cul3⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA	MGI:6449730
cn2	Cul3^tm1Jdsr/Cul3^tm1Jdsr Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA	MGI:6449726
cn3	Pten^tm1Hwu/Pten^tm1Hwu Tg(Camk2a-cre)T50Stl/0 Tg(Thy1-EGFP)MJrs/0	involves: 129S4/SvJae * BALB/c * C57BL/6J * CBA	MGI:4942301
cn4	Sh3rf1^em1Bcgen/Sh3rf1^em1Bcgen Tg(Nes-cre)1Kln/0 Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6 * CBA * SJL	MGI:7312058
cn5	Nae1^{tm1c(EUCOMM)Wtsi}/Nae1^{tm1c(EUCOMM)Wtsi} Tg(Camk2a-cre/ERT2)2Gsc/0 Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6J * C57BL/6N * CBA * FVB/N * SJL	MGI:6259522
cx6	Sema5a^tm1.2Alk/Sema5a^tm1.2Alk Sema5b^tm1.2Alk/Sema5b^tm1.2Alk Tg(Thy1-EGFP)MJrs/0	involves: 129 * BALB/cJ * C57BL/6 * CBA	MGI:5284892
cx7	Sema5b^tm1.2Alk/Sema5b^tm1.2Alk Tg(Thy1-EGFP)MJrs/0	involves: 129 * BALB/cJ * C57BL/6 * CBA	MGI:5284891
cx8	Gripap1^tm1Rlh/Gripap1^tm1Rlh Tg(Thy1-EGFP)MJrs/0	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:6158528
cx9	Dgcr8^Gt(XH157)Byg/Dgcr8⁺ Tg(Thy1-EGFP)MJrs/0	involves: 129P2/OlaHsd * C57BL/6J * CBA	MGI:3802829
cx10	Tmem59^tm1.1Tqw/Tmem59^tm1.1Tqw Tg(Thy1-EGFP)MJrs/0	involves: 129P2/OlaHsd * C57BL/6J * CBA	MGI:6158678
cx11	Dlgap4^Gt(XH723)Byg/Dlgap4^Gt(XH723)Byg Tg(Thy1-EGFP)MJrs/0	involves: 129P2/OlaHsd * C57BL/6J * CBA	MGI:6358594
cx12	Lnx1^tm1Henk/Lnx1^tm1Henk Tg(Thy1-EGFP)MJrs/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * CD-1	MGI:8228048
cx13	Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk Tg(Thy1-EGFP)MJrs/0	involves: 129S1/Sv * C57BL/6J * CBA * FVB/N	MGI:5297851
cx14	Tg(Thy1-EGFP)MJrs/0 Trim9^tm1.1Slgu/Trim9^tm1.1Slgu	involves: 129S4/SvJae * BALB/cJ * C57BL/6J * CBA	MGI:5660344
cx15	Spire1^{Gt(OST416113)Lex}/Spire1^{Gt(OST416113)Lex} Tg(Thy1-EGFP)MJrs/?	involves: 129S5/SvEvBrd * C57BL/6 * CBA	MGI:5699174
cx16	Sh3rf2^tm1Zhxu/Sh3rf2⁺ Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:6430624
cx17	Dpysl3^tm1Gosh/Dpysl3⁺ Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj	MGI:5751849
cx18	Dpysl3^tm1Gosh/Dpysl3^tm1Gosh Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj	MGI:5751847
cx19	Dnm1l^em1Hise/Dnm1l^em1Hise Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6J * CBA * SJL/J	MGI:6448493

Allelic Composition	Cul3^tm1Jdsr/Cul3⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3^tm1Jdsr mutation (1 available); any Cul3 mutation (51 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:292173 )

• fewer entries into and time spent in open arms in elevated plus maze test

• normal total distance travelled and time spent in closed arms in elevated plus maze test

increased thigmotaxis ( J:292173 )

• less time spent in center in open field test

• normal distance traveled in open field test

abnormal response to social novelty ( J:292173 )

• reduced social preference index when introduced to novel mouse and novel inanimate object in three-chamber test

• reduced social preference index when introduced to novel mouse and known mouse in three-chamber test

nervous system

nervous system phenotype ( J:292173 )

• normal cerebral cortex, corpus callosum and hippocampus morphology and brain weight

• normal neuron morphology in CA1 and hippocampal regions and in cerebral neocortex layers

• normal length and complexity of apical and basal dendrites of hippocampal CA1 neurons

• normal resting membrane potential (RMP) in hippocampal CA1 pyramidal neurons

increased dendritic spine density ( J:292173 )

• increased number of spines on apical dendrites of hippocampal CA1 neurons

increased miniature excitatory postsynaptic current frequency ( J:292173 )

• increased mEPSC frequency in hippocampal CA1 pyramidal neurons

increased miniature inhibitory postsynaptic current frequency ( J:292173 )

• increased mIPSC frequency in hippocampal CA1 pyramidal neurons

mortality/aging

mortality/aging ( J:292173 )

N	• viable and normal lifespan

growth/size/body

growth/size/body region phenotype ( J:292173 )

N	• normal body size

reproductive system

reproductive system phenotype ( J:292173 )

• fertile

Allelic Composition	Cul3^tm1Jdsr/Cul3^tm1Jdsr Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain weight ( J:292173 )

absent corpus callosum ( J:292173 )

abnormal hippocampus morphology ( J:292173 )

• deformed hippocampus

abnormal stratification in cerebral cortex ( J:292173 )

thin cerebral cortex ( J:292173 )

mortality/aging

preweaning lethality ( J:292173 )

• mice die before age P17

growth/size/body

decreased body size ( J:292173 )

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Tg(Camk2a-cre)T50Stl/0 Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Camk2a-cre)T50Stl mutation (0 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased brain size ( J:145970 )

• increase in brain size due to expansion of allocortex and neocortex

abnormal dendrite morphology ( J:145970 )

• apical dendrites of pyramidal neurons in cortical layer 2/3 but not layer 5 are longer and more tortuous than in controls

• total arbor length is on average 1.6 mm longer in mutants, indicating an approximate 80% expansion of the apical dendritic tree

• however, basal dendritic length is not different

• rapamycin treatments completely prevent dendritic growth seen following Pten deletion

Allelic Composition	Sh3rf1^em1Bcgen/Sh3rf1^em1Bcgen Tg(Nes-cre)1Kln/0 Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh3rf1^em1Bcgen mutation (0 available); any Sh3rf1 mutation (53 available)
Tg(Nes-cre)1Kln mutation (4 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased dendritic spine density ( J:326378 )

• reduction in the number and volume of mushroom, thin, and filopodium spines

• however, stubby spine numbers are normal

decreased dendritic spine length ( J:326378 )

• with reduced complexity

Allelic Composition	Nae1^{tm1c(EUCOMM)Wtsi}/Nae1^{tm1c(EUCOMM)Wtsi} Tg(Camk2a-cre/ERT2)2Gsc/0 Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nae1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Nae1 mutation (33 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:262411 )

N	• mice exhibit normal locomotion, sociability, fear conditioning and anxiety related behaviors

impaired long-term object recognition memory ( J:262411 )

• impaired in tamoxifen-treated mice

impaired short-term object recognition memory ( J:262411 )

• impaired in tamoxifen-treated mice

abnormal spatial working memory ( J:262411 )

• tamoxifen-treated mice exhibit impaired performance in a water-cross maze and Y-maze

nervous system

abnormal dendritic spine morphology ( J:262411 )

• reduced size in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice

• however, general neuron morphology is normal

decreased dendritic spine density ( J:262411 )

• in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice

abnormal CNS synaptic transmission ( J:262411 )

• reduced in tamoxifen-treated mice

• however, excitability is normal

Allelic Composition	Sema5a^tm1.2Alk/Sema5a^tm1.2Alk Sema5b^tm1.2Alk/Sema5b^tm1.2Alk Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema5a^tm1.2Alk mutation (1 available); any Sema5a mutation (67 available)
Sema5b^tm1.2Alk mutation (1 available); any Sema5b mutation (80 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:174679 )

• about 85% of labeled retinal ganglion cells have dendrites that arborize broadly within the inner plexiform layer, extending into the inner nuclear layer, outer plexiform layer, and, in a few cases, the outer nuclear layer

nervous system

abnormal dendrite morphology ( J:174679 )

abnormal retina ganglion cell morphology ( J:174679 )

Allelic Composition	Sema5b^tm1.2Alk/Sema5b^tm1.2Alk Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema5b^tm1.2Alk mutation (1 available); any Sema5b mutation (80 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:174679 )

• labeled retinal ganglion cells show mild dendritic arborization defects

nervous system

abnormal dendrite morphology ( J:174679 )

• labeled retinal ganglion cells show mild dendritic arborization defects

abnormal retina ganglion cell morphology ( J:174679 )

• labeled retinal ganglion cells show mild dendritic arborization defects

Allelic Composition	Gripap1^tm1Rlh/Gripap1^tm1Rlh Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gripap1^tm1Rlh mutation (1 available); any Gripap1 mutation (6 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal glutaminergic neuron morphology ( J:256043 )

• significant reduction in glutaminergic synapse density, as measured by number of spines on secondary dendrites of hippocampal CA1 neurons at age P21-23

Allelic Composition	Dgcr8^Gt(XH157)Byg/Dgcr8⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8^Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (67 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendrite morphology ( J:136969 )

• while length is normal, mushroom spine width in the CA1 pyramidal spines is decreased compared to in wild-type mice

• complexity of the basal dendritic tree of pyramidal neurons is reduced compared to in wild-type mice

Allelic Composition	Tmem59^tm1.1Tqw/Tmem59^tm1.1Tqw Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-EGFP)MJrs mutation (2 available)
Tmem59^tm1.1Tqw mutation (0 available); any Tmem59 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendrite morphology ( J:261729 )

• dendritic arborizations are much simpler in layer II/III of the cerebral cortex at P90

• total dendritic length is decreased by 27.8% and secondary and tertiary branching levels are significantly reduced

decreased dendritic spine density ( J:261729 )

• spine density is reduced by 15.6% on apical dendrites

• spine density in layer V/VI of the cortex is reduced at P42 and P90

• spine density in layer V/VI of the cortex remains relatively constant from P21 to P42 to P90 unlike in wild-type controls where spine density increases across these ages

Allelic Composition	Dlgap4^Gt(XH723)Byg/Dlgap4^Gt(XH723)Byg Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlgap4^Gt(XH723)Byg mutation (0 available); any Dlgap4 mutation (202 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendritic stubby spine morphology ( J:277713 )

• slight but significant decrease in the fraction of stubby spines but mean spine density remains unchanged

abnormal hippocampal pyramidal neuron dendrite morphology ( J:277713 )

• significant decrease in the mean total number of branching points and mean total path length of apical dendrites but not for basal dendrites

• significantly diminished mean number of apical dendritic intersections at 150 and 240 m distance from the soma

abnormal postsynaptic density morphology ( J:277713 )

• mean area covered by postsynaptic density is increased by 70% compared to wild-type controls

Allelic Composition	Lnx1^tm1Henk/Lnx1^tm1Henk Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lnx1^tm1Henk mutation (0 available); any Lnx1 mutation (43 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus CA3 region morphology ( J:267455 )

• increase in spine density but decrease in mushroom-shaped spines of CA3 neurons at 3 weeks of age

abnormal dendritic mushroom spine morphology ( J:267455 )

• increase in spine density but decrease in mushroom-shaped spines of CA3 neurons at 3 weeks of age

increased dendritic spine density ( J:267455 )

• increase in spine density but decrease in mushroom-shaped spines of CA3 neurons at 3 weeks of age

Allelic Composition	Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc7^tm1.1Mabk mutation (0 available); any Lrrc7 mutation (94 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendritic spine morphology ( J:177836 )

• the necks of dendritic spines exhibit decreased neck diameter compared to in wild-type mice

• the proportion of mushroom spines in increased while the number of stubby spines is decreased compared to in wild-type mice

• spine length on mushroom spines is increased compared to in wild-type mice

• however, the total number of spines is normal

Allelic Composition	Tg(Thy1-EGFP)MJrs/0 Trim9^tm1.1Slgu/Trim9^tm1.1Slgu
Genetic Background	involves: 129S4/SvJae * BALB/cJ * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-EGFP)MJrs mutation (2 available)
Trim9^tm1.1Slgu mutation (1 available); any Trim9 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:215804 )

• 4-fold increase in axon branching in the callosum

abnormal corpus callosum morphology ( J:215804 )

• 4-fold increase in axon branching in the callosum

increased corpus callosum size ( J:215804 )

• increased thickness

cellular

abnormal neuron differentiation ( J:215804 )

• 4-fold increase in axon branching in the callosum

Allelic Composition	Spire1^{Gt(OST416113)Lex}/Spire1^{Gt(OST416113)Lex} Tg(Thy1-EGFP)MJrs/?
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spire1^{Gt(OST416113)Lex} mutation (0 available); any Spire1 mutation (55 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendritic spine morphology ( J:226673 )

• reduction in number of dendritic spines on neurons from the entorhinal cortex

Allelic Composition	Sh3rf2^tm1Zhxu/Sh3rf2⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh3rf2^tm1Zhxu mutation (0 available); any Sh3rf2 mutation (54 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus morphology ( J:270945 )

• marker analysis indicates an asymmetric enrichment of NMDA and AMPA receptors in the left and right postsynaptic density of hippocampi

abnormal dendritic spine morphology ( J:270945 )

• mice show decreased spine volumes in secondary basal dendrites of left hippocampal CA1 pyramidal neurons, but not in right hemisphere CA1 pyramidal neurons; mushroom, stubby, and filopodia spines all show a decrease in spine volume

• volumes of mushroom, stubby, and filopdia spines are also decreased in apical dendrites of the left hippocampus, while only filopodia spine volumes are reduced in the right hippocampus

• hippocampal neurons from E18 mutants grown in culture show a decreased ratio of stubby spine but an increased ratio of filopodia spine in the secondary dendrites and decreased spine density and volume

increased dendritic spine density ( J:270945 )

• mice show an increased ratio of stubby spines but a decreased ratio of long thin spines in the bilateral hippocampus, indicating an increase in the density of mature spines

• however, no difference in spine density is seen in apical dendrites

abnormal hippocampal pyramidal neuron dendrite morphology ( J:270945 )

• CA1 pyramidal neurons show reduced secondary dendritic spine volume in the left hippocampus but not right hippocampus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:270945

Allelic Composition	Dpysl3^tm1Gosh/Dpysl3⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpysl3^tm1Gosh mutation (1 available); any Dpysl3 mutation (45 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased hippocampus pyramidal cell number ( J:226894 )

• type III CA1 pyramidal neurons

Allelic Composition	Dpysl3^tm1Gosh/Dpysl3^tm1Gosh Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpysl3^tm1Gosh mutation (1 available); any Dpysl3 mutation (45 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus pyramidal cell morphology ( J:226894 )

• CA1 pyramidal neurons bifurcate at the stratum pyramidale layer

decreased hippocampus pyramidal cell length ( J:226894 )

• in CA1 pyramidal neurons

increased hippocampus pyramidal cell number ( J:226894 )

• of type III CA1 pyramidal neurons

abnormal dendrite morphology ( J:226894 )

• cultured hippocampal neurons exhibit increased number of branching points compared with wild-type neurons

• neither number of branching points or total length is changed by Sema3A treatment unlike in wild-type cells

• however, dendrite length is normal

Allelic Composition	Dnm1l^em1Hise/Dnm1l^em1Hise Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: C57BL/6J * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1l^em1Hise mutation (0 available); any Dnm1l mutation (45 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neurite morphology ( J:291773 )

• increased number of neurites in CA1 and CA2 layers of dorsal hippocampus

abnormal dendritic spine morphology ( J:291773 )

• increased number of primary dendrites with dendritic spines in CA1 and CA2 layers of dorsal hippocampus

cellular

cellular phenotype ( J:291773 )

N	• normal mitochondrial morphology in in proximal and distal regions of hippocampal dendrites

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