Nae1tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Nae1tm1c(EUCOMM)Wtsi |
Name: |
NEDD8 activating enzyme E1 subunit 1; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6159278 |
Gene: |
Nae1 Location: Chr8:105237660-105261269 bp, - strand Genetic Position: Chr8, 53.04 cM
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Alliance: |
Nae1tm1c(EUCOMM)Wtsi page
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IMPC: |
Nae1 gene page |
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Mutant Cell Line: |
EPD0441_1_C08 |
Germline Transmission: |
Earliest citation of germline transmission:
J:261328
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Pgk_P
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Mutation details: Flp-mediated excision of the parental Nae1tm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and lacZ cassette leaving exon 4 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:261328)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nae1 Mutation: |
33 strains or lines available
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Original: |
J:261328 Zou J, et al., Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110 |
All: |
6 reference(s) |
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