Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nae1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Nae1 mutation
(33 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation
(1 available)
Tg(Thy1-EGFP)MJrs mutation
(1 available)
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behavior/neurological
N |
• mice exhibit normal locomotion, sociability, fear conditioning and anxiety related behaviors
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• impaired in tamoxifen-treated mice
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• impaired in tamoxifen-treated mice
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• tamoxifen-treated mice exhibit impaired performance in a water-cross maze and Y-maze
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nervous system
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• reduced size in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
• however, general neuron morphology is normal
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• in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
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• reduced in tamoxifen-treated mice
• however, excitability is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nae1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Nae1 mutation
(33 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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mortality/aging
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• expected or near expected numbers are found at E18.5 and P1 but no pups survive past P7 with most dying around 48-72 h after birth
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cardiovascular system
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• marked increase in the left ventricular noncompaction to compaction ratio at P1
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• increase in cardiomyocyte cross-sectional area
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• thicker trabecular layer in the left ventricle at E16.5
• at P1 prominent trabeculae that deeply penetrate into the compact layer are seen in both ventricles
• hypertrabeculation at P1
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• at P1 thinner in both left and right ventricles
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• thinner in the left ventricle at E16.5
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• impaired ventricular wall maturation
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• increase in heart to body weight ratio
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• left ventricular wall thinning at E18.5 and P1
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• marked increase in both left ventricle systolic and diastolic diameters and decrease in left ventricle systolic wall thickness at P1
• dilation is seen at E18.5
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• dilation is seen at E18.5
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• ejection fraction is reduced to 50% of controls
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homeostasis/metabolism
cellular
muscle
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• marked increase in the left ventricular noncompaction to compaction ratio at P1
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• increase in cardiomyocyte cross-sectional area
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• thicker trabecular layer in the left ventricle at E16.5
• at P1 prominent trabeculae that deeply penetrate into the compact layer are seen in both ventricles
• hypertrabeculation at P1
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• at P1 thinner in both left and right ventricles
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• thinner in the left ventricle at E16.5
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• ejection fraction is reduced to 50% of controls
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growth/size/body
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• increase in heart to body weight ratio
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