Spire1^{Gt(OST416113)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Spire1^{Gt(OST416113)Lex}
• Name: spire type actin nucleation factor 1; gene trap OST416113, Lexicon Genetics
• MGI ID: MGI:4310183
• Synonyms: spir-1^gt
• Gene: Spire1 Location: Chr18:67621279-67743860 bp, - strand Genetic Position: Chr18, 39.99 cM
• Alliance: Spire1^{Gt(OST416113)Lex} page

Mutation origin

• Mutant Cell Line: OST416113
• Germline Transmission: Earliest citation of germline transmission: J:226673
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene-trap vector inserted into the fifth predicted intron of the gene. This mutation disrupts the mRNA at sequences encoding a region immediately downstream of the N-terminal KIND domain. The absence of full-length encoded protein expression in homozygous mutant mice was confirmed by immunoblotting. (J:226673)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST416113	CG652623 ; (MGI Seq Detail)	3' RACE	Chr18:67652374-67663552 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  24 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spire1 Mutation: 55 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)