Phenotypes associated with this allele

• Allele Symbol: Spire1^{Gt(OST416113)Lex}
• Allele Name: gene trap OST416113, Lexicon Genetics
• Allele ID: MGI:4310183
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spire1^Gt(OST416113)Lex/Spire1^Gt(OST416113)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5699172
cx2	Spire1^Gt(OST416113)Lex/Spire1^Gt(OST416113)Lex Tg(Thy1-EGFP)MJrs/?	involves: 129S5/SvEvBrd * C57BL/6 * CBA	MGI:5699174

Genotype
MGI:5699172

hm1

• Allelic Composition: Spire1^{Gt(OST416113)Lex}/Spire1^{Gt(OST416113)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:226673 )

N • normal behavior on a rotarod and in a water maze

enhanced contextual conditioning behavior ( J:226673 )

♂ • males only display a significant increase in fear memory after a thermal nociception test

enhanced cued conditioning behavior ( J:226673 )

♂ • males only display a significant increase in fear memory after a thermal nociception test

nervous system

nervous system phenotype ( J:226673 )

N • no obvious structural alterations in brain

reproductive system

reproductive system phenotype ( J:226673 )

N • homozygotes are born in expected Mendelian ratios and are viable

N • male and female fertility are normal

skeleton

skeleton phenotype ( J:226673 )

N • no obvious abnormalities of skeleton or other organ systems

integument

integument phenotype ( J:226673 )

N • no obvious skin abnormalities

vision/eye

vision/eye phenotype ( J:226673 )

N • visual acuity is normal

growth/size/body

growth/size/body region phenotype ( J:226673 )

N • normal growth and body weight at 5-8 weeks of age

Genotype
MGI:5699174

cx2

• Allelic Composition: Spire1^{Gt(OST416113)Lex}/Spire1^{Gt(OST416113)Lex}; Tg(Thy1-EGFP)MJrs/?
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CBA

nervous system

abnormal dendritic spine morphology ( J:226673 )

• reduction in number of dendritic spines on neurons from the entorhinal cortex