Lnx1^tm1Henk
Targeted Allele Detail

Summary

• Symbol: Lnx1^tm1Henk
• Name: ligand of numb-protein X 1; targeted mutation 1, Mark Henkemeyer
• MGI ID: MGI:8228037
• Gene: Lnx1 Location: Chr5:74753108-74863573 bp, - strand Genetic Position: Chr5, 39.52 cM, cytoband D
• Alliance: Lnx1^tm1Henk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267455
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The start sites and initial coding exons for both the p80 and p70 isoforms were replaced with a lacZ gene and floxed neo cassette via homologous recombination. Beta-gal expression was detected in multiple tissues in embryos including, eyes, ears, and limbs. (J:267455)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lnx1 Mutation: 43 strains or lines available

References

• Original: J:267455 Liu XD, et al., Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1. J Cell Biol. 2018 Nov 5;217(11):4007-4024
• All: 1 reference(s)