All Phenotypes Bax<tm2Sjk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bax^tm2Sjk
targeted mutation 2, Stanley J Korsmeyer
MGI:3589203

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3608659
cn2	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3608663
cn3	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Kras^tm4Tyj/Kras⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5559061
cn4	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)#Mam/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB	MGI:3819938
cn5	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm2Sjk/Bax^tm2Sjk Tg(Lck-cre)548Jxm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5562713
cn6	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm2Sjk/Bax^tm2Sjk Tg(Lck-cre)1Cwi/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5691376
cn7	Bax^tm2Sjk/Bax^tm2Sjk Scyl2^tm1.1Spel/Scyl2^tm1.1Spel Tg(Nes-cre)1Kln/0	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL	MGI:5752574
cn8	Vdac2^tm1.1Ehyc/Vdac2^tm1.1Ehyc Bax^tm2Sjk/Bax^tm2Sjk Tg(Lck-cre)1Cwi/?	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:5691375

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (23 available)
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased pro-B cell number ( J:100463 )

• 4-fold increase in the number of CD43⁺IgM^- Pro-B cells

abnormal B cell number ( J:100463 )

decreased marginal zone B cell number ( J:100463 )

• relative number of CD21^highCD23^low marginal zone B cells is decreased

increased B cell number ( J:100463 )

• increase in the number of B cells at all stages of development in the bone marrow and spleen

increased transitional stage B cell number ( J:100463 )

• a 3-5 fold increase in the numbers of transitional B cells

increased B-2 B cell number ( J:100463 )

• an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity

increased follicular B cell number ( J:100463 )

• an increase in CD21^intCD23^high follicular B cells

increased pre-B cell number ( J:100463 )

• a 4-fold increase in the number of IgM⁺ immature B cells

abnormal B cell physiology ( J:100463 )

• B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage

• cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA

increased immunoglobulin level ( J:100463 )

• all isotypes were 5-10 times higher than controls

increased IgA level ( J:100463 )

increased IgG level ( J:100463 )

• increased IgG1, IgG2, IgG2b and IgG3

increased IgM level ( J:100463 )

hematopoietic system

increased pro-B cell number ( J:100463 )

• 4-fold increase in the number of CD43⁺IgM^- Pro-B cells

increased bone marrow cell number ( J:100463 )

• 2-fold increase in total cellularity of bone marrow cells, due to accumulation of developing B cells

abnormal B cell number ( J:100463 )

decreased marginal zone B cell number ( J:100463 )

• relative number of CD21^highCD23^low marginal zone B cells is decreased

increased B cell number ( J:100463 )

• increase in the number of B cells at all stages of development in the bone marrow and spleen

increased transitional stage B cell number ( J:100463 )

• a 3-5 fold increase in the numbers of transitional B cells

increased B-2 B cell number ( J:100463 )

• an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity

increased follicular B cell number ( J:100463 )

• an increase in CD21^intCD23^high follicular B cells

increased pre-B cell number ( J:100463 )

• a 4-fold increase in the number of IgM⁺ immature B cells

abnormal B cell physiology ( J:100463 )

• B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage

• cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA

increased immunoglobulin level ( J:100463 )

• all isotypes were 5-10 times higher than controls

increased IgA level ( J:100463 )

increased IgG level ( J:100463 )

• increased IgG1, IgG2, IgG2b and IgG3

increased IgM level ( J:100463 )

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:100463 )

• by 35 weeks after induction of Cre expression (and thus Bax deletion) in the adult, 78% of mutants die compared to 5% of wild-type

immune system

abnormal T cell differentiation ( J:100463 )

• thymic T cell development is perturbed after poly(I:C) injection

increased leukocyte cell number ( J:100463 )

• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult

increased lymphocyte cell number ( J:100463 )

increased B cell number ( J:100463 )

• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression

increased susceptibility to autoimmune disorder ( J:100463 )

• develop autoimmune disease after poly(I:C) injection to induce Bax deletion in the adult

increased anti-double stranded DNA antibody level ( J:100463 )

• show elevated serum antinuclear antibodies and anti-dsDNA antibody after 30 weeks of poly(I:C) injection to induce Bax deletion in the adult

arthritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

glomerulonephritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

hematopoietic system

abnormal T cell differentiation ( J:100463 )

• thymic T cell development is perturbed after poly(I:C) injection

increased leukocyte cell number ( J:100463 )

• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult

increased lymphocyte cell number ( J:100463 )

increased B cell number ( J:100463 )

• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression

renal/urinary system

glomerulonephritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

skeleton

arthritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Kras^tm4Tyj/Kras⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (23 available)
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased adenocarcinoma incidence ( J:125101 )

• intranasal instillation of an adenovirus expressing Cre recombinase (Ad-Cre) results in the development of sinonasal adenocarcinomas

• however, mice injected intramuscularly with Ad-Cre into the extremities or uterus do not develop soft tissue sarcomas

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (23 available)
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1^tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(MMTV-cre)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:141545 )

N	• unlike in Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)Mam mice or Bnip3l^tm1Ney homozygotes, spleen size, red blood cell numbers and reticulocytes clear of mitochondria are normal

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm2Sjk/Bax^tm2Sjk Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (23 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased regulatory T cell number ( J:208318 )

• at 15 months as in Bcl2l11^tm1.1Ast homozygotes

hematopoietic system

increased regulatory T cell number ( J:208318 )

• at 15 months as in Bcl2l11^tm1.1Ast homozygotes

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm2Sjk/Bax^tm2Sjk Tg(Lck-cre)1Cwi/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:220951 )

• completely resistant to apoptosis

cellular

decreased thymocyte apoptosis ( J:220951 )

• completely resistant to apoptosis

hematopoietic system

decreased thymocyte apoptosis ( J:220951 )

• completely resistant to apoptosis

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:220951 )

• completely resistant to apoptosis

Allelic Composition	Bax^tm2Sjk/Bax^tm2Sjk Scyl2^tm1.1Spel/Scyl2^tm1.1Spel Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Scyl2^tm1.1Spel mutation (0 available); any Scyl2 mutation (37 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:225808 )

• fewer than expected mice are present at weaning

growth/size/body

decreased body size ( J:225808 )

behavior/neurological

behavior/neurological phenotype ( J:225808 )

N	• mice do not exhibit limb clasping as in Scyl2^tm1.1Spel/Scyl2^tm1.1Spel Tg(Nes-cre)1Kln mice

nervous system

nervous system phenotype ( J:225808 )

N	• mice exhibit nor brain abnormalities unlike in Scyl2^tm1.1Spel/Scyl2^tm1.1Spel Tg(Nes-cre)1Kln mice

Allelic Composition	Vdac2^tm1.1Ehyc/Vdac2^tm1.1Ehyc Bax^tm2Sjk/Bax^tm2Sjk Tg(Lck-cre)1Cwi/?
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2^tm1.1Ehyc mutation (0 available); any Vdac2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:220951 )

decreased thymocyte number ( J:220951 )

• two fold reduction of thymocytes although the developmental profile seems normal

hematopoietic system

small thymus ( J:220951 )

decreased thymocyte number ( J:220951 )

• two fold reduction of thymocytes although the developmental profile seems normal

endocrine/exocrine glands

small thymus ( J:220951 )

decreased thymocyte number ( J:220951 )

• two fold reduction of thymocytes although the developmental profile seems normal

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