Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Bgeo/ALPP)1Lbe
• Allele Name: transgene insertion 1, Corrinne Lobe
• Allele ID: MGI:3505556
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm1Hwu/Pten^tm1Hwu Tg(CAG-Bgeo/ALPP)1Lbe/0 Tg(Cela1-cre/ERT)1Dam/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4836240
cn2	Tg(CAG-Bgeo/ALPP)1Lbe/0 Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0 Tg(Hoxb3-cre)1Pkht/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5749827
cn3	Tg(CAG-Bgeo/ALPP)1Lbe/0 Tg(Ins2-cre/ERT)1Dam/0 Tg(Ins2-rtTA)2Efr/0 Tg(tetO-DTA)1Gfi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3770687
cn4	Opn4^tm1.1(cre)Saha/Opn4^+ Pou4f2^tm4(DTA)Whk/Pou4f2^+ Tg(CAG-Bgeo/ALPP)1Lbe/0	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5285913
cx5	Npr2^tm2.1(cre/ERT2)Fgr/Npr2^cn Tg(CAG-Bgeo/ALPP)1Lbe/0	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J	MGI:5568088
tg6	Tg(CAG-Bgeo/ALPP)1Lbe/Tg(CAG-Bgeo/ALPP)1Lbe	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:3803740

Genotype
MGI:4836240

cn1

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(CAG-Bgeo/ALPP)1Lbe/0; Tg(Cela1-cre/ERT)1Dam/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:102226 )

N • 4 weeks after tamoxifen injections to induce Cre expression, pancreata exhibit no ductal metaplasia

Genotype
MGI:5749827

cn2

• Allelic Composition: Tg(CAG-Bgeo/ALPP)1Lbe/0; Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0; Tg(Hoxb3-cre)1Pkht/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

embryo

abnormal enteric neural crest cell migration ( J:136122 )

• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine

cellular

abnormal enteric neural crest cell migration ( J:136122 )

• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine

Genotype
MGI:3770687

cn3

• Allelic Composition: Tg(CAG-Bgeo/ALPP)1Lbe/0; Tg(Ins2-cre/ERT)1Dam/0; Tg(Ins2-rtTA)2Efr/0; Tg(tetO-DTA)1Gfi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

endocrine/exocrine glands

increased pancreatic beta cell number ( J:127412 )

• tamoxifen injections during last 10 days of doxycycline treatment labels surviving beta cells with human placental alkaline phosphatase; labeling results indicate that majority or all regenerated beta cells are derived from surviving beta cells, rather than from non-beta cells or stem cells

homeostasis/metabolism

hyperglycemia ( J:127412 )

• treatment of newborn mice with doxycycline for 45 days results in diabetes development

Genotype
MGI:5285913

cn4

• Allelic Composition: Opn4^{tm1.1(cre)Saha}/Opn4⁺; Pou4f2^tm4(DTA)Whk/Pou4f2⁺; Tg(CAG-Bgeo/ALPP)1Lbe/0
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

abnormal olivary pretectal nucleus morphology ( J:174940 )

• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls

abnormal innervation ( J:174940 )

• innervation of the intergeniculate leaflet (IGL) is markedly reduced

decreased retina ganglion cell number ( J:174940 )

• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ Opn4^{tm1.1(cre)Saha/+} animals

vision/eye

decreased retina ganglion cell number ( J:174940 )

• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ Opn4^{tm1.1(cre)Saha/+} animals

Genotype
MGI:5568088

cx5

• Allelic Composition: Npr2^{tm2.1(cre/ERT2)Fgr}/Npr2^cn; Tg(CAG-Bgeo/ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J

nervous system

nervous system phenotype ( J:205571 )

N • at E15.5 formation of collaterals by cranial sensory axons is not affected by Npr2 deficiency

N • peripheral processes of the ophthalmic branch of the trigeminal nerve are not significantly affected by Npr2 deficiency

abnormal cranial nerve morphology ( J:205571 )

• at E12.5 axons from cranial sensory ganglia do not bifurcate at the entry zone to the brainstem

abnormal dorsal root ganglion morphology ( J:205571 )

• mice lack axon bifurcation of DRG neurons; axons only exhibit only turns with Npr2 deficiency

Genotype
MGI:3803740

tg6

• Allelic Composition: Tg(CAG-Bgeo/ALPP)1Lbe/Tg(CAG-Bgeo/ALPP)1Lbe
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

mortality/aging

prenatal lethality, complete penetrance ( J:62916 )

• homozygotes are not viable; line is maintained and used in hemizygous state