Tg(Ins2-rtTA)2Efr
Transgene Detail

Summary

• Symbol: Tg(Ins2-rtTA)2Efr
• Name: transgene insertion 2, Shimon Efrat
• MGI ID: MGI:3770667
• Synonyms: Ins-rtTA, RIP7-rtTA, RiprtTA
• Transgene: Tg(Ins2-rtTA)2Efr Location: unknown
• Alliance: Tg(Ins2-rtTA)2Efr page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: A transgenic construct containing 9.5kb 5' regulatory sequence and first intron of the rat insulin 2 gene (RIP7) controlling the reverse tetracycline transactivator (rtTA), as well as the polyadenylation site sequence of the RIP7 gene was injected into fertilized (C57BL/6 X CBA)F2 mouse eggs. Founder line 2 with 10 copies of the transgene was established. When mice are crossed to transgenic mice carrying reporter genes, transgene expression is detected only in pancreatic islet beta cells. (J:130049)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:130049 Milo-Landesman D, et al., Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system. Cell Transplant. 2001;10(7):645-50
• All: 36 reference(s)