Npr2tm2.1(cre/ERT2)Fgr
Targeted Allele Detail
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Symbol: |
Npr2tm2.1(cre/ERT2)Fgr |
Name: |
natriuretic peptide receptor 2; targeted mutation 2.1, Fritz G Rathjen |
MGI ID: |
MGI:5567995 |
Synonyms: |
Npr2-CreERT2 |
Gene: |
Npr2 Location: Chr4:43631935-43651244 bp, + strand Genetic Position: Chr4, 23.05 cM
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Alliance: |
Npr2tm2.1(cre/ERT2)Fgr page
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Npr2tm2.1(cre/ERT2)Fgr expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Npr2 (MGI:97372) |
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Mutation details: A targeting construct was used to replace exon 1 of the Npr2 gene with the sequence for a tamoxifen- inducible cre recombinase (cre/ERT2) followed by a polyadenylation signal and an frt-flanked neo selection marker, by homologous recombination in ES cells. The neo marker was deleted by crossbreeding with Flp-expressing mice.
(J:205571)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Npr2
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Npr2 Mutation: |
61 strains or lines available
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Original: |
J:205571 Ter-Avetisyan G, et al., Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling. J Neurosci. 2014 Jan 15;34(3):737-47 |
All: |
4 reference(s) |
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