All Phenotypes Cdkn1b<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdkn1b⁺
wild type
MGI:3053659

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cdkn1b^tm1Mlf/Cdkn1b⁺	involves: 129S4/SvJaeSor	MGI:3611804
ht2	Cdkn1b^tm3Jro/Cdkn1b⁺	involves: 129S4/SvJaeSor	MGI:3613028
ht3	Cdkn1b^tm1Mlf/Cdkn1b⁺	involves: 129S4/SvJaeSor * C57BL/6NHsd	MGI:3719055
cn4	Cdkn1b^tm1Ako/Cdkn1b⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(TPO-cre)1Shk/0	129S1.Cg-Cdkn1b^tm1Ako Tg(TPO-cre)1Shk Pten^tm2.1Ppp	MGI:4838319
cn5	Cdkn1b^tm1Mlf/Cdkn1b⁺ Crebbp^tm1Jvd/Crebbp^tm1Jvd Tg(MMTV-cre)4Mam/0	involves: 129 * C57BL/6 * CBA * FVB	MGI:3618584
cx6	Cdkn1b^tm1Mlf/Cdkn1b⁺ Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129 * C57BL/6	MGI:5449369
cx7	Cdkn1b^tm1Mlf/Cdkn1b⁺ Myc^tm1Atp/Myc⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:3811822
cx8	Cdkn1b^tm1Mlf/Cdkn1b⁺ Ptch1^tm1Mps/Ptch1⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5544754
cx9	Cdkn1b^tm1Kin/Cdkn1b⁺ Irs2^tm1Mfw/Irs2^tm1Mfw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3529771
cx10	Cdkn1b^tm1Ako/Cdkn1b⁺ Kit^W-v/Kit^W-v	involves: 129S1/Sv * C57BL/6J	MGI:5811261
cx11	Cdkn1b^tm1Mlf/Cdkn1b⁺ Tg(TG-TPR/NTRK1)#Rstn/0	involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J	MGI:5581427
cx12	Cdkn1b^tm1Kin/Cdkn1b⁺ Lepr^db/Lepr^db	involves: C57BL/6J * C57BLKS/J	MGI:3529778

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:103819 )

• similar increase in the incidence of urethane-induced lung tumors as homozygotes, with more large tumors than in wild-type

• increased incidence of liver hemangiomas, uterine tumors, and ovarian granulose cell tumors after 20 weeks of urethane treatment, but less than in homozygotes

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:103819 )

• similar increase in the incidence of urethane-induced lung tumors as homozygotes, with more large tumors than in wild-type

• increased incidence of liver hemangiomas, uterine tumors, and ovarian granulose cell tumors after 20 weeks of urethane treatment, but less than in homozygotes

Allelic Composition	Cdkn1b^tm3Jro/Cdkn1b⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm3Jro mutation (0 available); any Cdkn1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body size ( J:103819 )

• larger than wild-type but smaller than homozygotes

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased cochlear inner hair cell number ( J:53290 )

• at P6, heterozygotes display occasional supernumerary inner hair cells throughout the organ of Corti; never observed in wild-type mice

• in contrast, the heterozygous outer hair cell population remains normal relative to wild-type mice

nervous system

increased cochlear inner hair cell number ( J:53290 )

• at P6, heterozygotes display occasional supernumerary inner hair cells throughout the organ of Corti; never observed in wild-type mice

• in contrast, the heterozygous outer hair cell population remains normal relative to wild-type mice

Allelic Composition	Cdkn1b^tm1Ako/Cdkn1b⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(TPO-cre)1Shk/0
Genetic Background	129S1.Cg-Cdkn1b^tm1Ako Tg(TPO-cre)1Shk Pten^tm2.1Ppp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Ako mutation (0 available); any Cdkn1b mutation (26 available)
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (86 available)
Tg(TPO-cre)1Shk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:165293 )

• mean survival is 58 weeks of age

neoplasm

increased thyroid adenoma incidence ( J:165293 )

• no sex differences in development of adenomas

increased thyroid carcinoma incidence ( J:165293 )

• no sex differences in development of carcinomas

endocrine/exocrine glands

increased thyroid adenoma incidence ( J:165293 )

• no sex differences in development of adenomas

increased thyroid carcinoma incidence ( J:165293 )

• no sex differences in development of carcinomas

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Crebbp^tm1Jvd/Crebbp^tm1Jvd Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Crebbp^tm1Jvd mutation (2 available); any Crebbp mutation (100 available)
Tg(MMTV-cre)4Mam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:88323 )

• considerably accelerated tumor development

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:88323 )

• considerably accelerated tumor development

hematopoietic system

increased T cell derived lymphoma incidence ( J:88323 )

• considerably accelerated tumor development

immune system

increased T cell derived lymphoma incidence ( J:88323 )

• considerably accelerated tumor development

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Vsx2^tm1.1Eml/Vsx2^tm1.1Eml
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Vsx2^tm1.1Eml mutation (0 available); any Vsx2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:190452 )

• substantial improvements in tissue histology and retinal neurogenesis compared to mice homozygous for Vsx2^tm1.1Eml alone

• rescue in the peripheral region is not as strong as in the central region

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Myc^tm1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Myc^tm1Atp mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:73369 )

• as in Myc^tm1Atp heterozygotes

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Ptch1^tm1Mps/Ptch1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Ptch1^tm1Mps mutation (2 available); any Ptch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205254 )

• median survival of mutants that only develop medulloblastoma is 127 days

neoplasm

increased tumor incidence ( J:205254 )

• 11.8% of mutants develop other tumors, including hemangiosarcomas, intestinal tumors, rhabdomyosarcomas, and lymphomas

increased gastrointestinal tumor incidence ( J:205254 )

increased rhabdomyosarcoma incidence ( J:205254 )

increased lymphoma incidence ( J:205254 )

increased medulloblastoma incidence ( J:205254 )

• 59.7% of mutants develop medulloblastoma

• medulloblastomas are less differentiated and more invasive than medulloblastomas from single Ptch1 heterozygotes, sometimes penetrating the white matter and sometimes obliterating the normal contours of the cerebellar lobes

increased hemangiosarcoma incidence ( J:205254 )

nervous system

increased medulloblastoma incidence ( J:205254 )

• 59.7% of mutants develop medulloblastoma

hydrocephaly ( J:205254 )

• fraction of mutants develop hydrocephalus unrelated to tumor formation

abnormal cerebellar molecular layer ( J:205254 )

• 1 month old cerebella show preneoplastic lesions in the outer molecular layer where progenitors within the external germinal layer previously resided, suggesting that medulloblastomas arise from granule neuron progenitors

muscle

increased rhabdomyosarcoma incidence ( J:205254 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:205254 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:205254

Allelic Composition	Cdkn1b^tm1Kin/Cdkn1b⁺ Irs2^tm1Mfw/Irs2^tm1Mfw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Kin mutation (1 available); any Cdkn1b mutation (26 available)
Irs2^tm1Mfw mutation (1 available); any Irs2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell number ( J:96047 )

• beta cell proliferation and the total number of beta cells are increased compared to Irs2 single homozygotes; however the size of individual beta cells is similar to Irs2 single homozygotes

enlarged pancreatic islets ( J:96047 )

• islet mass, but not islet density, is significantly increased compared to Irs2 single homozygotes

homeostasis/metabolism

increased circulating glucose level ( J:96047 )

• compound mutants have significantly elevated blood glucose levels at 18 weeks; however this elevation is slight compared to Irs2 single homozygotes

increased circulating insulin level ( J:96047 )

• fasting serum insulin levels are increased

Allelic Composition	Cdkn1b^tm1Ako/Cdkn1b⁺ Kit^W-v/Kit^W-v
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Ako mutation (0 available); any Cdkn1b mutation (26 available)
Kit^W-v mutation (9 available); any Kit mutation (177 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:236161 )

• sudden death is frequently seen

neoplasm

increased ovary tumor incidence ( J:236161 )

• mice exhibit enlarged ovarian tumors compared to single Kit homozygous mutants

• in aged mice, large ovarian tumors develop, infiltrate, and occupy the entire para- and meso-ovarian regions

increased ovary adenoma incidence ( J:236161 )

• ovarian tubular adenomas are bilateral

• ovaries have a tumor phenotype that is more prominent than the tubular adenomas of the double homozygous ovaries

• papillary ovarian tubular adenomas from 8 month old mice have CK8+ epithelial cells infiltrating the entire ovary, the bursa and surrounding areas and resemble ovarian cancer or severe ovarian surface papillomatosis

• however, the epithelial lesions of ovarian tumors are benign

• tumor mass is largely epithelial and contains a minor 10% of less of granulosa cells

endocrine/exocrine glands

increased ovary tumor incidence ( J:236161 )

• mice exhibit enlarged ovarian tumors compared to single Kit homozygous mutants

• in aged mice, large ovarian tumors develop, infiltrate, and occupy the entire para- and meso-ovarian regions

increased ovary adenoma incidence ( J:236161 )

• ovarian tubular adenomas are bilateral

• ovaries have a tumor phenotype that is more prominent than the tubular adenomas of the double homozygous ovaries

• however, the epithelial lesions of ovarian tumors are benign

• tumor mass is largely epithelial and contains a minor 10% of less of granulosa cells

abnormal ovary physiology ( J:236161 )

• ovarian epithelial cells show enhanced cell proliferation in culture compared to single homozygous Kit mutants

reproductive system

increased ovary tumor incidence ( J:236161 )

• mice exhibit enlarged ovarian tumors compared to single Kit homozygous mutants

• in aged mice, large ovarian tumors develop, infiltrate, and occupy the entire para- and meso-ovarian regions

increased ovary adenoma incidence ( J:236161 )

• ovarian tubular adenomas are bilateral

• ovaries have a tumor phenotype that is more prominent than the tubular adenomas of the double homozygous ovaries

• however, the epithelial lesions of ovarian tumors are benign

• tumor mass is largely epithelial and contains a minor 10% of less of granulosa cells

abnormal ovary physiology ( J:236161 )

• ovarian epithelial cells show enhanced cell proliferation in culture compared to single homozygous Kit mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:236161

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Tg(TG-TPR/NTRK1)#Rstn/0
Genetic Background	involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Tg(TG-TPR/NTRK1)#Rstn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased thyroid carcinoma incidence ( J:210015 )

• total number of papillary thyroid carcinomas that form is higher than in single Tg(TG-TPR/NTRK1)#Rstn transgenic mice

• however, a delay in onset of papillary thyroid carcinoma is seen compared to mice homozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn mice

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:210015 )

• total number of papillary thyroid carcinomas that form is higher than in single Tg(TG-TPR/NTRK1)#Rstn transgenic mice

• however, a delay in onset of papillary thyroid carcinoma is seen compared to mice homozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn mice

Allelic Composition	Cdkn1b^tm1Kin/Cdkn1b⁺ Lepr^db/Lepr^db
Genetic Background	involves: C57BL/6J * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Kin mutation (1 available); any Cdkn1b mutation (26 available)
Lepr^db mutation (18 available); any Lepr mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

polyphagia ( J:96047 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:96047 )

• islet mass, but not islet density, is significantly increased compared to Lepr single homozygotes

increased pancreatic beta cell number ( J:96047 )

• beta cell proliferation and the total number of beta cells are increased compared to Lepr single homozygotes; however the size of individual beta cells is similar to Lepr single homozygotes

growth/size/body

obese ( J:96047 )

homeostasis/metabolism

hyperglycemia ( J:96047 )

• developed more slowly and to a reduced extent compared to Lepr single homozygotes

increased circulating insulin level ( J:96047 )

hyperlipidemia ( J:96047 )

decreased body temperature ( J:96047 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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