Phenotypes associated with this allele

• Allele Symbol: Dclk1⁺
• Allele Name: wild type
• Allele ID: MGI:2437351
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Dclk1^tm1a(EUCOMM)Wtsi/\Dclk1^+	C57BL/6N-Dclk1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5797468
ht2	\Dclk1^tm1.1Jgg/\Dclk1^+	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618287
cn3	\Apc^Min/\Apc^+ \Dclk1^tm1.1(cre/ERT2)Seno/\Dclk1^+ \Gt(ROSA)26Sor^tm1Sor/\Gt(ROSA)26Sor^tm1(HBEGF)Awai	involves: 129S4/SvJaeSor * C57BL/6	MGI:5475206
cn4	\Ctnnb1^tm1Mmt/\Ctnnb1^+ \Dclk1^tm1.1(cre/ERT2)Seno/\Dclk1^+	involves: 129X1/SvJ * C57BL/6	MGI:5475208
cx5	\Dclk1^tm1.1Jgg/\Dclk1^+ \Dcx^tm1Caw/\Dcx^tm1Caw	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618311
cx6	\Dclk1^tm1.1Jgg/\Dclk1^+ \Dcx^tm1Caw/Y	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618308
cx7	\Dclk1^tm1Caw/\Dclk1^+ \Dcx^tm1Caw/\Dcx^+	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:3628593
cx8	\Dclk1^tm1Caw/\Dclk1^+ \Dcx^tm1Caw/Y	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:3628602

Genotype
MGI:5797468

ht1

• Allelic Composition: \Dclk1^{tm1a(EUCOMM)Wtsi}/\Dclk1⁺
• Genetic Background: C57BL/6N-Dclk1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: MEPD1000_3_H02

Data Sources

IMPC Data for Dclk1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - WTSI

immune system

increased anti-nuclear antigen antibody level ( J:211773 )

IMPC - WTSI

Genotype
MGI:3618287

ht2

• Allelic Composition: \Dclk1^tm1.1Jgg/\Dclk1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

nervous system

abnormal corpus callosum morphology ( J:105300 )

• alterations in corpus callosum thickness are observed in heterozygotes with the appearance of small Probst bundles

Genotype
MGI:5475206

cn3

• Allelic Composition: \Apc^Min/\Apc⁺; \Dclk1^{tm1.1(cre/ERT2)Seno}/\Dclk1⁺; \Gt(ROSA)26Sor^tm1Sor/\Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

neoplasm

abnormal tumor morphology ( J:193873 )

• after tamoxifen treatment and a single injection of diphtheria toxin (DT), polyps contain many Dclk1-positive apoptotic tumor cells and are severely injured or collapsed with Dclk1-negative polyps not displaying DT-induced apoptosis

digestive/alimentary system

digestive/alimentary phenotype ( J:193873 )

N • after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, these cells are absent from the normal intestine with no significant damage to organ architecture observed in the intestine or stomach

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:193873 )

N • after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, no significant damage in organ architecture is observed in the pancreas or gallbladder

Genotype
MGI:5475208

cn4

• Allelic Composition: \Ctnnb1^tm1Mmt/\Ctnnb1⁺; \Dclk1^{tm1.1(cre/ERT2)Seno}/\Dclk1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

neoplasm

neoplasm ( J:193873 )

N • 40 days after tamoxifen treatment, mice show no detectable polyp development in the small intestine

Genotype
MGI:3618311

cx5

• Allelic Composition: \Dclk1^tm1.1Jgg/\Dclk1⁺; \Dcx^tm1Caw/\Dcx^tm1Caw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

nervous system

absent corpus callosum ( J:105300 )

♀ • corpus callosum is absent

Genotype
MGI:3618308

cx6

• Allelic Composition: \Dclk1^tm1.1Jgg/\Dclk1⁺; \Dcx^tm1Caw/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

nervous system

abnormal corpus callosum morphology ( J:105300 )

♂ • corpus callosum is hypoplastic

decreased anterior commissure size ( J:105300 )

♂ • anterior commissure is severely reduced in thickness

abnormal neuron morphology ( J:105300 )

♂ • cortical neuron distribution is altered, with neurons showing a much broader pattern of distribution

Genotype
MGI:3628593

cx7

• Allelic Composition: \Dclk1^tm1Caw/\Dclk1⁺; \Dcx^tm1Caw/\Dcx⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

reproductive system

reduced female fertility ( J:105301 )

♀ • fertility appears to be reduced

Genotype
MGI:3628602

cx8

• Allelic Composition: \Dclk1^tm1Caw/\Dclk1⁺; \Dcx^tm1Caw/Y
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

mortality/aging

postnatal lethality ( J:105301 )

♂ • a slightly lower proportion of Dcx-deficient, Dcamkl1-heterozygous males die postnatally than double knockouts

nervous system

abnormal brain morphology ( J:105301 )

♂ • mutants have less severe and less penetrant white matter defects than double knockouts

enlarged lateral ventricles ( J:105301 )

♂ • lateral ventricles are enlarged in mutants

absent corpus callosum ( J:105301 )

♂ • some animals have an absent corpus callosum