Dclk1^tm1Caw
Targeted Allele Detail

Summary

• Symbol: Dclk1^tm1Caw
• Name: doublecortin-like kinase 1; targeted mutation 1, Christopher A Walsh
• MGI ID: MGI:3626361
• Synonyms: Dclk^-
• Gene: Dclk1 Location: Chr3:55149785-55446489 bp, + strand Genetic Position: Chr3, 26.53 cM, cytoband D
• Alliance: Dclk1^tm1Caw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105301
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to delete exons 9-11, which encode the core of the kinase domain and are common to almost all known transcripts from the locus. A frame shift was introduced into the locus, generating multiple stop codons downstream of exon 9. (J:105301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dclk1 Mutation: 53 strains or lines available

References

• Original: J:105301 Deuel TA, et al., Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006 Jan 5;49(1):41-53
• All: 5 reference(s)