Dcxtm1Caw
Targeted Allele Detail
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Symbol: |
Dcxtm1Caw |
Name: |
doublecortin; targeted mutation 1, Christopher A Walsh |
MGI ID: |
MGI:2387757 |
Synonyms: |
Dcx- |
Gene: |
Dcx Location: ChrX:142638838-142716307 bp, - strand Genetic Position: ChrX, 64.89 cM
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Alliance: |
Dcxtm1Caw page
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Hippocampal disorganization, increased c-fos, and loss of SOM+ interneurons in Dcxtm1Caw/Y Dclk2tm1.2Jgg/Dclk2tm1.2Jgg mice
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:78746
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2 and 3 were replaced by a cassette containing lacZ and neo inserted by homologous recombination. The deleted region encodes the microtubule binding and bundling properties of the protein. Western blot and immunohistochemical analyses showed an absence of protein in hemizygous mutant male mice and reduced levels in heterozygous mutant female mice, indicating that protein is not produced by the targeted loci. Expression of the lacZ gene was driven by the endogenous promoter.
(J:78746)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dcx Mutation: |
18 strains or lines available
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Original: |
J:78746 Corbo JC, et al., Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci. 2002 Sep 1;22(17):7548-57 |
All: |
15 reference(s) |
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