All Phenotypes Mecp2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecp2⁺
wild type
MGI:2432791

Summary

23 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecp2^tm1Hzo/Mecp2⁺	129S7/SvEvBrd-Mecp2^tm1Hzo	MGI:3624554
ht2	Mecp2^tm1.1Joez/Mecp2⁺	B6.129-Mecp2^tm1.1Joez	MGI:5310738
ht3	Mecp2^tm1.1Bird/Mecp2⁺	B6.129P2(C)-Mecp2^tm1.1Bird/J	MGI:6098753
ht4	Mecp2^tm1.1Dhy/Mecp2⁺	C57BL/6N-Mecp2^tm1.1Dhy	MGI:5584026
ht5	Mecp2^tm1Nlnd/Mecp2⁺	involves: 129 * CD-1	MGI:7266283
ht6	Mecp2^tm1.1Bird/Mecp2⁺	involves: 129P2/OlaHsd	MGI:3817236
ht7	Mecp2^tm4.1Bird/Mecp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5529466
ht8	Mecp2^tm6.1Bird/Mecp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5702957
ht9	Mecp2^tm5.1Bird/Mecp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5529467
ht10	Mecp2^tm2Bird/Mecp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3712286
ht11	Mecp2^tm1.1Bird/Mecp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3624718
ht12	Mecp2^tm1Pplt/Mecp2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3801488
ht13	Mecp2^tm1Vnar/Mecp2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl	MGI:4949887
ht14	Mecp2^tm1.1Irsf/Mecp2⁺	involves: 129S2/SvPas * C57BL/6	MGI:5751716
ht15	Mecp2^tm1.1Jae/Mecp2⁺	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:3624676
ht16	Mecp2^tm1.1Jae/Mecp2⁺	involves: 129S4/SvJae * C57BL/6	MGI:3043303
ht17	Mecp2^tm1.1Jtc/Mecp2⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5568998
ht18	Mecp2^tm1.1Irsf/Mecp2⁺	involves: 129S/Sv * C57BL/6	MGI:5429579
ht19	Mecp2^tm1.1Mitoh/Mecp2⁺	Not Specified	MGI:5427623
cn20	Mecp2^tm2Bird/Mecp2⁺ Tg(CAG-cre/Esr1*)5Amc/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3712287
cn21	Mecp2^tm1Jae/Mecp2⁺ Tg(Nes-cre)1Atp/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:3624684
cx22	Mecp2^em1Dkatz/Mecp2⁺ Tyr^c-ch/Tyr^c-ch	FVB.Cg-Pde6b⁺ Tyr^c-ch Mecp2^em1Dkatz/J	MGI:6159334
cx23	Mapt^{tm1(Mecp2)Jae}/Mapt⁺ Mecp2^tm1.1Jae/Mecp2⁺	involves: 129S4/SvJae * C57BL/6	MGI:3043301

Allelic Composition	Mecp2^tm1Hzo/Mecp2⁺
Genetic Background	129S7/SvEvBrd-Mecp2^tm1Hzo

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Hzo mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:78009 )

• females display milder and more variable features of Rett Syndrome than males, presumably due to differences in the pattern of X chromosome inactivation

tremors ( J:78009 )

• 62% of females exhibit tremors

impaired coordination ( J:78009 )

• in the wire suspension test, females show normal performance at 5-6 weeks of age, but are impaired at older ages (35-39 weeks)

• females perform as well as wild-type on a thin horizontal wooden dowel, even at 35-39 weeks of age

increased stereotypic behavior ( J:78009 )

• 69% of females display stereotypic forepaw movements (rapid and repetitive movement of the forelimbs, often bring them together)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:78009

Allelic Composition	Mecp2^tm1.1Joez/Mecp2⁺
Genetic Background	B6.129-Mecp2^tm1.1Joez

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Joez mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:181311 )

N	• mice exhibit normal survival

behavior/neurological

abnormal behavior ( J:181311 )

• mice exhibit RTT-like symptoms after 17 weeks of age

decreased locomotor activity ( J:181311 )

• at 20, but not 12, weeks of age

growth/size/body

increased body weight ( J:181311 )

Allelic Composition	Mecp2^tm1.1Bird/Mecp2⁺
Genetic Background	B6.129P2(C)-Mecp2^tm1.1Bird/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Bird mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart rate ( J:241788 )

• 9 month old females exhibit erratic heart rate patterns, with sudden pauses in the regular rhythm of the heart rate and bradycardic events

increased heart rate variability ( J:241788 )

decreased heart rate ( J:241788 )

• mice have a higher incidence of sudden bradycardic events

• 28 month old females develop a decreased heart rate which is not seen in 9 month old mice

irregular heartbeat ( J:241788 )

• 9 month old females present with a variety of spontaneous cardiac arrhythmias ranging from sinus pauses and atrioventricular block to aberrant ventricular contractions

• non-sustained ventricular arrhythmias are seen in 9 month old females

ventricular premature beat ( J:241788 )

• 9 month old males are susceptible to premature ventricular contractions

atrioventricular block ( J:241788 )

• atrioventricular block is seen at a higher rate in 9 month old females

homeostasis/metabolism

decreased body temperature ( J:241788 )

• 28 month old females develop decreased temperature which is not seen in 9 month old mice

behavior/neurological

behavior/neurological phenotype ( J:241788 )

N	• mice exhibit normal activity levels during both the light and dark cycles at 9 and 28 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:241788

Allelic Composition	Mecp2^tm1.1Dhy/Mecp2⁺
Genetic Background	C57BL/6N-Mecp2^tm1.1Dhy

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Dhy mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:209069 )

• at 30 weeks, mice exhibit mild neurological defects (determined by scoring of level of grooming, ambulation, presence of skin sores, abdomen size and response to tail suspension) as in Mecp2^tm1.1Bird mice

limb grasping ( J:209069 )

• delayed hind limb clasping

growth/size/body

growth/size/body region phenotype ( J:209069 )

N	• mice exhibit normal weight, body length and body mass index

Allelic Composition	Mecp2^tm1Nlnd/Mecp2⁺
Genetic Background	involves: 129 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Nlnd mutation (0 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:268051 )

N	• females do not show reduced longevity in the first year of life

growth/size/body

obese ( J:268051 )

• body weight is indistinguishable from wild-type mice at early postnatal days but it progressively increases with aging, leading to obesity

behavior/neurological

abnormal behavior ( J:268051 )

• females start showing Rhett-like features at 9 weeks of age, with worsening of the general condition and mobility, hind limb clasping and tremors

limb grasping ( J:268051 )

• hind limb clasping appears with age

tremors ( J:268051 )

• tremor is the first symptom to appear

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:268051

Allelic Composition	Mecp2^tm1.1Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Bird mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus morphology ( J:194039 )

• decrease in the number of ATRX containing foci in null cells only

abnormal cerebral cortex morphology ( J:194039 )

• decrease in the number of ATRX containing foci in null cells only

decreased neuron number ( J:108953 )

• 7-9 week old adults have 33% the number of Mecp2-expressing neurons compared to young adult wild-type

• compared to age-matched wild-type adults, 24-95 week old heterozygotes have 68% the number of Mecp2-expressing cortical neurons; number of Mecp2-expressing neurons is significantly higher in younger mutants than in older mutants

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:108953 )

• X-chromosome inactivation becomes unbalance in older mutants, with a larger percentage expressing Mecp2 compared to younger mutants (>50%)

Allelic Composition	Mecp2^tm4.1Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm4.1Bird mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

• females exhibit milder motor coordination and behavioral phenotypes than males

Allelic Composition	Mecp2^tm6.1Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm6.1Bird mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

• females exhibit milder motor coordination and behavioral phenotypes than males

Allelic Composition	Mecp2^tm5.1Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm5.1Bird mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

• females exhibit milder motor coordination and behavioral phenotypes than males

Allelic Composition	Mecp2^tm2Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:118365 )

• at 4 to 12 months of age, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

limb grasping ( J:118365 )

• at 4 to 12 months of age

tremors ( J:118365 )

• at 4 to 12 months of age

growth/size/body

obese ( J:118365 )

• mice exhibit excess weight gain

nervous system

reduced long-term potentiation ( J:118365 )

• mice develop a reduction in long term potentiation

respiratory system

abnormal breathing pattern ( J:118365 )

• at 4 to 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:118365

Allelic Composition	Mecp2^tm1.1Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Bird mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:67910 )

• acquire hindlimb clasping at ages greater than 3 months

decreased locomotor activity ( J:67910 )

• although heterozygous females initially show no symptoms and raise normal litters, they acquire inertia at ages greater than 3 months

• in an open field test, visit fewer squares, spend more time being immotile and rear less than controls, however this is not due to increased anxiety, as fecal bolus counts, grooming times and time spent in different zones of the field are similar to controls

respiratory system

abnormal breathing pattern ( J:67910 )

• often exhibit breathing irregularities by 9 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:67910

Allelic Composition	Mecp2^tm1Pplt/Mecp2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Pplt mutation (0 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:137344 )

• motor defect on initial exposure to rotarod test

• rotarod performance normalized when maintained in an "enriched" environment

• rotarod performance improves over 5 days of training

• rotarod performance remains deficient relative to wild-type kept in a standard environment

• coordination improvement acquired with training is lost in the weeks subsequent to training

• "enriched" environment prevents coordination deficiency from developing

decreased vertical activity ( J:137344 )

• reduced rearing activity regardless of the environment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:137344

Allelic Composition	Mecp2^tm1Vnar/Mecp2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Vnar mutation (0 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:171410 )

N	• mice live longer than 14 months with no unusual health issues

reproductive system

reproductive system phenotype ( J:171410 )

N	• mice exhibit normal fertility

behavior/neurological

behavior/neurological phenotype ( J:171410 )

N	• mice do not exhibit seizures or tremors

Allelic Composition	Mecp2^tm1.1Irsf/Mecp2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Irsf mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:220859 )

• mice show increased footslips in the parallel rod walking task and impaired ability to learn the accelerating rotating rod walking task at 17 weeks of age

• however, no difference is seen in the motor coordination task of dowel hang time and mice exhibit normal behaviors in the elevated plus maze

tonic-clonic seizures ( J:220859 )

• two mice show tonic-clonic seizures followed by death after handling

respiratory system

increased pulmonary respiratory rate ( J:220859 )

• 8 month old mice exhibit increased breathing rate when exposed to a hypoxic gas challenge

cardiovascular system

increased heart weight ( J:220859 )

• increase in heart weight by 8 months

prolonged QT interval ( J:220859 )

• 8 month old mice show increased corrected QT interval time

growth/size/body

increased heart weight ( J:220859 )

• increase in heart weight by 8 months

increased body weight ( J:220859 )

• mice become overweight by 10 weeks of age

increased liver weight ( J:220859 )

• increase in liver weight by 8 months of age

liver/biliary system

increased liver weight ( J:220859 )

• increase in liver weight by 8 months of age

mortality/aging

premature death ( J:220859 )

• median survival of 224 days

nervous system

tonic-clonic seizures ( J:220859 )

• two mice show tonic-clonic seizures followed by death after handling

decreased brain weight ( J:220859 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:220859

Allelic Composition	Mecp2^tm1.1Jae/Mecp2⁺
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:67909 )

• females appear normal for the first 4 months but show ataxic gait at later ages

decreased locomotor activity ( J:67909 )

• females appear normal for the first 4 months but show hypoactivity at later ages

growth/size/body

increased susceptibility to age related obesity ( J:67909 )

• females appear normal for the first 4 months but gain weight at later ages

respiratory system

abnormal breathing pattern ( J:181342 )

• mutants at 10 weeks of age exhibit an abnormally high breathing frequency associated with marked decreases in expiratory time and total breath duration and a small but significant decrease in inspiratory time

• treatment with LM22A-4, a small molecule BDNF loop domain mimetic that acts as a selective TrkB agonist, improves the respiratory function of mutants

tachypnea ( J:181342 )

• breathing dysfunction is characterized by increased frequency due to periods of tachypnea and increased apneas

apnea ( J:181342 )

• 20% of mutants exhibit apneas at 8 weeks of age and by 12 weeks of age, 50% of mutants exhibit apneas

• number of apneas increases between 8 and 12 weeks of age in mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:181342

Allelic Composition	Mecp2^tm1.1Jae/Mecp2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:89593 )

growth/size/body

decreased body weight ( J:89593 )

• mutants are severely underweight from 4-5 weeks of age

nervous system

decreased brain weight ( J:89593 )

• 8 - 13 week old mutants display a 14-18% reduction in brain weight

Allelic Composition	Mecp2^tm1.1Jtc/Mecp2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Jtc mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired long-term object recognition memory ( J:209637 )

• object memory is intact at 1 hour, but impaired at 24 hours after object training, however, the impairment occurs to a lesser degree than in males

increased fear-related response ( J:209637 )

• females freeze for a larger percentage of time during the acquisition phase of the associative fear conditioning task as compared to wild type on day 80, but not on postnatal day 40

impaired coordination ( J:209637 )

• reduced latency to fall from rotarod as compared to wild type on postnatal day 30

decreased locomotor activity ( J:209637 )

• reduced ambulatory movements (two consecutive beam breaks) as compared to wild type on postnatal day 63

• reduced fine motor movements (repeated breaking of same beam) as compared to wild type on postnatal day 63

tonic-clonic seizures ( J:209637 )

• tonic-clonic seizures observed in 3.7% (5/136) of females

• seizures appear to be stimulated by touch

• mice die within a month of seizures

growth/size/body

decreased body weight ( J:209637 )

• reduced body weight as compared to wild type on postnatal day 64

nervous system

tonic-clonic seizures ( J:209637 )

• tonic-clonic seizures observed in 3.7% (5/136) of females

• seizures appear to be stimulated by touch

• mice die within a month of seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:209637

Allelic Composition	Mecp2^tm1.1Irsf/Mecp2⁺
Genetic Background	involves: 129S/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Irsf mutation (1 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:185639 )

• moderate obesity seen in some female mice

behavior/neurological

lethargy ( J:185639 )

• in some female mice

impaired coordination ( J:185639 )

• in some female mice

Allelic Composition	Mecp2^tm1.1Mitoh/Mecp2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Mitoh mutation (0 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placentas of embryos carrying a maternal Mecp2^tm1.1Mitoh allele exhibit increased apoptosis

mortality/aging

preweaning lethality, incomplete penetrance ( J:184364 )

• fewer mice are born when this allele is inherited maternally

• however, birth rates are normal when this allele is inherited paternally

embryo

increased placenta apoptosis ( J:184364 )

• when this allele is inherited maternally, E13.5 mice exhibit increased apoptosis compared with control mice

• however, mice do not exhibit increased apoptosis when this allele is paternally inherited

abnormal placenta morphology ( J:184364 )

• when this allele is inherited maternally

nervous system

nervous system phenotype ( J:184364 )

N	• mice do not exhibit any RTT-associated neurological phenotypes

cellular

increased placenta apoptosis ( J:184364 )

• when this allele is inherited maternally, E13.5 mice exhibit increased apoptosis compared with control mice

• however, mice do not exhibit increased apoptosis when this allele is paternally inherited

Allelic Composition	Mecp2^tm2Bird/Mecp2⁺ Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (46 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:118365 )

• at 4 to 12 months of age, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

limb grasping ( J:118365 )

• at 4 to 12 months of age

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

tremors ( J:118365 )

• at 4 to 12 months of age

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

nervous system

reduced long-term potentiation ( J:118365 )

• mice develop a reduction in long term potentiation

• however, treatment with tamoxifen returns long term potentiation to normal levels

respiratory system

abnormal breathing pattern ( J:118365 )

• at 4 to 12 months of age

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

growth/size/body

obese ( J:118365 )

• mice exhibit excess weight gain

• however, tamoxifen treatment after the onset of symptoms reverses weight gain

Allelic Composition	Mecp2^tm1Jae/Mecp2⁺ Tg(Nes-cre)1Atp/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (46 available)
Tg(Nes-cre)1Atp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:67909 )

• females appear normal for the first 4 months but show ataxic gait at later ages

decreased locomotor activity ( J:67909 )

• females appear normal for the first 4 months but show hypoactivity at later ages

growth/size/body

increased susceptibility to age related obesity ( J:67909 )

• females appear normal for the first 4 months but gain weight at later ages

Allelic Composition	Mecp2^em1Dkatz/Mecp2⁺ Tyr^c-ch/Tyr^c-ch
Genetic Background	FVB.Cg-Pde6b⁺ Tyr^c-ch Mecp2^em1Dkatz/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^em1Dkatz mutation (0 available); any Mecp2 mutation (46 available)
Tyr^c-ch mutation (79 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:101977 )

• females exhibit a locomotor phenotype onset as early as 14 weeks of age

reproductive system

reproductive system phenotype ( J:101977 )

N	• fertility is normal

Allelic Composition	Mapt^{tm1(Mecp2)Jae}/Mapt⁺ Mecp2^tm1.1Jae/Mecp2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^{tm1(Mecp2)Jae} mutation (1 available); any Mapt mutation (453 available)
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:89593 )

N	• mutant activity as measured by exploratory response and total nocturnal activity does not differ from wild-type mice

growth/size/body

growth/size/body region phenotype ( J:89593 )

N	• mutants display normal body weight

nervous system

nervous system phenotype ( J:89593 )

N	• mutants display normal brain weight

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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