Mecp2^tm1.1Mitoh
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm1.1Mitoh
• Name: methyl CpG binding protein 2; targeted mutation 1.1, Masayuki Itoh
• MGI ID: MGI:5427621
• Synonyms: X^e2-
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm1.1Mitoh page

Placentas of embryos carrying a maternal Mecp2^tm1.1Mitoh allele exhibit increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184364
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a modified exon 2 containing the untranslated region (2x) fused to a tetracycline transactivator (2x-tTA), a loxP site, an FRT-flanked neo cassette, a tetracycline responsive promoter (TRE) fused to the coding sequence of exon 2 (2y; TRE-2y), and a loxP site. Cre-mediated recombination removed the neo cassette and TRE-2y. (J:184364)

Generation of the Mecp2^tm1.1Mitoh allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 45 strains or lines available

References

• Original: J:184364 Itoh M, et al., Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development. J Biol Chem. 2012 Apr 20;287(17):13859-67
• All: 1 reference(s)