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| Caption | A) Strategy for selective targeting of the e2 isoform of Mecp2. Transcription start sites for Mecp2 isoform e2 (MeCP2_e2) and Mecp2 isoform e1 (MeCP2_e1) before and after exon 2 disruption are shown. LoxP sites are denoted as filled triangles. Relative location of probes for Southern hybridization, and positions of restriction enzymes BamHI (B) and PvuII (P) are indicated. Crossing of MeCP2_e2 conditional mice with Nestin-Cre deleter mice results in the excision of the transcriptional start site of MeCP2_e2 and the creation of the MeCP2_e2 null allele, Mecp2tm1.1Mitoh, not only in neuronal cells but also in the germ line. Note that the transcriptional start of MeCP2_e1 remains intact after disruption of the Mecp2 locus. | ||||
| Copyright | This image is from Itoh M, J Biol Chem 2012 Apr 20;287(17):13859-67 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:184364 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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