All Phenotypes Mecp2<tm1.1Mitoh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecp2^tm1.1Mitoh
targeted mutation 1.1, Masayuki Itoh
MGI:5427621

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecp2^tm1.1Mitoh/Mecp2^tm1.1Mitoh	Not Specified	MGI:5427624
ht2	Mecp2^tm1.1Mitoh/Mecp2⁺	Not Specified	MGI:5427623
ot3	Mecp2^tm1.1Mitoh/Y	Not Specified	MGI:5427622

Allelic Composition	Mecp2^tm1.1Mitoh/Mecp2^tm1.1Mitoh
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Mitoh mutation (0 available); any Mecp2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:184364 )

• fewer mice are born when this allele is inherited maternally

• however, birth rates are normal when this allele is inherited paternally

Allelic Composition	Mecp2^tm1.1Mitoh/Mecp2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Mitoh mutation (0 available); any Mecp2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placentas of embryos carrying a maternal Mecp2^tm1.1Mitoh allele exhibit increased apoptosis

mortality/aging

preweaning lethality, incomplete penetrance ( J:184364 )

• fewer mice are born when this allele is inherited maternally

• however, birth rates are normal when this allele is inherited paternally

embryo

increased placenta apoptosis ( J:184364 )

• when this allele is inherited maternally, E13.5 mice exhibit increased apoptosis compared with control mice

• however, mice do not exhibit increased apoptosis when this allele is paternally inherited

abnormal placenta morphology ( J:184364 )

• when this allele is inherited maternally

nervous system

nervous system phenotype ( J:184364 )

N	• mice do not exhibit any RTT-associated neurological phenotypes

cellular

increased placenta apoptosis ( J:184364 )

• when this allele is inherited maternally, E13.5 mice exhibit increased apoptosis compared with control mice

• however, mice do not exhibit increased apoptosis when this allele is paternally inherited

Allelic Composition	Mecp2^tm1.1Mitoh/Y
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Mitoh mutation (0 available); any Mecp2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placentas of embryos carrying a maternal Mecp2^tm1.1Mitoh allele exhibit increased apoptosis

mortality/aging

preweaning lethality, incomplete penetrance ( J:184364 )

• fewer mice are born when this allele is inherited maternally

• however, birth rates are normal when this allele is inherited paternally

embryo

increased placenta apoptosis ( J:184364 )

• when this allele is inherited maternally, E13.5 mice exhibit increased apoptosis compared with control mice

• however, mice do not exhibit increased apoptosis when this allele is paternally inherited

abnormal placenta morphology ( J:184364 )

• when this allele is inherited maternally

nervous system

nervous system phenotype ( J:184364 )

N	• mice do not exhibit any RTT-associated neurological phenotypes

cellular

increased placenta apoptosis ( J:184364 )

• when this allele is inherited maternally, E13.5 mice exhibit increased apoptosis compared with control mice

• however, mice do not exhibit increased apoptosis when this allele is paternally inherited

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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