All Phenotypes Il4<tm1Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il4^tm1Cgn
targeted mutation 1, University of Cologne
MGI:1857194

Summary

18 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il4^tm1Cgn/Il4^tm1Cgn	B6.129P2-Il4^tm1Cgn/J	MGI:4818944
hm2	Il4^tm1Cgn/Il4^tm1Cgn	B6.Cg-Il4^tm1Cgn	MGI:3038309
hm3	Il4^tm1Cgn/Il4^tm1Cgn	either: NOD.129-Il4^tm1Cgn or (involves: 129 * NOD)	MGI:3625060
hm4	Il4^tm1Cgn/Il4^tm1Cgn	involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss	MGI:4843968
hm5	Il4^tm1Cgn/Il4^tm1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3689881
hm6	Il4^tm1Cgn/Il4^tm1Cgn	involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp	MGI:4839052
hm7	Il4^tm1Cgn/Il4^tm1Cgn	involves: 129P2/OlaHsd * NOD	MGI:3623295
hm8	Il4^tm1Cgn/Il4^tm1Cgn	MRL.129P2-Il4^tm1Cgn	MGI:3799735
hm9	Il4^tm1Cgn/Il4^tm1Cgn	NOD.129P2-Il4^tm1Cgn	MGI:3622411
hm10	Il4^tm1Cgn/Il4^tm1Cgn	NOD.Cg-H2^b Il4^tm1Cgn	MGI:3622418
cx11	Il21r^tm1Wjl/Il21r^tm1Wjl Il4^tm1Cgn/Il4^tm1Cgn	involves: 129 * C57BL/6	MGI:3813932
cx12	Il4^tm1Cgn/Il4^tm1Cgn Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}	involves: 129P2/OlaHsd	MGI:5550267
cx13	Il4^tm1Cgn/Il4^tm1Cgn Tg(CD2-Stat6V625AT626A)78Mhk/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:4818945
cx14	Il2^tm1Hor/Il2^tm1Hor Il4^tm1Cgn/Il4^tm1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3759409
cx15	Il10^tm1Cgn/Il10^tm1Cgn Il4^tm1Cgn/Il4^tm1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3851988
cx16	Fas^lpr/Fas^lpr Il4^tm1Cgn/Il4^tm1Cgn	involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp	MGI:4839051
cx17	Fas^lpr/Fas^lpr Il4^tm1Cgn/Il4^tm1Cgn	MRL.Cg-Il4^tm1Cgn Fas^lpr	MGI:3799736
cx18	Il4^tm1Cgn/Il4^tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0	NOD.Cg-Il4^tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi	MGI:3625063

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	B6.129P2-Il4^tm1Cgn/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:44346 , J:160119 )

N	• survival time of cardiac allografts (BALB/c origin) is similar to wild-type mice, unlike in Ifng or Il10 null mice (J:44346) • dendritic function is normal (J:160119)

integument

abnormal skin physiology ( J:160119 )

• despite normal dendritic function, mice whose backs are shaved and painted with Alexa 647-labeled ovalbumin accumulate fewer Alexa647+CD11c+ cells in draining lymph nodes compared with similarly treated wild-type mice indicating increased barrier function

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	B6.Cg-Il4^tm1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 2 physiology ( J:89095 )

• homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization

• eosinophil infiltration is impaired in response to schistosome egg immunization

abnormal humoral immune response ( J:89095 )

• IgG1 response to immunization with the protein antigen OVA is severely impaired

hematopoietic system

abnormal T-helper 2 physiology ( J:89095 )

• homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization

• eosinophil infiltration is impaired in response to schistosome egg immunization

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	either: NOD.129-Il4^tm1Cgn or (involves: 129 * NOD)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

insulitis ( J:85924 )

• at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)

immune system

insulitis ( J:85924 )

• at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)

autoimmune response ( J:85924 )

• there is no difference in timing or penetrance of diabetes in IL4-deficient NOD mice (N8) compared to heterozygous or wild-type NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:85924

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:119207 )

• abnormal IgG responses to HgCL2 exposure

• however, mercury induced increases in autoantibodies are similar to controls

immune system

decreased IgG1 level ( J:119207 )

• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice

increased IgG2a level ( J:119207 )

• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice

hematopoietic system

decreased IgG1 level ( J:119207 )

• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice

increased IgG2a level ( J:119207 )

• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgE level ( J:704 )

• there were no dectectable levels of IgE in 5 of 6 mice compared to controls, which all had dectectable levels

• after infection with a nematode, 6-week old animals have almost undetectable IgE levels compared to controls which show about 50-fold increase in levels after infection

decreased IgG1 level ( J:704 )

• homozygotes have about 1/6 the level of IgG1 of wild-type at 6 weeks

• in response to immunization with chicken globulin, antibodies produced by mutants are ~40-50% IgG1, while wild-type mice produce >95% IgG1-specific antibodies

abnormal cytokine secretion ( J:704 )

• conA stimulated spleen cells from homozygotes secrete ~800-fold less Il4 than control cells

granulomatous inflammation ( J:113543 )

• upon infection with Schistosoma mansoni eggs, primary granuloma formation and volume is equivalent to wild-type

• volumes of secondary granulomas after second exposure with parasite eggs are reduced by ~50% compared to wild-type

hematopoietic system

decreased IgE level ( J:704 )

• there were no dectectable levels of IgE in 5 of 6 mice compared to controls, which all had dectectable levels

• after infection with a nematode, 6-week old animals have almost undetectable IgE levels compared to controls which show about 50-fold increase in levels after infection

decreased IgG1 level ( J:704 )

• homozygotes have about 1/6 the level of IgG1 of wild-type at 6 weeks

• in response to immunization with chicken globulin, antibodies produced by mutants are ~40-50% IgG1, while wild-type mice produce >95% IgG1-specific antibodies

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgE level ( J:39600 )

• at 3 months of age relative to wild-type controls

decreased IgG1 level ( J:39600 )

• at 3 and 7-8 months of age relative to wild-type controls

hematopoietic system

decreased IgE level ( J:39600 )

• at 3 months of age relative to wild-type controls

decreased IgG1 level ( J:39600 )

• at 3 and 7-8 months of age relative to wild-type controls

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgG1 level ( J:85924 )

• CD4+ T cells from deficient animals show a reduction in circulating IgG1 in the absence of deliberate immunization

abnormal cytokine secretion ( J:85924 )

• CD4+ T cells from deficient animals show a strongly reduced ability to produce Il5 after anti-TCR stimulation compared to wild-type cells

hematopoietic system

decreased IgG1 level ( J:85924 )

• CD4+ T cells from deficient animals show a reduction in circulating IgG1 in the absence of deliberate immunization

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	MRL.129P2-Il4^tm1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 12% of infiltrate

• B cells are more abundant in infiltrates (30%) than in MRL.Cg- Il4^tm1Cgn Fas^lpr mice

vision/eye

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 12% of infiltrate

• B cells are more abundant in infiltrates (30%) than in MRL.Cg- Il4^tm1Cgn Fas^lpr mice

endocrine/exocrine glands

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 12% of infiltrate

• B cells are more abundant in infiltrates (30%) than in MRL.Cg- Il4^tm1Cgn Fas^lpr mice

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	NOD.129P2-Il4^tm1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:95105 )

• mice are diabetic if 2 consecutive measures of blood glucose are >240 mg/dl

abnormal enzyme/coenzyme activity ( J:105803 )

• amylase activity increases slightly between 4 and 20 weeks of age (234 to 291 U/L) compared to activity in wild-type which declines

• parotid secretory protein protease activity is retained in mutants while non-diseased BALB/c animals do not show activity

endocrine/exocrine glands

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

immune system

decreased susceptibility to autoimmune disorder ( J:95105 )

• in null females challenged with coxsackievirus B4 at 8 weeks of age, diabetes onset is not accelerated as it is in wild-type NOD females; over the 25-week follow up period, only 23% of CVB4 exposed nulls develop diabetes compared to 63% of saline-treated controls

increased susceptibility to autoimmune disorder ( J:95105 )

• at 12 weeks of age, null females challenged with CVB4 develop diabetes at an accelerated rate compared with saline-treated controls (80% at 10 days after infection versus 30% of controls)

digestive/alimentary system

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:105803

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	NOD.Cg-H2^b Il4^tm1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:105803 )

• amylase activity increases slightly between 4 and 20 weeks of age(181 to 250 U/L) compared to activity in wild-type which decreases (386 to 288 U/L)

• parotid secretory protein protease activity is retained in mutants while non-diseased animals do not show activity

endocrine/exocrine glands

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

salivary gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

lacrimal gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

immune system

salivary gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

lacrimal gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

vision/eye

lacrimal gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

digestive/alimentary system

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

salivary gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:105803

Allelic Composition	Il21r^tm1Wjl/Il21r^tm1Wjl Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21r^tm1Wjl mutation (6 available); any Il21r mutation (41 available)
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immunoglobulin level ( J:80474 )

decreased IgA level ( J:80474 )

• serum levels of IgGA in nave mice are lower than in controls

• similar defects are noted upon immunization with keyhole limpet hemocyanin (KLH)

decreased IgG1 level ( J:80474 )

• serum levels of IgG1 in nave mice are several log units lower than in controls

• these mice have severely impaired production of antigen-specific IgG1 after immunization with trinitrophenyl-conjugated chicken gamma-globulin (TNP-CGG)

• similar defects are noted upon immunization with KLH

decreased IgG2a level ( J:80474 )

• serum levels of IgG2a in nave mice are lower than in controls

• these mice have severely impaired production of antigen-specific IgG2a after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

decreased IgG2b level ( J:80474 )

• serum levels of IgG2b in nave mice are lower than in controls

• these mice have severely impaired production of antigen-specific IgG2b after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

decreased IgG3 level ( J:80474 )

• serum levels of IgG3 in nave mice are lower than in controls

• these mice have severely impaired production of antigen-specific IgG3 after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

decreased IgM level ( J:80474 )

• these mice have 10 to 20% of normal production levels of antigen-specific IgG2b after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

abnormal lymph node germinal center morphology ( J:80474 )

• lymph nodes after immunization have barely recognizable, poorly organized germinal center-like areas with scattered apoptotic cells

hematopoietic system

abnormal immunoglobulin level ( J:80474 )

decreased IgA level ( J:80474 )

• serum levels of IgGA in nave mice are lower than in controls

• similar defects are noted upon immunization with keyhole limpet hemocyanin (KLH)

decreased IgG1 level ( J:80474 )

• serum levels of IgG1 in nave mice are several log units lower than in controls

• these mice have severely impaired production of antigen-specific IgG1 after immunization with trinitrophenyl-conjugated chicken gamma-globulin (TNP-CGG)

• similar defects are noted upon immunization with KLH

decreased IgG2a level ( J:80474 )

• serum levels of IgG2a in nave mice are lower than in controls

• these mice have severely impaired production of antigen-specific IgG2a after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

decreased IgG2b level ( J:80474 )

• serum levels of IgG2b in nave mice are lower than in controls

• these mice have severely impaired production of antigen-specific IgG2b after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

decreased IgG3 level ( J:80474 )

• serum levels of IgG3 in nave mice are lower than in controls

• these mice have severely impaired production of antigen-specific IgG3 after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

decreased IgM level ( J:80474 )

• these mice have 10 to 20% of normal production levels of antigen-specific IgG2b after immunization with TNP-CGG

• similar defects are noted upon immunization with KLH

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)
Ndfip1^{Gt(RRD002)Byg} mutation (0 available); any Ndfip1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205692 )

• due to inflammatory disease

immune system

increased eosinophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased neutrophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased CD4-positive, alpha-beta T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased interleukin-2 secretion ( J:205692 )

• compared with Il4^tm1Cgn homozygotes

increased inflammatory response ( J:205692 )

• at 12, but not 6, weeks

esophageal inflammation ( J:205692 )

lung inflammation ( J:205692 )

digestive/alimentary system

esophageal epithelium hyperplasia ( J:205692 )

esophageal inflammation ( J:205692 )

respiratory system

lung inflammation ( J:205692 )

lung epithelium hyperplasia ( J:205692 )

hematopoietic system

increased eosinophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased neutrophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased CD4-positive, alpha-beta T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn Tg(CD2-Stat6V625AT626A)78Mhk/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)
Tg(CD2-Stat6*V625A*T626A)78Mhk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:160119 )

N	• mice do not exhibit skin inflammation unlike Tg(CD2-Stat6V625AT626A)78Mhk mice • mice exhibit normal recovery from retinoic acid treatment

Allelic Composition	Il2^tm1Hor/Il2^tm1Hor Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2^tm1Hor mutation (5 available); any Il2 mutation (41 available)
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased B cell proliferation ( J:16662 )

• B cells from lymph nodes have a larger size, and incorporate more BrdU indicating a faster proliferation rate

increased T cell proliferation ( J:16662 )

• 2-10 fold higher using in vivo incorporation of BrdU, which indicates a faster proliferation rate

immune system

increased B cell proliferation ( J:16662 )

• B cells from lymph nodes have a larger size, and incorporate more BrdU indicating a faster proliferation rate

increased T cell proliferation ( J:16662 )

• 2-10 fold higher using in vivo incorporation of BrdU, which indicates a faster proliferation rate

increased pro-B cell number ( J:16662 )

• found in bone marrow

increased pre-B cell number ( J:16662 )

• found in bone marrow

decreased IgG level ( J:16662 , J:26861 )

• there are decreased levels of viral specific antibodies 9 days after infection with lymphocytic choriomeningitis virus (J:16662)

• serum levels of IgG and IgE are close to normal in uninfected mice, compared to the high levels of these immunoglobulins found in mice with just the mutant Il2 locus (J:16662)

decreased cytotoxic T cell cytolysis ( J:26861 )

• there is a nine fold reduction of target cell killing by primary T cells in a chromium release assay

• there is no target cell killing by previously stimulated T cells in a chromium release assay

• footpad swelling is strongly reduced 6-10 days after infection with lymphocytic choriomeningitis virus

abnormal susceptibility to Riboviria infection ( J:26861 )

• despite reduced cytotoxic T cell activity, mice still eliminate lymphocytic choriomeningitis virus within nine days of infection

hematopoietic system

increased B cell proliferation ( J:16662 )

• B cells from lymph nodes have a larger size, and incorporate more BrdU indicating a faster proliferation rate

increased T cell proliferation ( J:16662 )

• 2-10 fold higher using in vivo incorporation of BrdU, which indicates a faster proliferation rate

increased pro-B cell number ( J:16662 )

• found in bone marrow

increased pre-B cell number ( J:16662 )

• found in bone marrow

decreased IgG level ( J:16662 , J:26861 )

• there are decreased levels of viral specific antibodies 9 days after infection with lymphocytic choriomeningitis virus (J:16662)

• serum levels of IgG and IgE are close to normal in uninfected mice, compared to the high levels of these immunoglobulins found in mice with just the mutant Il2 locus (J:16662)

decreased cytotoxic T cell cytolysis ( J:26861 )

• there is a nine fold reduction of target cell killing by primary T cells in a chromium release assay

• there is no target cell killing by previously stimulated T cells in a chromium release assay

• footpad swelling is strongly reduced 6-10 days after infection with lymphocytic choriomeningitis virus

Allelic Composition	Il10^tm1Cgn/Il10^tm1Cgn Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10^tm1Cgn mutation (15 available); any Il10 mutation (44 available)
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 1 cell differentiation ( J:111712 )

• mice exhibit enhanced Th1 responses after infection with S. mansoni eggs compared to controls

increased interferon-gamma secretion ( J:111712 )

• there is a 75-fold increase in IFN-gamma mRNA in the lungs after infection with S. mansoni eggs

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:111712 )

• mice exhibit enhanced Th1 responses after infection with S. mansoni eggs compared to controls

Allelic Composition	Fas^lpr/Fas^lpr Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (82 available)
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal spleen size ( J:39600 )

• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Il4

enlarged spleen ( J:39600 )

increased spleen weight ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

spleen hyperplasia ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased immunoglobulin level ( J:39600 )

decreased IgA level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgE level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG1 level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG3 level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

abnormal lymph node size ( J:39600 )

• lympadenopathy (based on lymph node weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Il4

decreased susceptibility to systemic lupus erythematosus ( J:39600 )

• while mice develop the typical autoimmune lesions end organ disease is decreased compared to mice homozygous for Fas^lpr and wild-type for Ifng

• incidence of end organ disease is increased compared to wild-type controls

decreased anti-nuclear antigen antibody level ( J:39600 )

• decrease in the percentage of FANA positive sera compared to controls at 3 months of age

• however, no significant differences in anti-dsDNA or anti-snRNP autoantibody levels are detected

homeostasis/metabolism

decreased circulating creatinine level ( J:39600 )

• levels are lower compared to mice homozygous for Fas^lpr and wild-type for Il4

hematopoietic system

abnormal spleen size ( J:39600 )

• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Il4

enlarged spleen ( J:39600 )

increased spleen weight ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

spleen hyperplasia ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased immunoglobulin level ( J:39600 )

decreased IgA level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgE level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG1 level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG3 level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

growth/size/body

enlarged spleen ( J:39600 )

increased spleen weight ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

spleen hyperplasia ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

Allelic Composition	Fas^lpr/Fas^lpr Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	MRL.Cg-Il4^tm1Cgn Fas^lpr

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 16% of infiltrate

• B cells are somewhat less abundant in infiltrates (18%) than in double mutants

glomerulonephritis ( J:132514 )

• less severe than MRL/MpJ-Fas^lpr mice at 3 and 5 months

renal/urinary system

glomerulonephritis ( J:132514 )

• less severe than MRL/MpJ-Fas^lpr mice at 3 and 5 months

vision/eye

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 16% of infiltrate

• B cells are somewhat less abundant in infiltrates (18%) than in double mutants

endocrine/exocrine glands

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 16% of infiltrate

• B cells are somewhat less abundant in infiltrates (18%) than in double mutants

Allelic Composition	Il4^tm1Cgn/Il4^tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background	NOD.Cg-Il4^tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Cgn mutation (4 available); any Il4 mutation (42 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

insulitis ( J:85924 )

• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice

immune system

insulitis ( J:85924 )

• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice

decreased susceptibility to autoimmune diabetes ( J:85924 )

• Il4-deficient transgenic NOD mice do not show early or frequent diabetes compared to control transgenic NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:85924

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