About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Relnrl
reeler
MGI:1856398
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Relnrl/Relnrl B6.Cg-Relnrl MGI:3640191
hm2
Relnrl/Relnrl C3.Cg-Relnrl MGI:3640190
hm3
Relnrl/Relnrl involves: 129S4/SvJaeSor * C57BL/6J MGI:2654921
hm4
Relnrl/Relnrl involves: BALB/c MGI:4835177
hm5
Relnrl/Relnrl involves: C3HeB/FeJ * C57BL/6J MGI:3514040
hm6
Relnrl/Relnrl Not Specified MGI:2684661
ht7
Relnrl/Reln+ B6C3Fe a/a-Relnrl/J MGI:5661067
ht8
Relnrl/Reln+ B6.Cg-Relnrl MGI:5689835
ht9
Relnrl/Reln+ involves: BALB/c MGI:3720601
cn10
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365610
cn11
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365611
cn12
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365612
cx13
Dab1tm3.1Cpr/Dab1tm3.1Cpr
Relnrl/Reln+
involves: 129S4/SvJaeSor * C57BL/6J MGI:3810296
cx14
Dab1tm1Cpr/Dab1tm4Cpr
Relnrl/Reln+
involves: 129/Sv * C3HeB/Fe * C57BL/6 MGI:3050790
cx15
Relnrl/Relnrl
Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
involves: BALB/c * C57BL/6 * C57BL/6J MGI:4889081


Genotype
MGI:3640191
hm1
Allelic
Composition
Relnrl/Relnrl
Genetic
Background
B6.Cg-Relnrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: all die by 30 days of age, earlier than on a C3H/HeJ background

behavior/neurological
• Background Sensitivity: if turned on the side, mutants on a C57BL/6J background kick all legs futilely in unison and may not be able to right themselves without assistance, a phenotype not seen on the C3H/HeJ background
• Background Sensitivity: mice show rapid unsustained low amplitude tremor of the body when walking starting at P13 that is not readily observed on a C3H/HeJ background
• Background Sensitivity: mice show ataxic gait beginning at P13 that is more severe than on a C3H/HeJ background
• hind legs tend to splay and mice frequently fall on their sides
• Background Sensitivity: general level of activity begins to decrease during the third week of life unlike on a C3H/HeJ background in which activity is normal

growth/size/body
• Background Sensitivity: mice attain maximum weight by the end of the second week of life, then growth ceases during the third week and mutants remain smaller thereafter
• Background Sensitivity: growth retardation is more severe than on a C3H/HeJ background

reproductive system
• Background Sensitivity: mutants with a C57BL/6J background do not live long enough to breed while those with a C3H/HeJ background may be fertile

nervous system
• the entorhinal cortex exhibits an outer zone of tangentially oriented polymorphic cells in the superficial plane normally given to an external plexiform layer
• a wide inner zone of larger cells in the entorhinal cortex is cytologically similar to the outer large cell layers of the normal
• CA1 has two separate cellular laminae
• CA2 is subluxed away from its junction with CA1
• many granule cells of the dentate gyrus are scattered through the hilus and are intermixed with large cells of CA4
• the piriform cortex is composed of an outer polymorphic and inner large cell zone, resembling the deep polymorphic and overlying pyramidal zones of wild-type
• immediately subjacent to the lateral olfactory tract, the outer polymorphic zone is attenuated
• fiber bundles course from the olfactory crus in aberrant superficial relation to the lateral olfactory tract and join the main mass of the anterior commissure at a more caudal level




Genotype
MGI:3640190
hm2
Allelic
Composition
Relnrl/Relnrl
Genetic
Background
C3.Cg-Relnrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: 80% die by 40 days of age, the rest survive and are in normal health, indicating increased vitality than on a C57BL/6J background

behavior/neurological
N
• Background Sensitivity: mutants on a C57BL/6J background crossed to C3H/HeJ to the N7 generation only show mild behavioral/neurological disabilities compared to mutants on a C57BL/6J background, and are able to right themselves and remain active
• Background Sensitivity: at around 4 weeks of age, develop a more moderate ataxia during ambulation than on a C57BL/6J background

growth/size/body
• Background Sensitivity: growth retardation is much less severe than on a C57BL/6J background
• Background Sensitivity: exhibit normal weight gain during the first 2 weeks of life, then growth decreases in the third week but weight gain resumes after weaning, although at a slower rate so that by 60 days, they are still growing but weight is less than 70% of wild-type

digestive/alimentary system
• more than half of the mutants lost during the 20- to 30-day interval die as a consequence of diarrhea

nervous system
• different classes of neurons take their orgin from the ependymal layer at the normal time but migrate abnormally and come to rest in abnormal relations to each other
• migratory ascent along the radial glial fibers (RGF) proceeds normally as the cell crosses the IZ but is blocked upon encounter with postmigratory neurons within the cortex
• the entorhinal cortex exhibits an outer zone of tangentially oriented polymorphic cells in the superficial plane normally given to an external plexiform layer
• a wide inner zone of larger cells in the entorhinal cortex is cytologically similar to the outer large cell layers of the normal
• CA1 has two separate cellular laminae
• CA2 is subluxed away from its junction with CA1
• many granule cells of the dentate gyrus are scattered through the hilus and are intermixed with large cells of CA4
• the ascending glial fiber gives rise to 3 or less terminal branches (compared to 3-5 or more in wild-type) within the superplate (SP) rather than the pleriform zone (PZ)
• at the lower margin of the cortex, cells are frequently found bunched close one upon the other with substantial overlap of radially adjacent cells and the leading processes of these cells are abnormally short and blunt
• extent of contact between the somatic surfaces of postmigratory neurons and the surfaces of the radial glial fibers is substantially greater than in wild-type indicating abnormal adhesions between the postmigratory cells and the radial glial fibers
• the piriform cortex is composed of an outer polymorphic and inner large cell zone, resembling the deep polymorphic and overlying pyramidal zones of wild-type
• immediately subjacent to the lateral olfactory tract, the outer polymorphic zone is attenuated
• fiber bundles course from the olfactory crus in aberrant superficial relation to the lateral olfactory tract and join the main mass of the anterior commissure at a more caudal level

cellular
• different classes of neurons take their orgin from the ependymal layer at the normal time but migrate abnormally and come to rest in abnormal relations to each other
• migratory ascent along the radial glial fibers (RGF) proceeds normally as the cell crosses the IZ but is blocked upon encounter with postmigratory neurons within the cortex




Genotype
MGI:2654921
hm3
Allelic
Composition
Relnrl/Relnrl
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the neocortical marginal zone is crowded with polymorphic cells unlike in wild-type mice
• the dentate gyrus is disrupted
• the pyramidal cells are scattered over a broad region unlike in wild-type mice




Genotype
MGI:4835177
hm4
Allelic
Composition
Relnrl/Relnrl
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• vestibular stimulation improves the ability of females to mate with experienced males
• vestibular stimulation improves the ability of males to mate with experienced females




Genotype
MGI:3514040
hm5
Allelic
Composition
Relnrl/Relnrl
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• abnormal arrangement of neurons is seen in brain structures
• autoradiographic studies of development of the cerebral cortex have shown that the different classes of neurons originate from the ependymal layer at the normal time but migrate abnormally in relation to each other
• typical organization and lamination of the cerebellar cortex, the cerebral cortex, and the hippocampus are affected

cellular
• abnormal arrangement of neurons is seen in brain structures




Genotype
MGI:2684661
hm6
Allelic
Composition
Relnrl/Relnrl
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• many die at around 3 weeks of age, although delaying weaning and providing moist food prolongs life

growth/size/body
• often smaller at around 15 days of age

behavior/neurological
• a slight tremor of the foot is usually seen when the mutants fall and a more generalized tremor is sometimes seen when the mutant is excited and active
• unable to keep hindquaters upright and when walking or running, frequently fall over on their sides
• when standing still, hindquaters sway slowly from side to side and when walking, swaying is accentuated and the mutant falls over on its side, however righting is easily achieved
• exhibit some improvement with age as some adults are able to run without falling over, however legs are kept further apart
• reduction in activity is identifiable at 15 days of age

reproductive system
• majority of females are sterile

integument
• fur of adults exhibits an unkempt appearance




Genotype
MGI:5661067
ht7
Allelic
Composition
Relnrl/Reln+
Genetic
Background
B6C3Fe a/a-Relnrl/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show an elevation of dopamine D3 receptor expression in the ventral striatum, particularly in the nucleus accumbens and tuberculum olfactorium
• mice exhibit a reduction in the number of tyrosine hydroxylase-immunoreactive cell bodies in the ventral tegmental area, but not in the medial substantia nigra, pars compacta, indicating dopamine cell loss in the ventral striatum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:107996




Genotype
MGI:5689835
ht8
Allelic
Composition
Relnrl/Reln+
Genetic
Background
B6.Cg-Relnrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• chronic administration of corticosterone to induce high stress hormone levels results in disrupted short-term spatial memory in both males and females as indicated by mice showing no preference for the novel arm of the Y-maze as seen in controls
• however, unstressed mutants show normal spatial memory on the Y-maze
• untreated and corticosterone treated (stressed) males spend less time sniffing a novel mouse during phase 2 of the social recognition test when mice can choose between a novel and a familiar mouse, indicating impaired social recognition memory

nervous system
• corticosterone treated males do not exhibit disrupted prepulse inhibition as is seen in wild-type corticosterone treated males, indicating that males are resilient to the effects of stress on prepulse inhibition

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:223944




Genotype
MGI:3720601
ht9
Allelic
Composition
Relnrl/Reln+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• cerebellum is normally foliated and qualitatively indistinguishable from that of wild-type controls
• males, but not females, have a 16% reduction in the number of Purkinje cells at 3 months of age and a 24% reduction at 16 months of age with the loss occurring throughout the mediolateral extent of the cerebellum
• males, but not females, have reduction in overall cross-sectional area of the cerebella at 3 and 16 months of age




Genotype
MGI:4365610
cn10
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (967 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 72% at P0




Genotype
MGI:4365611
cn11
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (967 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 35% at P0




Genotype
MGI:4365612
cn12
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (967 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (46 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0
• nearly all CRc in the hippocampal formation are ablated




Genotype
MGI:3810296
cx13
Allelic
Composition
Dab1tm3.1Cpr/Dab1tm3.1Cpr
Relnrl/Reln+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm3.1Cpr mutation (0 available); any Dab1 mutation (77 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• the hippocampus and neocortex are normal




Genotype
MGI:3050790
cx14
Allelic
Composition
Dab1tm1Cpr/Dab1tm4Cpr
Relnrl/Reln+
Genetic
Background
involves: 129/Sv * C3HeB/Fe * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation (1 available); any Dab1 mutation (77 available)
Dab1tm4Cpr mutation (0 available); any Dab1 mutation (77 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the marginal zone of the cortex is reduced, similar to compound heterozygous mice wild-type for Reln
• the hippocampus is subtly disorganized in the CA2/3 region compared to mice heterozygous for Dab1tm1Cpr and Relnrl




Genotype
MGI:4889081
cx15
Allelic
Composition
Relnrl/Relnrl
Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation (3 available); any Reln mutation (209 available)
Tg(Mbp-MAPT/lacZ)#aCaw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice

cellular
• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/02/2024
MGI 6.13
The Jackson Laboratory